RECK

RECK

Reversion-inducing-cysteine-rich protein with kazal motifs, also known as RECK, is a human gene,cite web | title = Entrez Gene: RECK reversion-inducing-cysteine-rich protein with kazal motifs| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8434| accessdate = ] thought to be a metastasis suppressor.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis.cite web | title = Entrez Gene: RECK reversion-inducing-cysteine-rich protein with kazal motifs| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8434| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Takahashi C, Sheng Z, Horan TP, "et al." |title=Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 22 |pages= 13221–6 |year= 1998 |pmid= 9789069 |doi=
*cite journal | author=Gerstein M |title=Measurement of the effectiveness of transitive sequence comparison, through a third 'intermediate' sequence. |journal=Bioinformatics |volume=14 |issue= 8 |pages= 707–14 |year= 1998 |pmid= 9789096 |doi=
*cite journal | author=Oh J, Takahashi R, Kondo S, "et al." |title=The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. |journal=Cell |volume=107 |issue= 6 |pages= 789–800 |year= 2002 |pmid= 11747814 |doi=
*cite journal | author=Eisenberg I, Hochner H, Sadeh M, "et al." |title=Establishment of the genomic structure and identification of thirteen single-nucleotide polymorphisms in the human RECK gene. |journal=Cytogenet. Genome Res. |volume=97 |issue= 1-2 |pages= 58–61 |year= 2003 |pmid= 12438739 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Masui T, Doi R, Koshiba T, "et al." |title=RECK expression in pancreatic cancer: its correlation with lower invasiveness and better prognosis. |journal=Clin. Cancer Res. |volume=9 |issue= 5 |pages= 1779–84 |year= 2004 |pmid= 12738734 |doi=
*cite journal | author=Liu LT, Chang HC, Chiang LC, Hung WC |title=Histone deacetylase inhibitor up-regulates RECK to inhibit MMP-2 activation and cancer cell invasion. |journal=Cancer Res. |volume=63 |issue= 12 |pages= 3069–72 |year= 2003 |pmid= 12810630 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Humphray SJ, Oliver K, Hunt AR, "et al." |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465
*cite journal | author=Takeuchi T, Hisanaga M, Nagao M, "et al." |title=The membrane-anchored matrix metalloproteinase (MMP) regulator RECK in combination with MMP-9 serves as an informative prognostic indicator for colorectal cancer. |journal=Clin. Cancer Res. |volume=10 |issue= 16 |pages= 5572–9 |year= 2005 |pmid= 15328199 |doi= 10.1158/1078-0432.CCR-03-0656
*cite journal | author=Simizu S, Takagi S, Tamura Y, Osada H |title=RECK-mediated suppression of tumor cell invasion is regulated by glycosylation in human tumor cell lines. |journal=Cancer Res. |volume=65 |issue= 16 |pages= 7455–61 |year= 2005 |pmid= 16103099 |doi= 10.1158/0008-5472.CAN-04-4446
*cite journal | author=Hsu MC, Chang HC, Hung WC |title=HER-2/neu represses the metastasis suppressor RECK via ERK and Sp transcription factors to promote cell invasion. |journal=J. Biol. Chem. |volume=281 |issue= 8 |pages= 4718–25 |year= 2006 |pmid= 16377629 |doi= 10.1074/jbc. M510937200
*cite journal | author=Correa TC, Brohem CA, Winnischofer SM, "et al." |title=Downregulation of the RECK-tumor and metastasis suppressor gene in glioma invasiveness. |journal=J. Cell. Biochem. |volume=99 |issue= 1 |pages= 156–67 |year= 2006 |pmid= 16791855 |doi= 10.1002/jcb.20917
*cite journal | author=Chang HC, Cho CY, Hung WC |title=Silencing of the metastasis suppressor RECK by RAS oncogene is mediated by DNA methyltransferase 3b-induced promoter methylation. |journal=Cancer Res. |volume=66 |issue= 17 |pages= 8413–20 |year= 2007 |pmid= 16951151 |doi= 10.1158/0008-5472.CAN-06-0685
*cite journal | author=Lei H, Hemminki K, Altieri A, "et al." |title=Promoter polymorphisms in matrix metalloproteinases and their inhibitors: few associations with breast cancer susceptibility and progression. |journal=Breast Cancer Res. Treat. |volume=103 |issue= 1 |pages= 61–9 |year= 2007 |pmid= 17033924 |doi= 10.1007/s10549-006-9345-2
*cite journal | author=Chang HC, Cho CY, Hung WC |title=Downregulation of RECK by promoter methylation correlates with lymph node metastasis in non-small cell lung cancer. |journal=Cancer Sci. |volume=98 |issue= 2 |pages= 169–73 |year= 2007 |pmid= 17233834 |doi= 10.1111/j.1349-7006.2006.00367.x
*cite journal | author=Kang HG, Kim HS, Kim KJ, "et al." |title=RECK expression in osteosarcoma: correlation with matrix metalloproteinases activation and tumor invasiveness. |journal=J. Orthop. Res. |volume=25 |issue= 5 |pages= 696–702 |year= 2007 |pmid= 17262820 |doi= 10.1002/jor.20323
*cite journal | author=Mori T, Moriuchi R, Okazaki E, "et al." |title=Tgat oncoprotein functions as an inhibitor of RECK by association of the unique C-terminal region. |journal=Biochem. Biophys. Res. Commun. |volume=355 |issue= 4 |pages= 937–43 |year= 2007 |pmid= 17328864 |doi= 10.1016/j.bbrc.2007.02.051
*cite journal | author=Miki T, Takegami Y, Okawa K, "et al." |title=The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) interacts with membrane type 1 matrix metalloproteinase and CD13/aminopeptidase N and modulates their endocytic pathways. |journal=J. Biol. Chem. |volume=282 |issue= 16 |pages= 12341–52 |year= 2007 |pmid= 17329256 |doi= 10.1074/jbc. M610948200
*cite journal | author=Cho CY, Wang JH, Chang HC, "et al." |title=Epigenetic inactivation of the metastasis suppressor RECK enhances invasion of human colon cancer cells. |journal=J. Cell. Physiol. |volume=213 |issue= 1 |pages= 65–9 |year= 2007 |pmid= 17443689 |doi= 10.1002/jcp.21089

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  • Reck — [rɛk], das; [e]s, e, auch: s: Turngerät, das aus einer zwischen zwei festen senkrechten Stützen angebrachten stählernen Stange besteht: eine Felge am Reck machen; mit einem doppelten Salto vom Reck abgehen. * * * Rẹck 〈n. 11; Sp.〉 1. Turngerät,… …   Universal-Lexikon

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  • Reck — (r[e^]k), v. i. To make account; to take heed; to care; to mind; often followed by of. [Archaic] [1913 Webster] Then reck I not, when I have lost my life. Chaucer. [1913 Webster] I reck not though I end my life to day. Shak. [1913 Webster] Of me… …   The Collaborative International Dictionary of English

  • Reck — (r[e^]k), v. t. [imp. & p. p. {Recked} (r[e^]kt) (obs. imp. {Roughte}); p. pr. & vb. n. {Recking}.] [AS. reccan, r[=e]can, to care for; akin to OS. r[=o]kian, OHG. ruochan, G. geruhen, Icel. r[ae]kja, also to E. reckon, rake an implement. See… …   The Collaborative International Dictionary of English

  • Reck — Sn erw. fach. (19. Jh.) Stammwort. Von Jahn 1816 als niederdeutsches Mundartwort aufgenommen und als Bezeichnung eines Turngeräts durchgesetzt. Mndd. rick, reck, mndl. rec(ke), ric, mhd. ric(ke) m. waagrecht aufgelegte oder aufgehängte Stange(n)… …   Etymologisches Wörterbuch der deutschen sprache

  • reck — O.E. reccan, from P.Gmc. *rokjan (see RECKLESS (Cf. reckless)) “From its earliest appearance in Eng., reck is almost exclusively employed in negative or interrogative clauses” [OED]. Related: Recked; recking. As a noun, from 1560s …   Etymology dictionary

  • Reck — Reck: Die Bezeichnung des Turngerätes wurde zu Beginn des 19. Jh.s von F. L. Jahn in die Turnersprache eingeführt, und zwar aus dem Niederd., wo ‹m›niederd. reck‹e› eine Querstange zum Aufhängen der Wäsche, zum Aufsitzen der Hühner oder dgl.… …   Das Herkunftswörterbuch

  • reck — sb., en, er, erne (et gymnastikredskab), i sms. reck , fx reckøvelse …   Dansk ordbog

  • Reck — Reck, eine der Gerätschaften beim Turnen, s.d …   Pierer's Universal-Lexikon

  • Reck — Reck, bekanntes Turngerät, bestehend aus einer an beiden Enden in Ständern befestigten Querstange; eingeführt, vielfach verwertet und mit dem im Niederdeutschen für Querstangen verschiedener Art gebräuchlichen Wort benannt vom Turnvater Jahn. Es… …   Meyers Großes Konversations-Lexikon

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