ITPKA

Inositol 1,4,5-trisphosphate 3-kinase A, also known as ITPKA, is a human gene.cite web | title = Entrez Gene: ITPKA inositol 1,4,5-trisphosphate 3-kinase A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3706| accessdate = ]

PBB_Summary
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summary_text = Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro. ITPKA and ITPKB are 68% identical in the C-terminus region.cite web | title = Entrez Gene: ITPKA inositol 1,4,5-trisphosphate 3-kinase A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3706| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Erneux C, Roeckel N, Takazawa K, "et al." |title=Localization of the genes for human inositol 1,4,5-trisphosphate 3-kinase A (ITPKA) and B (ITPKB) to chromosome regions 15q14-q21 and 1q41-q43, respectively, by in situ hybridization. |journal=Genomics |volume=14 |issue= 2 |pages= 546–7 |year= 1992 |pmid= 1330886 |doi=
*cite journal | author=Takazawa K, Perret J, Dumont JE, Erneux C |title=Molecular cloning and expression of a new putative inositol 1,4,5-trisphosphate 3-kinase isoenzyme. |journal=Biochem. J. |volume=278 ( Pt 3) |issue= |pages= 883–6 |year= 1991 |pmid= 1654894 |doi=
*cite journal | author=Takazawa K, Erneux C |title=Identification of residues essential for catalysis and binding of calmodulin in rat brain inositol 1,4,5-trisphosphate 3-kinase. |journal=Biochem. J. |volume=280 ( Pt 1) |issue= |pages= 125–9 |year= 1992 |pmid= 1660262 |doi=
*cite journal | author=Takazawa K, Perret J, Dumont JE, Erneux C |title=Molecular cloning and expression of a human brain inositol 1,4,5-trisphosphate 3-kinase. |journal=Biochem. Biophys. Res. Commun. |volume=174 |issue= 2 |pages= 529–35 |year= 1991 |pmid= 1847047 |doi=
*cite journal | author=Lin AN, Barnes S, Wallace RW |title=Phosphorylation by protein kinase C inactivates an inositol 1,4,5-trisphosphate 3-kinase purified from human platelets. |journal=Biochem. Biophys. Res. Commun. |volume=170 |issue= 3 |pages= 1371–6 |year= 1990 |pmid= 2167676 |doi=
*cite journal | author=Takazawa K, Perret J, Dumont JE, Erneux C |title=Human brain inositol 1,4,5-trisphosphate 3-kinase cDNA sequence. |journal=Nucleic Acids Res. |volume=18 |issue= 23 |pages= 7141 |year= 1991 |pmid= 2175886 |doi=
*cite journal | author=Takazawa K, Vandekerckhove J, Dumont JE, Erneux C |title=Cloning and expression in Escherichia coli of a rat brain cDNA encoding a Ca2+/calmodulin-sensitive inositol 1,4,5-trisphosphate 3-kinase. |journal=Biochem. J. |volume=272 |issue= 1 |pages= 107–12 |year= 1991 |pmid= 2176078 |doi=
*cite journal | author=Ryu SH, Lee SY, Lee KY, Rhee SG |title=Catalytic properties of inositol trisphosphate kinase: activation by Ca2+ and calmodulin. |journal=FASEB J. |volume=1 |issue= 5 |pages= 388–93 |year= 1987 |pmid= 2824270 |doi=
*cite journal | author=Communi D, Vanweyenberg V, Erneux C |title=D-myo-inositol 1,4,5-trisphosphate 3-kinase A is activated by receptor activation through a calcium:calmodulin-dependent protein kinase II phosphorylation mechanism. |journal=EMBO J. |volume=16 |issue= 8 |pages= 1943–52 |year= 1997 |pmid= 9155020 |doi= 10.1093/emboj/16.8.1943
*cite journal | author=Woodring PJ, Garrison JC |title=Expression, purification, and regulation of two isoforms of the inositol 1,4,5-trisphosphate 3-kinase. |journal=J. Biol. Chem. |volume=272 |issue= 48 |pages= 30447–54 |year= 1997 |pmid= 9374536 |doi=
*cite journal | author=Schell MJ, Erneux C, Irvine RF |title=Inositol 1,4,5-trisphosphate 3-kinase A associates with F-actin and dendritic spines via its N terminus. |journal=J. Biol. Chem. |volume=276 |issue= 40 |pages= 37537–46 |year= 2001 |pmid= 11468283 |doi= 10.1074/jbc.M104101200
*cite journal | author=Mishra J, Bhalla US |title=Simulations of inositol phosphate metabolism and its interaction with InsP(3)-mediated calcium release. |journal=Biophys. J. |volume=83 |issue= 3 |pages= 1298–316 |year= 2003 |pmid= 12202356 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Dewaste V, Moreau C, De Smedt F, "et al." |title=The three isoenzymes of human inositol-1,4,5-trisphosphate 3-kinase show specific intracellular localization but comparable Ca2+ responses on transfection in COS-7 cells. |journal=Biochem. J. |volume=374 |issue= Pt 1 |pages= 41–9 |year= 2003 |pmid= 12747803 |doi= 10.1042/BJ20021963
*cite journal | author=González B, Schell MJ, Letcher AJ, "et al." |title=Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase. |journal=Mol. Cell |volume=15 |issue= 5 |pages= 689–701 |year= 2004 |pmid= 15350214 |doi= 10.1016/j.molcel.2004.08.004
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kato H, Uzawa K, Onda T, "et al." |title=Down-regulation of 1D-myo-inositol 1,4,5-trisphosphate 3-kinase A protein expression in oral squamous cell carcinoma. |journal=Int. J. Oncol. |volume=28 |issue= 4 |pages= 873–81 |year= 2006 |pmid= 16525636 |doi=

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