ACSL3

Acyl-CoA synthetase long-chain family member 3, also known as ACSL3, is a human gene.cite web | title = Entrez Gene: ACSL3 acyl-CoA synthetase long-chain family member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2181| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene.cite web | title = Entrez Gene: ACSL3 acyl-CoA synthetase long-chain family member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2181| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Brueton LA, van Herwerden L, Chotai KA, Winter RM |title=The mapping of a gene for craniosynostosis: evidence for linkage of the Saethre-Chotzen syndrome to distal chromosome 7p. |journal=J. Med. Genet. |volume=29 |issue= 10 |pages= 681–5 |year= 1992 |pmid= 1433226 |doi=
*cite journal | author=Bakken AM, Farstad M, Holmsen H |title=Identity between palmitoyl-CoA synthetase and arachidonoyl-CoA synthetase in human platelet? |journal=Biochem. J. |volume=274 ( Pt 1) |issue= |pages= 145–52 |year= 1991 |pmid= 1848073 |doi=
*cite journal | author=Bronfman M, Inestrosa NC, Nervi FO, Leighton F |title=Acyl-CoA synthetase and the peroxisomal enzymes of beta-oxidation in human liver. Quantitative analysis of their subcellular localization. |journal=Biochem. J. |volume=224 |issue= 3 |pages= 709–20 |year= 1985 |pmid= 6240978 |doi=
*cite journal | author=Rose CS, King AA, Summers D, "et al." |title=Localization of the genetic locus for Saethre-Chotzen syndrome to a 6 cM region of chromosome 7 using four cases with apparently balanced translocations at 7p21.2. |journal=Hum. Mol. Genet. |volume=3 |issue= 8 |pages= 1405–8 |year= 1995 |pmid= 7987323 |doi=
*cite journal | author=Fujino T, Kang MJ, Suzuki H, "et al." |title=Molecular characterization and expression of rat acyl-CoA synthetase 3. |journal=J. Biol. Chem. |volume=271 |issue= 28 |pages= 16748–52 |year= 1996 |pmid= 8663269 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Minekura H, Fujino T, Kang MJ, "et al." |title=Human acyl-coenzyme A synthetase 3 cDNA and localization of its gene (ACS3) to chromosome band 2q34-q35. |journal=Genomics |volume=42 |issue= 1 |pages= 180–1 |year= 1997 |pmid= 9177793 |doi= 10.1006/geno.1997.4710
*cite journal | author=Minekura H, Kang MJ, Inagaki Y, "et al." |title=Genomic organization and transcription units of the human acyl-CoA synthetase 3 gene. |journal=Gene |volume=278 |issue= 1-2 |pages= 185–92 |year= 2002 |pmid= 11707336 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Mashek DG, Bornfeldt KE, Coleman RA, "et al." |title=Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family. |journal=J. Lipid Res. |volume=45 |issue= 10 |pages= 1958–61 |year= 2005 |pmid= 15292367 |doi= 10.1194/jlr.E400002-JLR200
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Qiao S, Tuohimaa P |title=Vitamin D3 inhibits fatty acid synthase expression by stimulating the expression of long-chain fatty-acid-CoA ligase 3 in prostate cancer cells. |journal=FEBS Lett. |volume=577 |issue= 3 |pages= 451–4 |year= 2005 |pmid= 15556626 |doi= 10.1016/j.febslet.2004.10.044
*cite journal | author=Rohozinski J, Lamb DJ, Bishop CE |title=UTP14c is a recently acquired retrogene associated with spermatogenesis and fertility in man. |journal=Biol. Reprod. |volume=74 |issue= 4 |pages= 644–51 |year= 2006 |pmid= 16354793 |doi= 10.1095/biolreprod.105.046698
*cite journal | author=Tu LC, Yan X, Hood L, Lin B |title=Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells. |journal=Mol. Cell Proteomics |volume=6 |issue= 4 |pages= 575–88 |year= 2007 |pmid= 17220478 |doi= 10.1074/mcp.M600249-MCP200
*cite journal | author=Zhou Y, Abidi P, Kim A, "et al." |title=Transcriptional activation of hepatic ACSL3 and ACSL5 by oncostatin m reduces hypertriglyceridemia through enhanced beta-oxidation. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=27 |issue= 10 |pages= 2198–205 |year= 2007 |pmid= 17761945 |doi= 10.1161/ATVBAHA.107.148429

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