PHC1

Polyhomeotic homolog 1 (Drosophila), also known as PHC1, is a human gene.cite web | title = Entrez Gene: PHC1 polyhomeotic homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1911| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein.cite web | title = Entrez Gene: PHC1 polyhomeotic homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1911| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Alkema MJ, Bronk M, Verhoeven E, "et al." |title=Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian polycomb complex. |journal=Genes Dev. |volume=11 |issue= 2 |pages= 226–40 |year= 1997 |pmid= 9009205 |doi=
*cite journal | author=Gunster MJ, Satijn DP, Hamer KM, "et al." |title=Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic. |journal=Mol. Cell. Biol. |volume=17 |issue= 4 |pages= 2326–35 |year= 1997 |pmid= 9121482 |doi=
*cite journal | author=Satijn DP, Gunster MJ, van der Vlag J, "et al." |title=RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor. |journal=Mol. Cell. Biol. |volume=17 |issue= 7 |pages= 4105–13 |year= 1997 |pmid= 9199346 |doi=
*cite journal | author=Tomotsune D, Takihara Y, Berger J, "et al." |title=A novel member of murine Polycomb-group proteins, Sex comb on midleg homolog protein, is highly conserved, and interacts with RAE28/mph1 in vitro. |journal=Differentiation |volume=65 |issue= 4 |pages= 229–39 |year= 2000 |pmid= 10653359 |doi=
*cite journal | author=Ohta H, Tokimasa S, Zou Z, "et al." |title=Structure and chromosomal localization of the RAE28/HPH1 gene, a human homologue of the polyhomeotic gene. |journal=DNA Seq. |volume=11 |issue= 1-2 |pages= 61–73 |year= 2000 |pmid= 10902910 |doi=
*cite journal | author=Levine SS, Weiss A, Erdjument-Bromage H, "et al." |title=The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. |journal=Mol. Cell. Biol. |volume=22 |issue= 17 |pages= 6070–8 |year= 2002 |pmid= 12167701 |doi=
*cite journal | author=Suzuki M, Mizutani-Koseki Y, Fujimura Y, "et al." |title=Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice. |journal=Development |volume=129 |issue= 18 |pages= 4171–83 |year= 2002 |pmid= 12183370 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Luo L, Yang X, Takihara Y, "et al." |title=The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions. |journal=Nature |volume=427 |issue= 6976 |pages= 749–53 |year= 2004 |pmid= 14973489 |doi= 10.1038/nature02305
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Wang H, Wang L, Erdjument-Bromage H, "et al." |title=Role of histone H2A ubiquitination in Polycomb silencing. |journal=Nature |volume=431 |issue= 7010 |pages= 873–8 |year= 2004 |pmid= 15386022 |doi= 10.1038/nature02985
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Voncken JW, Niessen H, Neufeld B, "et al." |title=MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1. |journal=J. Biol. Chem. |volume=280 |issue= 7 |pages= 5178–87 |year= 2005 |pmid= 15563468 |doi= 10.1074/jbc.M407155200
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209

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