VPS26A

Vacuolar protein sorting 26 homolog A (S. pombe), also known as VPS26A, is a human gene.cite web | title = Entrez Gene: VPS26A vacuolar protein sorting 26 homolog A (S. pombe)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9559| accessdate = ]

This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms.cite web | title = Entrez Gene: VPS26A vacuolar protein sorting 26 homolog A (S. pombe)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9559| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lee JJ, Radice G, Perkins CP, Costantini F |title=Identification and characterization of a novel, evolutionarily conserved gene disrupted by the murine H beta 58 embryonic lethal transgene insertion. |journal=Development |volume=115 |issue= 1 |pages= 277–88 |year= 1992 |pmid= 1638986 |doi=
*cite journal | author=Mao M, Fu G, Wu JS, "et al." |title=Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 14 |pages= 8175–80 |year= 1998 |pmid= 9653160 |doi=
*cite journal | author=Zhang QH, Ye M, Wu XY, "et al." |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=
*cite journal | author=Haft CR, de la Luz Sierra M, Bafford R, "et al." |title=Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. |journal=Mol. Biol. Cell |volume=11 |issue= 12 |pages= 4105–16 |year= 2001 |pmid= 11102511 |doi=
*cite journal | author=Reddy JV, Seaman MN |title=Vps26p, a component of retromer, directs the interactions of Vps35p in endosome-to-Golgi retrieval. |journal=Mol. Biol. Cell |volume=12 |issue= 10 |pages= 3242–56 |year= 2002 |pmid= 11598206 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Deloukas P, Earthrowl ME, Grafham DV, "et al." |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462
*cite journal | author=Vergés M, Luton F, Gruber C, "et al." |title=The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor. |journal=Nat. Cell Biol. |volume=6 |issue= 8 |pages= 763–9 |year= 2004 |pmid= 15247922 |doi= 10.1038/ncb1153
*cite journal | author=Mingot JM, Bohnsack MT, Jäkle U, Görlich D |title=Exportin 7 defines a novel general nuclear export pathway. |journal=EMBO J. |volume=23 |issue= 16 |pages= 3227–36 |year= 2005 |pmid= 15282546 |doi= 10.1038/sj.emboj.7600338
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kerr MC, Bennetts JS, Simpson F, "et al." |title=A novel mammalian retromer component, Vps26B. |journal=Traffic |volume=6 |issue= 11 |pages= 991–1001 |year= 2006 |pmid= 16190980 |doi= 10.1111/j.1600-0854.2005.00328.x
*cite journal | author=Small SA, Kent K, Pierce A, "et al." |title=Model-guided microarray implicates the retromer complex in Alzheimer's disease. |journal=Ann. Neurol. |volume=58 |issue= 6 |pages= 909–19 |year= 2006 |pmid= 16315276 |doi= 10.1002/ana.20667
*cite journal | author=Gullapalli A, Wolfe BL, Griffin CT, "et al." |title=An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins. |journal=Mol. Biol. Cell |volume=17 |issue= 3 |pages= 1228–38 |year= 2006 |pmid= 16407403 |doi= 10.1091/mbc.E05-09-0899
*cite journal | author=Shi H, Rojas R, Bonifacino JS, Hurley JH |title=The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain. |journal=Nat. Struct. Mol. Biol. |volume=13 |issue= 6 |pages= 540–8 |year= 2006 |pmid= 16732284 |doi= 10.1038/nsmb1103
*cite journal | author=Riemenschneider M, Schoepfer-Wendels A, Friedrich P, "et al." |title=No association of vacuolar protein sorting 26 polymorphisms with Alzheimer's disease. |journal=Neurobiol. Aging |volume=28 |issue= 6 |pages= 883–4 |year= 2007 |pmid= 16784798 |doi= 10.1016/j.neurobiolaging.2006.05.009
*cite journal | author=Rojas R, Kametaka S, Haft CR, Bonifacino JS |title=Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors. |journal=Mol. Cell. Biol. |volume=27 |issue= 3 |pages= 1112–24 |year= 2007 |pmid= 17101778 |doi= 10.1128/MCB.00156-06

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