SUFU

Suppressor of fused homolog (Drosophila), also known as SUFU, is a human gene.cite web | title = Entrez Gene: SUFU suppressor of fused homolog (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51684| accessdate = ]

PBB_Summary
section_title =
summary_text = SUFU encodes a component of the sonic hedgehog (SHH; MIM 600725)/patched (PTCH; MIM 601309) signaling pathway. Mutations in genes encoding components of this pathway are deleterious for normal development and are associated with cancer-predisposing syndromes (e.g., HPE3, MIM 142945; BCNS, MIM 109400; and GCPS, MIM 175700). [supplied by OMIM] cite web | title = Entrez Gene: SUFU suppressor of fused homolog (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51684| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kogerman P, Grimm T, Kogerman L, "et al." |title=Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1. |journal=Nat. Cell Biol. |volume=1 |issue= 5 |pages= 312–9 |year= 1999 |pmid= 10559945 |doi= 10.1038/13031
*cite journal | author=Stone DM, Murone M, Luoh S, "et al." |title=Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli. |journal=J. Cell. Sci. |volume=112 ( Pt 23) |issue= |pages= 4437–48 |year= 2000 |pmid= 10564661 |doi=
*cite journal | author=Murone M, Luoh SM, Stone D, "et al." |title=Gli regulation by the opposing activities of fused and suppressor of fused. |journal=Nat. Cell Biol. |volume=2 |issue= 5 |pages= 310–2 |year= 2000 |pmid= 10806483 |doi= 10.1038/35010610
*cite journal | author=Delattre M, Briand S, Paces-Fessy M, Blanchet-Tournier MF |title=The Suppressor of fused gene, involved in Hedgehog signal transduction in Drosophila, is conserved in mammals. |journal=Dev. Genes Evol. |volume=209 |issue= 5 |pages= 294–300 |year= 2001 |pmid= 11252182 |doi=
*cite journal | author=Cheng SY, Bishop JM |title=Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 8 |pages= 5442–7 |year= 2002 |pmid= 11960000 |doi= 10.1073/pnas.082096999
*cite journal | author=Taylor MD, Liu L, Raffel C, "et al." |title=Mutations in SUFU predispose to medulloblastoma. |journal=Nat. Genet. |volume=31 |issue= 3 |pages= 306–10 |year= 2002 |pmid= 12068298 |doi= 10.1038/ng916
*cite journal | author=Dunaeva M, Michelson P, Kogerman P, Toftgard R |title=Characterization of the physical interaction of Gli proteins with SUFU proteins. |journal=J. Biol. Chem. |volume=278 |issue= 7 |pages= 5116–22 |year= 2003 |pmid= 12426310 |doi= 10.1074/jbc.M209492200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Paces-Fessy M, Boucher D, Petit E, "et al." |title=The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins. |journal=Biochem. J. |volume=378 |issue= Pt 2 |pages= 353–62 |year= 2004 |pmid= 14611647 |doi= 10.1042/BJ20030786
*cite journal | author=Taylor MD, Zhang X, Liu L, "et al." |title=Failure of a medulloblastoma-derived mutant of SUFU to suppress WNT signaling. |journal=Oncogene |volume=23 |issue= 26 |pages= 4577–83 |year= 2004 |pmid= 15077159 |doi= 10.1038/sj.onc.1207605
*cite journal | author=Deloukas P, Earthrowl ME, Grafham DV, "et al." |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462
*cite journal | author=Merchant M, Vajdos FF, Ultsch M, "et al." |title=Suppressor of fused regulates Gli activity through a dual binding mechanism. |journal=Mol. Cell. Biol. |volume=24 |issue= 19 |pages= 8627–41 |year= 2004 |pmid= 15367681 |doi= 10.1128/MCB.24.19.8627-8641.2004
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Lyle R, Radhakrishna U, Blouin JL, "et al." |title=Split-hand/split-foot malformation 3 (SHFM3) at 10q24, development of rapid diagnostic methods and gene expression from the region. |journal=Am. J. Med. Genet. A |volume=140 |issue= 13 |pages= 1384–95 |year= 2006 |pmid= 16691619 |doi= 10.1002/ajmg.a.31247

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