JMJD6

Jumonji domain containing 6, also known as JMJD6, is a human gene.cite web | title = Entrez Gene: JMJD6 jumonji domain containing 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23210| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have suggested that the protein may cross-react with a monoclonal antibody that recognizes the phosphatidylserine receptor and does not directly function in the clearance of apoptotic cells. Multiple transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: JMJD6 jumonji domain containing 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23210| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Williamson P, Schlegel RA |title=Hide and seek: the secret identity of the phosphatidylserine receptor. |journal=J. Biol. |volume=3 |issue= 4 |pages= 14 |year= 2005 |pmid= 15453906 |doi= 10.1186/jbiol14
*cite journal | author=Nagase T, Ishikawa K, Miyajima N, "et al." |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 1 |pages= 31–9 |year= 1998 |pmid= 9628581 |doi=
*cite journal | author=Fadok VA, Bratton DL, Rose DM, "et al." |title=A receptor for phosphatidylserine-specific clearance of apoptotic cells. |journal=Nature |volume=405 |issue= 6782 |pages= 85–90 |year= 2000 |pmid= 10811223 |doi= 10.1038/35011084
*cite journal | author=Vandivier RW, Fadok VA, Hoffmann PR, "et al." |title=Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. |journal=J. Clin. Invest. |volume=109 |issue= 5 |pages= 661–70 |year= 2002 |pmid= 11877474 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ajmone-Cat MA, De Simone R, Nicolini A, Minghetti L |title=Effects of phosphatidylserine on p38 mitogen activated protein kinase, cyclic AMP responding element binding protein and nuclear factor-kappaB activation in resting and activated microglial cells. |journal=J. Neurochem. |volume=84 |issue= 2 |pages= 413–6 |year= 2003 |pmid= 12559004 |doi=
*cite journal | author=Chan A, Seguin R, Magnus T, "et al." |title=Phagocytosis of apoptotic inflammatory cells by microglia and its therapeutic implications: termination of CNS autoimmune inflammation and modulation by interferon-beta. |journal=Glia |volume=43 |issue= 3 |pages= 231–42 |year= 2003 |pmid= 12898702 |doi= 10.1002/glia.10258
*cite journal | author=Wang X, Wu YC, Fadok VA, "et al." |title=Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12. |journal=Science |volume=302 |issue= 5650 |pages= 1563–6 |year= 2003 |pmid= 14645848 |doi= 10.1126/science.1087641
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Cui P, Qin B, Liu N, "et al." |title=Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals. |journal=Exp. Cell Res. |volume=293 |issue= 1 |pages= 154–63 |year= 2004 |pmid= 14729065 |doi=
*cite journal | author=Cao WM, Murao K, Imachi H, "et al." |title=Phosphatidylserine receptor cooperates with high-density lipoprotein receptor in recognition of apoptotic cells by thymic nurse cells. |journal=J. Mol. Endocrinol. |volume=32 |issue= 2 |pages= 497–505 |year= 2005 |pmid= 15072554 |doi=
*cite journal | author=Cikala M, Alexandrova O, David CN, "et al." |title=The phosphatidylserine receptor from Hydra is a nuclear protein with potential Fe(II) dependent oxygenase activity. |journal=BMC Cell Biol. |volume=5 |issue= |pages= 26 |year= 2004 |pmid= 15193161 |doi= 10.1186/1471-2121-5-26
*cite journal | author=Böse J, Gruber AD, Helming L, "et al." |title=The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal. |journal=J. Biol. |volume=3 |issue= 4 |pages= 15 |year= 2005 |pmid= 15345036 |doi= 10.1186/jbiol10
*cite journal | author=Hong JR, Lin GH, Lin CJ, "et al." |title=Phosphatidylserine receptor is required for the engulfment of dead apoptotic cells and for normal embryonic development in zebrafish. |journal=Development |volume=131 |issue= 21 |pages= 5417–27 |year= 2004 |pmid= 15469976 |doi= 10.1242/dev.01409
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Köninger J, Balaz P, Wagner M, "et al." |title=Phosphatidylserine receptor in chronic pancreatitis: evidence for a macrophage independent role. |journal=Ann. Surg. |volume=241 |issue= 1 |pages= 144–51 |year= 2005 |pmid= 15622002 |doi=
*cite journal | author=Klose RJ, Kallin EM, Zhang Y |title=JmjC-domain-containing proteins and histone demethylation. |journal=Nat. Rev. Genet. |volume=7 |issue= 9 |pages= 715–27 |year= 2006 |pmid= 16983801 |doi=
*cite journal | author=Chang B, Chen Y, Zhao Y, Bruick RK |title=JMJD6 is a histone arginine demethylase. |journal=Science |volume=318 |issue= 5849 |pages= 444–7 |year= 2007 |pmid= 17947579 |doi= 10.1126/science.1145801

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