Pancreatic hormone

Pancreatic hormone

Pfam_box
Symbol = Hormone_3
Name = Pancreatic hormone peptide


width =
caption =
Pfam= PF00159
InterPro= IPR001955
SMART=
PROSITE = PDOC00238
SCOP = 1ppt
TCDB =
OPM family=
OPM protein= 1icy
PDB=PDB3|1k8vA:1-39 PDB3|1ruuA:1-36 PDB3|1ru5A:1-36PDB3|1qbfA:1-36 PDB3|1ron :29-64 PDB3|1qfaA:52-64PDB3|1r9nF:29-38 PDB3|1icyA:10-45 PDB3|1f8pA:10-45PDB3|1fvnA:10-45 PDB3|1ljvA:30-65 PDB3|1v1dA:30-60PDB3|1bba :30-65 PDB3|2bf9A:1-35 PDB3|1ppt :1-36

Pancreatic hormones (PP)cite journal |author=Humbel RE, Blundell TL |title=Hormone families:pancreatic hormones and homologous growth factors |journal=Nature |volume=287 |issue=5785 |pages=781–787 |year=1980 |pmid=6107857 |doi=10.1038/287781a0] are peptides synthesized in pancreatic islets of Langherhans, which acts as a regulator of pancreatic and gastrointestinal functions.

The hormone is produced as a larger propeptide, which is enzymatically cleaved to yield the mature active peptide: this is 36 amino acids in lengthcite journal |author=Martin J, Allen J, Novotny J, Heinrich G |title=Molecular structure of mammalian neuropeptide Y: analysis by molecular cloning and computer-aided comparison with crystal structure of avian homologue |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue=8 |pages=2532–2536 |year=1987 |pmid=3031687 |doi=10.1073/pnas.84.8.2532] and has an amidated C terminuscite journal |author=Mutt V, Sillard R, Agerberth B, Jornvall H |title=Sheep neuropeptide Y. A third structural type of a highly conserved peptide |journal=FEBS Lett. |volume=258 |issue=2 |pages=263–265 |year=1989 |pmid=2599092 |doi=10.1016/0014-5793(89)81669-2] . The hormone has a globular structure, residues 2-8 forming a left-handed poly-proline-II-like helix, residues 9-13 a beta turn, and 14-32 an alpha-helix,held close to the first helix by hydrophobic interactions. Unlike glucagon, another peptide hormone, the structure of pancreatic peptide is preserved in aqueous solutioncite journal |author=Conlon JM, Thim L, Bjenning C, Moon TW, Youson JH |title=Neuropeptide Y-related peptides from the pancreas of a teleostean (eel), holostean (bowfin) and elasmobranch (skate) fish |journal=Peptides |volume=12 |issue=2 |pages=221–226 |year=1991 |pmid=2067973 |doi=10.1016/0196-9781(91)90003-8] . Both N and C termini are required for activity: receptor binding and activation functions may reside in the N and C termini respectivelycite journal |author=Martin J, Allen J, Novotny J, Heinrich G |title=Molecular structure of mammalian neuropeptide Y: analysis by molecular cloning and computer-aided comparison with crystal structure of avian homologue |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue=8 |pages=2532–2536 |year=1987 |pmid=3031687 |doi=10.1073/pnas.84.8.2532] .

ubfamilies

*Pancreatic hormone subtype InterPro|IPR015480
*Peptide YY InterPro|IPR015481

Human proteins containing this domain

NPY; PPY; PYY;

References


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