FGF19

FGF19

Fibroblast growth factor 19, also known as FGF19, is a human gene.cite web | title = Entrez Gene: FGF19 fibroblast growth factor 19| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9965| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development.cite web | title = Entrez Gene: FGF19 fibroblast growth factor 19| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9965| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nishimura T, Utsunomiya Y, Hoshikawa M, "et al." |title=Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain. |journal=Biochim. Biophys. Acta |volume=1444 |issue= 1 |pages= 148–51 |year= 1999 |pmid= 9931477 |doi=
*cite journal | author=Xie MH, Holcomb I, Deuel B, "et al." |title=FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4. |journal=Cytokine |volume=11 |issue= 10 |pages= 729–35 |year= 1999 |pmid= 10525310 |doi= 10.1006/cyto.1999.0485
*cite journal | author=Ladher RK, Anakwe KU, Gurney AL, "et al." |title=Identification of synergistic signals initiating inner ear development. |journal=Science |volume=290 |issue= 5498 |pages= 1965–7 |year= 2000 |pmid= 11110663 |doi=
*cite journal | author=Tomlinson E, Fu L, John L, "et al." |title=Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity. |journal=Endocrinology |volume=143 |issue= 5 |pages= 1741–7 |year= 2002 |pmid= 11956156 |doi=
*cite journal | author=Nicholes K, Guillet S, Tomlinson E, "et al." |title=A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice. |journal=Am. J. Pathol. |volume=160 |issue= 6 |pages= 2295–307 |year= 2002 |pmid= 12057932 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Katoh M, Katoh M |title=Evolutionary conservation of CCND1-ORAOV1-FGF19-FGF4 locus from zebrafish to human. |journal=Int. J. Mol. Med. |volume=12 |issue= 1 |pages= 45–50 |year= 2004 |pmid= 12792807 |doi=
*cite journal | author=Holt JA, Luo G, Billin AN, "et al." |title=Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. |journal=Genes Dev. |volume=17 |issue= 13 |pages= 1581–91 |year= 2003 |pmid= 12815072 |doi= 10.1101/gad.1083503
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Harmer NJ, Pellegrini L, Chirgadze D, "et al." |title=The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity. |journal=Biochemistry |volume=43 |issue= 3 |pages= 629–40 |year= 2004 |pmid= 14730967 |doi= 10.1021/bi035320k
*cite journal | author=Fu L, John LM, Adams SH, "et al." |title=Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes. |journal=Endocrinology |volume=145 |issue= 6 |pages= 2594–603 |year= 2004 |pmid= 14976145 |doi= 10.1210/en.2003-1671
*cite journal | author=Popovici C, Conchonaud F, Birnbaum D, Roubin R |title=Functional phylogeny relates LET-756 to fibroblast growth factor 9. |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 40146–52 |year= 2004 |pmid= 15199049 |doi= 10.1074/jbc.M405795200
*cite journal | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Tamimi Y, Skarie JM, Footz T, "et al." |title=FGF19 is a target for FOXC1 regulation in ciliary body-derived cells. |journal=Hum. Mol. Genet. |volume=15 |issue= 21 |pages= 3229–40 |year= 2006 |pmid= 17000708 |doi= 10.1093/hmg/ddl400
*cite journal | author=Goetz R, Beenken A, Ibrahimi OA, "et al." |title=Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members. |journal=Mol. Cell. Biol. |volume=27 |issue= 9 |pages= 3417–28 |year= 2007 |pmid= 17339340 |doi= 10.1128/MCB.02249-06
*cite journal | author=Wu X, Ge H, Gupte J, "et al." |title=Co-receptor requirements for fibroblast growth factor-19 signaling. |journal=J. Biol. Chem. |volume=282 |issue= 40 |pages= 29069–72 |year= 2007 |pmid= 17711860 |doi= 10.1074/jbc.C700130200

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