TRIM25

Tripartite motif-containing 25, also known as TRIM25, is a human gene.cite web | title = Entrez Gene: TRIM25 tripartite motif-containing 25| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7706| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene.cite web | title = Entrez Gene: TRIM25 tripartite motif-containing 25| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7706| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Horie K, Urano T, Ikeda K, Inoue S |title=Estrogen-responsive RING finger protein controls breast cancer growth. |journal=J. Steroid Biochem. Mol. Biol. |volume=85 |issue= 2-5 |pages= 101–4 |year= 2003 |pmid= 12943693 |doi=
*cite journal | author=Inoue S, Orimo A, Matsuda Y, "et al." |title=Chromosome mapping of human (ZNF147) and mouse genes for estrogen-responsive finger protein (efp), a member of the RING finger family. |journal=Genomics |volume=25 |issue= 2 |pages= 581–3 |year= 1995 |pmid= 7789997 |doi=
*cite journal | author=Inoue S, Orimo A, Hosoi T, "et al." |title=Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 23 |pages= 11117–21 |year= 1994 |pmid= 8248217 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Ikeda K, Inoue S, Orimo A, "et al." |title=Multiple regulatory elements and binding proteins of the 5'-flanking region of the human estrogen-responsive finger protein (efp) gene. |journal=Biochem. Biophys. Res. Commun. |volume=236 |issue= 3 |pages= 765–71 |year= 1997 |pmid= 9245730 |doi= 10.1006/bbrc.1997.7046
*cite journal | author=Ikeda K, Orimo A, Higashi Y, "et al." |title=Efp as a primary estrogen-responsive gene in human breast cancer. |journal=FEBS Lett. |volume=472 |issue= 1 |pages= 9–13 |year= 2000 |pmid= 10781795 |doi=
*cite journal | author=Reymond A, Meroni G, Fantozzi A, "et al." |title=The tripartite motif family identifies cell compartments. |journal=EMBO J. |volume=20 |issue= 9 |pages= 2140–51 |year= 2001 |pmid= 11331580 |doi= 10.1093/emboj/20.9.2140
*cite journal | author=Urano T, Saito T, Tsukui T, "et al." |title=Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth. |journal=Nature |volume=417 |issue= 6891 |pages= 871–5 |year= 2002 |pmid= 12075357 |doi= 10.1038/nature00826
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Shimada N, Suzuki T, Inoue S, "et al." |title=Systemic distribution of estrogen-responsive finger protein (Efp) in human tissues. |journal=Mol. Cell. Endocrinol. |volume=218 |issue= 1-2 |pages= 147–53 |year= 2004 |pmid= 15130519 |doi= 10.1016/j.mce.2003.12.008
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rush J, Moritz A, Lee KA, "et al." |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046
*cite journal | author=Suzuki T, Urano T, Tsukui T, "et al." |title=Estrogen-responsive finger protein as a new potential biomarker for breast cancer. |journal=Clin. Cancer Res. |volume=11 |issue= 17 |pages= 6148–54 |year= 2005 |pmid= 16144914 |doi= 10.1158/1078-0432.CCR-05-0040
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Nakayama H, Sano T, Motegi A, "et al." |title=Increasing 14-3-3 sigma expression with declining estrogen receptor alpha and estrogen-responsive finger protein expression defines malignant progression of endometrial carcinoma. |journal=Pathol. Int. |volume=55 |issue= 11 |pages= 707–15 |year= 2005 |pmid= 16271083 |doi= 10.1111/j.1440-1827.2005.01900.x
*cite journal | author=Nakasato N, Ikeda K, Urano T, "et al." |title=A ubiquitin E3 ligase Efp is up-regulated by interferons and conjugated with ISG15. |journal=Biochem. Biophys. Res. Commun. |volume=351 |issue= 2 |pages= 540–6 |year= 2007 |pmid= 17069755 |doi= 10.1016/j.bbrc.2006.10.061
*cite journal | author=Nakajima A, Maruyama S, Bohgaki M, "et al." |title=Ligand-dependent transcription of estrogen receptor alpha is mediated by the ubiquitin ligase EFP. |journal=Biochem. Biophys. Res. Commun. |volume=357 |issue= 1 |pages= 245–51 |year= 2007 |pmid= 17418098 |doi= 10.1016/j.bbrc.2007.03.134

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