PRRX1

Paired related homeobox 1, also known as PRRX1, is a human gene.cite web | title = Entrez Gene: PRRX1 paired related homeobox 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5396| accessdate = ]

PBB_Summary
section_title =
summary_text = The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns.cite web | title = Entrez Gene: PRRX1 paired related homeobox 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5396| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Grueneberg DA, Natesan S, Alexandre C, Gilman MZ |title=Human and Drosophila homeodomain proteins that enhance the DNA-binding activity of serum response factor. |journal=Science |volume=257 |issue= 5073 |pages= 1089–95 |year= 1992 |pmid= 1509260 |doi=
*cite journal | author=Grueneberg DA, Simon KJ, Brennan K, Gilman M |title=Sequence-specific targeting of nuclear signal transduction pathways by homeodomain proteins. |journal=Mol. Cell. Biol. |volume=15 |issue= 6 |pages= 3318–26 |year= 1995 |pmid= 7760827 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Grueneberg DA, Henry RW, Brauer A, "et al." |title=A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I. |journal=Genes Dev. |volume=11 |issue= 19 |pages= 2482–93 |year= 1997 |pmid= 9334314 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Nakamura T, Yamazaki Y, Hatano Y, Miura I |title=NUP98 is fused to PMX1 homeobox gene in human acute myelogenous leukemia with chromosome translocation t(1;11)(q23;p15). |journal=Blood |volume=94 |issue= 2 |pages= 741–7 |year= 1999 |pmid= 10397741 |doi=
*cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, "et al." |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=
*cite journal | author=Kataoka K, Yoshitomo-Nakagawa K, Shioda S, Nishizawa M |title=A set of Hox proteins interact with the Maf oncoprotein to inhibit its DNA binding, transactivation, and transforming activities. |journal=J. Biol. Chem. |volume=276 |issue= 1 |pages= 819–26 |year= 2001 |pmid= 11036080 |doi= 10.1074/jbc.M007643200
*cite journal | author=Norris RA, Scott KK, Moore CS, "et al." |title=Human PRRX1 and PRRX2 genes: cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome. |journal=Mamm. Genome |volume=11 |issue= 11 |pages= 1000–5 |year= 2001 |pmid= 11063257 |doi=
*cite journal | author=Jones FS, Meech R, Edelman DB, "et al." |title=Prx1 controls vascular smooth muscle cell proliferation and tenascin-C expression and is upregulated with Prx2 in pulmonary vascular disease. |journal=Circ. Res. |volume=89 |issue= 2 |pages= 131–8 |year= 2001 |pmid= 11463719 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Izmailova E, Bertley FM, Huang Q, "et al." |title=HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. |journal=Nat. Med. |volume=9 |issue= 2 |pages= 191–7 |year= 2003 |pmid= 12539042 |doi= 10.1038/nm822
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Wissmüller S, Kosian T, Wolf M, "et al." |title=The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. |journal=Nucleic Acids Res. |volume=34 |issue= 6 |pages= 1735–44 |year= 2006 |pmid= 16582099 |doi= 10.1093/nar/gkl105
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727
*cite journal | author=Kim YJ, Ahn JY, Liang P, "et al." |title=Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: implication to tumor biology. |journal=Cancer Res. |volume=67 |issue= 2 |pages= 546–54 |year= 2007 |pmid= 17234762 |doi= 10.1158/0008-5472.CAN-06-2401

External links

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