SYMPK

Symplekin, also known as SYMPK, is a human gene.cite web | title = Entrez Gene: SYMPK symplekin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8189| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types.cite web | title = Entrez Gene: SYMPK symplekin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8189| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Keon BH, Schäfer S, Kuhn C, "et al." |title=Symplekin, a novel type of tight junction plaque protein. |journal=J. Cell Biol. |volume=134 |issue= 4 |pages= 1003–18 |year= 1996 |pmid= 8769423 |doi=
*cite journal | author=Ueki K, Ramaswamy S, Billings SJ, "et al." |title=Chromosomal localization to 19q13.3, partial genomic structure and 5' cDNA sequence of the human symplekin gene. |journal=Somat. Cell Mol. Genet. |volume=23 |issue= 3 |pages= 229–31 |year= 1997 |pmid= 9330635 |doi=
*cite journal | author=Alwazzan M, Hamshere MG, Lennon GG, Brook JD |title=Six transcripts map within 200 kilobases of the myotonic dystrophy expanded repeat. |journal=Mamm. Genome |volume=9 |issue= 6 |pages= 485–7 |year= 1998 |pmid= 9585442 |doi=
*cite journal | author=Faber PW, Barnes GT, Srinidhi J, "et al." |title=Huntingtin interacts with a family of WW domain proteins. |journal=Hum. Mol. Genet. |volume=7 |issue= 9 |pages= 1463–74 |year= 1998 |pmid= 9700202 |doi=
*cite journal | author=Paffenholz R, Kuhn C, Grund C, "et al." |title=The arm-repeat protein NPRAP (neurojungin) is a constituent of the plaques of the outer limiting zone in the retina, defining a novel type of adhering junction. |journal=Exp. Cell Res. |volume=250 |issue= 2 |pages= 452–64 |year= 1999 |pmid= 10413599 |doi= 10.1006/excr.1999.4534
*cite journal | author=Takagaki Y, Manley JL |title=Complex protein interactions within the human polyadenylation machinery identify a novel component. |journal=Mol. Cell. Biol. |volume=20 |issue= 5 |pages= 1515–25 |year= 2000 |pmid= 10669729 |doi=
*cite journal | author=Venter JC, Adams MD, Myers EW, "et al." |title=The sequence of the human genome. |journal=Science |volume=291 |issue= 5507 |pages= 1304–51 |year= 2001 |pmid= 11181995 |doi= 10.1126/science.1058040
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Langbein L, Pape UF, Grund C, "et al." |title=Tight junction-related structures in the absence of a lumen: occludin, claudins and tight junction plaque proteins in densely packed cell formations of stratified epithelia and squamous cell carcinomas. |journal=Eur. J. Cell Biol. |volume=82 |issue= 8 |pages= 385–400 |year= 2004 |pmid= 14533737 |doi=
*cite journal | author=Xing H, Mayhew CN, Cullen KE, "et al." |title=HSF1 modulation of Hsp70 mRNA polyadenylation via interaction with symplekin. |journal=J. Biol. Chem. |volume=279 |issue= 11 |pages= 10551–5 |year= 2004 |pmid= 14707147 |doi= 10.1074/jbc.M311719200
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Barnard DC, Ryan K, Manley JL, Richter JD |title=Symplekin and xGLD-2 are required for CPEB-mediated cytoplasmic polyadenylation. |journal=Cell |volume=119 |issue= 5 |pages= 641–51 |year= 2005 |pmid= 15550246 |doi= 10.1016/j.cell.2004.10.029
*cite journal | author=Kolev NG, Steitz JA |title=Symplekin and multiple other polyadenylation factors participate in 3'-end maturation of histone mRNAs. |journal=Genes Dev. |volume=19 |issue= 21 |pages= 2583–92 |year= 2006 |pmid= 16230528 |doi= 10.1101/gad.1371105
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Kavanagh E, Buchert M, Tsapara A, "et al." |title=Functional interaction between the ZO-1-interacting transcription factor ZONAB/DbpA and the RNA processing factor symplekin. |journal=J. Cell. Sci. |volume=119 |issue= Pt 24 |pages= 5098–105 |year= 2007 |pmid= 17158914 |doi= 10.1242/jcs.03297

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