SLAMF6

SLAM family member 6, also known as SLAMF6, is a human gene.cite web | title = Entrez Gene: SLAMF6 SLAM family member 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114836| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.cite web | title = Entrez Gene: SLAMF6 SLAM family member 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114836| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Claus M, Meinke S, Bhat R, Watzl C |title=Regulation of NK cell activity by 2B4, NTB-A and CRACC. |journal=Front. Biosci. |volume=13 |issue= |pages= 956–65 |year= 2007 |pmid= 17981603 |doi=
*cite journal | author=Hercend T, Meuer S, Brennan A, "et al." |title=Natural killer-like function of activated T lymphocytes: differential blocking effects of monoclonal antibodies specific for a 90-kDa clonotypic structure. |journal=Cell. Immunol. |volume=86 |issue= 2 |pages= 381–92 |year= 1984 |pmid= 6610481 |doi=
*cite journal | author=Kong G, Dalton M, Wardenburg JB, "et al." |title=Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function. |journal=Mol. Cell. Biol. |volume=16 |issue= 9 |pages= 5026–35 |year= 1996 |pmid= 8756661 |doi=
*cite journal | author=Lee YJ, Luisiri P, Clark MR |title=A novel complex, p40/42, is constitutively associated with the B cell antigen receptor and phosphorylated upon receptor stimulation. |journal=J. Immunol. |volume=157 |issue= 9 |pages= 3828–37 |year= 1996 |pmid= 8892612 |doi=
*cite journal | author=Gray CW, Ward RV, Karran E, "et al." |title=Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response. |journal=Eur. J. Biochem. |volume=267 |issue= 18 |pages= 5699–710 |year= 2000 |pmid= 10971580 |doi=
*cite journal | author=Bottino C, Falco M, Parolini S, "et al." |title=NTB-A [correction of GNTB-A] , a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease. |journal=J. Exp. Med. |volume=194 |issue= 3 |pages= 235–46 |year= 2001 |pmid= 11489943 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Del Valle JM, Engel P, Martín M |title=The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2). |journal=J. Biol. Chem. |volume=278 |issue= 19 |pages= 17430–7 |year= 2003 |pmid= 12621057 |doi= 10.1074/jbc.M301569200
*cite journal | author=Tangye SG, Nichols KE, Hare NJ, van de Weerdt BC |title=Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation. |journal=J. Immunol. |volume=171 |issue= 5 |pages= 2485–95 |year= 2003 |pmid= 12928397 |doi=
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Valdez PA, Wang H, Seshasayee D, "et al." |title=NTB-A, a new activating receptor in T cells that regulates autoimmune disease. |journal=J. Biol. Chem. |volume=279 |issue= 18 |pages= 18662–9 |year= 2004 |pmid= 14988414 |doi= 10.1074/jbc.M312313200
*cite journal | author=Flaig RM, Stark S, Watzl C |title=Cutting edge: NTB-A activates NK cells via homophilic interaction. |journal=J. Immunol. |volume=172 |issue= 11 |pages= 6524–7 |year= 2004 |pmid= 15153464 |doi=
*cite journal | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Stark S, Watzl C |title=2B4 (CD244), NTB-A and CRACC (CS1) stimulate cytotoxicity but no proliferation in human NK cells. |journal=Int. Immunol. |volume=18 |issue= 2 |pages= 241–7 |year= 2006 |pmid= 16410313 |doi= 10.1093/intimm/dxh358
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727
*cite journal | author=Eissmann P, Watzl C |title=Molecular analysis of NTB-A signaling: a role for EAT-2 in NTB-A-mediated activation of human NK cells. |journal=J. Immunol. |volume=177 |issue= 5 |pages= 3170–7 |year= 2006 |pmid= 16920955 |doi=
*cite journal | author=Cao E, Ramagopal UA, Fedorov A, "et al." |title=NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family. |journal=Immunity |volume=25 |issue= 4 |pages= 559–70 |year= 2006 |pmid= 17045824 |doi= 10.1016/j.immuni.2006.06.020
*cite journal | author=Banerjee P, Feuer G, Barker E |title=Human T-cell leukemia virus type 1 (HTLV-1) p12I down-modulates ICAM-1 and -2 and reduces adherence of natural killer cells, thereby protecting HTLV-1-infected primary CD4+ T cells from autologous natural killer cell-mediated cytotoxicity despite the reduction of major histocompatibility complex class I molecules on infected cells. |journal=J. Virol. |volume=81 |issue= 18 |pages= 9707–17 |year= 2007 |pmid= 17609265 |doi= 10.1128/JVI.00887-07

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