LYVE1

Extracellular link domain containing 1, also known as XLKD1, is a human gene.cite web | title = Entrez Gene: XLKD1 extracellular link domain containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10894| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis.cite web | title = Entrez Gene: XLKD1 extracellular link domain containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10894| accessdate = ] LYVE-1 is a cell surface receptor on lymphatic endothelial cells that can be used as a lymphatic endothelial cell marker, and sort these cells for experimental purposes. So far the physiological role for this receptor is till the subject of debate, but evolutionary conservation suggests an important role.

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Jackson DG |title=The lymphatics revisited: new perspectives from the hyaluronan receptor LYVE-1. |journal=Trends Cardiovasc. Med. |volume=13 |issue= 1 |pages= 1–7 |year= 2003 |pmid= 12554094 |doi=
*cite journal | author=Banerji S, Ni J, Wang SX, "et al." |title=LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan. |journal=J. Cell Biol. |volume=144 |issue= 4 |pages= 789–801 |year= 1999 |pmid= 10037799 |doi=
*cite journal | author=Cunnick GH, Jiang WG, Gomez KF, Mansel RE |title=Lymphangiogenesis quantification using quantitative PCR and breast cancer as a model. |journal=Biochem. Biophys. Res. Commun. |volume=288 |issue= 4 |pages= 1043–6 |year= 2001 |pmid= 11689016 |doi= 10.1006/bbrc.2001.5869
*cite journal | author=Mouta Carreira C, Nasser SM, di Tomaso E, "et al." |title=LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis. |journal=Cancer Res. |volume=61 |issue= 22 |pages= 8079–84 |year= 2001 |pmid= 11719431 |doi=
*cite journal | author=Cursiefen C, Schlötzer-Schrehardt U, Küchle M, "et al." |title=Lymphatic vessels in vascularized human corneas: immunohistochemical investigation using LYVE-1 and podoplanin. |journal=Invest. Ophthalmol. Vis. Sci. |volume=43 |issue= 7 |pages= 2127–35 |year= 2002 |pmid= 12091407 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Huang SS, Tang FM, Huang YH, "et al." |title=Cloning, expression, characterization, and role in autocrine cell growth of cell surface retention sequence binding protein-1. |journal=J. Biol. Chem. |volume=278 |issue= 44 |pages= 43855–69 |year= 2003 |pmid= 12912978 |doi= 10.1074/jbc.M306411200
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Otsuki T, Ota T, Nishikawa T, "et al." |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117
*cite journal | author=Liu T, Qian WJ, Gritsenko MA, "et al." |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Nguyen VA, Kutzner H, Fürhapter C, "et al." |title=Infantile hemangioma is a proliferation of LYVE-1-negative blood endothelial cells without lymphatic competence. |journal=Mod. Pathol. |volume=19 |issue= 2 |pages= 291–8 |year= 2006 |pmid= 16424896 |doi= 10.1038/modpathol.3800537
*cite journal | author=Gu B, Alexander JS, Gu Y, "et al." |title=Expression of lymphatic vascular endothelial hyaluronan receptor-1 (LYVE-1) in the human placenta. |journal=Lymphatic research and biology |volume=4 |issue= 1 |pages= 11–7 |year= 2007 |pmid= 16569201 |doi= 10.1089/lrb.2006.4.11
*cite journal | author=Llovet JM, Chen Y, Wurmbach E, "et al." |title=A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis. |journal=Gastroenterology |volume=131 |issue= 6 |pages= 1758–67 |year= 2007 |pmid= 17087938 |doi= 10.1053/j.gastro.2006.09.014

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