CRADD

CASP2 and RIPK1 domain containing adaptor with death domain, also known as CRADD, is a human gene.cite web | title = Entrez Gene: CRADD CASP2 and RIPK1 domain containing adaptor with death domain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8738| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.cite web | title = Entrez Gene: CRADD CASP2 and RIPK1 domain containing adaptor with death domain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8738| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lennon G, Auffray C, Polymeropoulos M, Soares MB |title=The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. |journal=Genomics |volume=33 |issue= 1 |pages= 151–2 |year= 1996 |pmid= 8617505 |doi= 10.1006/geno.1996.0177
*cite journal | author=Hillier LD, Lennon G, Becker M, "et al." |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=
*cite journal | author=Duan H, Dixit VM |title=RAIDD is a new 'death' adaptor molecule. |journal=Nature |volume=385 |issue= 6611 |pages= 86–9 |year= 1997 |pmid= 8985253 |doi= 10.1038/385086a0
*cite journal | author=Ahmad M, Srinivasula SM, Wang L, "et al." |title=CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP. |journal=Cancer Res. |volume=57 |issue= 4 |pages= 615–9 |year= 1997 |pmid= 9044836 |doi=
*cite journal | author=Chou JJ, Matsuo H, Duan H, Wagner G |title=Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment. |journal=Cell |volume=94 |issue= 2 |pages= 171–80 |year= 1998 |pmid= 9695946 |doi=
*cite journal | author=Horvat S, Medrano JF |title=A 500-kb YAC and BAC contig encompassing the high-growth deletion in mouse chromosome 10 and identification of the murine Raidd/Cradd gene in the candidate region. |journal=Genomics |volume=54 |issue= 1 |pages= 159–64 |year= 1999 |pmid= 9806843 |doi= 10.1006/geno.1998.5540
*cite journal | author=Shearwin-Whyatt LM, Harvey NL, Kumar S |title=Subcellular localization and CARD-dependent oligomerization of the death adaptor RAIDD. |journal=Cell Death Differ. |volume=7 |issue= 2 |pages= 155–65 |year= 2000 |pmid= 10713730 |doi= 10.1038/sj.cdd.4400632
*cite journal | author=Chaudhary PM, Eby MT, Jasmin A, "et al." |title=Activation of the NF-kappaB pathway by caspase 8 and its homologs. |journal=Oncogene |volume=19 |issue= 39 |pages= 4451–60 |year= 2000 |pmid= 11002417 |doi= 10.1038/sj.onc.1203812
*cite journal | author=Droin N, Beauchemin M, Solary E, Bertrand R |title=Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade. |journal=Cancer Res. |volume=60 |issue= 24 |pages= 7039–47 |year= 2001 |pmid= 11156409 |doi=
*cite journal | author=Guo Y, Srinivasula SM, Druilhe A, "et al." |title=Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13430–7 |year= 2002 |pmid= 11832478 |doi= 10.1074/jbc.M108029200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Tinel A, Tschopp J |title=The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. |journal=Science |volume=304 |issue= 5672 |pages= 843–6 |year= 2004 |pmid= 15073321 |doi= 10.1126/science.1095432
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Park HH, Wu H |title=Crystal structure of RAIDD death domain implicates potential mechanism of PIDDosome assembly. |journal=J. Mol. Biol. |volume=357 |issue= 2 |pages= 358–64 |year= 2006 |pmid= 16434054 |doi= 10.1016/j.jmb.2005.12.082
*cite journal | author=Vakifahmetoglu H, Olsson M, Orrenius S, Zhivotovsky B |title=Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage. |journal=Oncogene |volume=25 |issue= 41 |pages= 5683–92 |year= 2006 |pmid= 16652156 |doi= 10.1038/sj.onc.1209569
*cite journal | author=Park HH, Wu H |title=Crystallization and preliminary X-ray crystallographic studies of the oligomeric death-domain complex between PIDD and RAIDD. |journal=Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. |volume=63 |issue= Pt 3 |pages= 229–32 |year= 2007 |pmid= 17329820 |doi= 10.1107/S1744309107007889

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes