RECK

RECK

Reversion-inducing-cysteine-rich protein with kazal motifs, also known as RECK, is a human gene,cite web | title = Entrez Gene: RECK reversion-inducing-cysteine-rich protein with kazal motifs| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8434| accessdate = ] thought to be a metastasis suppressor.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis.cite web | title = Entrez Gene: RECK reversion-inducing-cysteine-rich protein with kazal motifs| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8434| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Takahashi C, Sheng Z, Horan TP, "et al." |title=Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 22 |pages= 13221–6 |year= 1998 |pmid= 9789069 |doi=
*cite journal | author=Gerstein M |title=Measurement of the effectiveness of transitive sequence comparison, through a third 'intermediate' sequence. |journal=Bioinformatics |volume=14 |issue= 8 |pages= 707–14 |year= 1998 |pmid= 9789096 |doi=
*cite journal | author=Oh J, Takahashi R, Kondo S, "et al." |title=The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. |journal=Cell |volume=107 |issue= 6 |pages= 789–800 |year= 2002 |pmid= 11747814 |doi=
*cite journal | author=Eisenberg I, Hochner H, Sadeh M, "et al." |title=Establishment of the genomic structure and identification of thirteen single-nucleotide polymorphisms in the human RECK gene. |journal=Cytogenet. Genome Res. |volume=97 |issue= 1-2 |pages= 58–61 |year= 2003 |pmid= 12438739 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Masui T, Doi R, Koshiba T, "et al." |title=RECK expression in pancreatic cancer: its correlation with lower invasiveness and better prognosis. |journal=Clin. Cancer Res. |volume=9 |issue= 5 |pages= 1779–84 |year= 2004 |pmid= 12738734 |doi=
*cite journal | author=Liu LT, Chang HC, Chiang LC, Hung WC |title=Histone deacetylase inhibitor up-regulates RECK to inhibit MMP-2 activation and cancer cell invasion. |journal=Cancer Res. |volume=63 |issue= 12 |pages= 3069–72 |year= 2003 |pmid= 12810630 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Humphray SJ, Oliver K, Hunt AR, "et al." |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465
*cite journal | author=Takeuchi T, Hisanaga M, Nagao M, "et al." |title=The membrane-anchored matrix metalloproteinase (MMP) regulator RECK in combination with MMP-9 serves as an informative prognostic indicator for colorectal cancer. |journal=Clin. Cancer Res. |volume=10 |issue= 16 |pages= 5572–9 |year= 2005 |pmid= 15328199 |doi= 10.1158/1078-0432.CCR-03-0656
*cite journal | author=Simizu S, Takagi S, Tamura Y, Osada H |title=RECK-mediated suppression of tumor cell invasion is regulated by glycosylation in human tumor cell lines. |journal=Cancer Res. |volume=65 |issue= 16 |pages= 7455–61 |year= 2005 |pmid= 16103099 |doi= 10.1158/0008-5472.CAN-04-4446
*cite journal | author=Hsu MC, Chang HC, Hung WC |title=HER-2/neu represses the metastasis suppressor RECK via ERK and Sp transcription factors to promote cell invasion. |journal=J. Biol. Chem. |volume=281 |issue= 8 |pages= 4718–25 |year= 2006 |pmid= 16377629 |doi= 10.1074/jbc. M510937200
*cite journal | author=Correa TC, Brohem CA, Winnischofer SM, "et al." |title=Downregulation of the RECK-tumor and metastasis suppressor gene in glioma invasiveness. |journal=J. Cell. Biochem. |volume=99 |issue= 1 |pages= 156–67 |year= 2006 |pmid= 16791855 |doi= 10.1002/jcb.20917
*cite journal | author=Chang HC, Cho CY, Hung WC |title=Silencing of the metastasis suppressor RECK by RAS oncogene is mediated by DNA methyltransferase 3b-induced promoter methylation. |journal=Cancer Res. |volume=66 |issue= 17 |pages= 8413–20 |year= 2007 |pmid= 16951151 |doi= 10.1158/0008-5472.CAN-06-0685
*cite journal | author=Lei H, Hemminki K, Altieri A, "et al." |title=Promoter polymorphisms in matrix metalloproteinases and their inhibitors: few associations with breast cancer susceptibility and progression. |journal=Breast Cancer Res. Treat. |volume=103 |issue= 1 |pages= 61–9 |year= 2007 |pmid= 17033924 |doi= 10.1007/s10549-006-9345-2
*cite journal | author=Chang HC, Cho CY, Hung WC |title=Downregulation of RECK by promoter methylation correlates with lymph node metastasis in non-small cell lung cancer. |journal=Cancer Sci. |volume=98 |issue= 2 |pages= 169–73 |year= 2007 |pmid= 17233834 |doi= 10.1111/j.1349-7006.2006.00367.x
*cite journal | author=Kang HG, Kim HS, Kim KJ, "et al." |title=RECK expression in osteosarcoma: correlation with matrix metalloproteinases activation and tumor invasiveness. |journal=J. Orthop. Res. |volume=25 |issue= 5 |pages= 696–702 |year= 2007 |pmid= 17262820 |doi= 10.1002/jor.20323
*cite journal | author=Mori T, Moriuchi R, Okazaki E, "et al." |title=Tgat oncoprotein functions as an inhibitor of RECK by association of the unique C-terminal region. |journal=Biochem. Biophys. Res. Commun. |volume=355 |issue= 4 |pages= 937–43 |year= 2007 |pmid= 17328864 |doi= 10.1016/j.bbrc.2007.02.051
*cite journal | author=Miki T, Takegami Y, Okawa K, "et al." |title=The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) interacts with membrane type 1 matrix metalloproteinase and CD13/aminopeptidase N and modulates their endocytic pathways. |journal=J. Biol. Chem. |volume=282 |issue= 16 |pages= 12341–52 |year= 2007 |pmid= 17329256 |doi= 10.1074/jbc. M610948200
*cite journal | author=Cho CY, Wang JH, Chang HC, "et al." |title=Epigenetic inactivation of the metastasis suppressor RECK enhances invasion of human colon cancer cells. |journal=J. Cell. Physiol. |volume=213 |issue= 1 |pages= 65–9 |year= 2007 |pmid= 17443689 |doi= 10.1002/jcp.21089

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  • Reck — (r[e^]k), v. t. [imp. & p. p. {Recked} (r[e^]kt) (obs. imp. {Roughte}); p. pr. & vb. n. {Recking}.] [AS. reccan, r[=e]can, to care for; akin to OS. r[=o]kian, OHG. ruochan, G. geruhen, Icel. r[ae]kja, also to E. reckon, rake an implement. See… …   The Collaborative International Dictionary of English

  • Reck — Sn erw. fach. (19. Jh.) Stammwort. Von Jahn 1816 als niederdeutsches Mundartwort aufgenommen und als Bezeichnung eines Turngeräts durchgesetzt. Mndd. rick, reck, mndl. rec(ke), ric, mhd. ric(ke) m. waagrecht aufgelegte oder aufgehängte Stange(n)… …   Etymologisches Wörterbuch der deutschen sprache

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  • Reck — Reck, eine der Gerätschaften beim Turnen, s.d …   Pierer's Universal-Lexikon

  • Reck — Reck, bekanntes Turngerät, bestehend aus einer an beiden Enden in Ständern befestigten Querstange; eingeführt, vielfach verwertet und mit dem im Niederdeutschen für Querstangen verschiedener Art gebräuchlichen Wort benannt vom Turnvater Jahn. Es… …   Meyers Großes Konversations-Lexikon

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