PLCD3

Phospholipase C, delta 3, also known as PLCD3, is a human gene.cite web | title = Entrez Gene: PLCD3 phospholipase C, delta 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=113026| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids.cite web | title = Entrez Gene: PLCD3 phospholipase C, delta 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=113026| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Cefai D, Debre P, Kaczorek M, "et al." |title=Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway. |journal=J. Clin. Invest. |volume=86 |issue= 6 |pages= 2117–24 |year= 1991 |pmid= 1979339 |doi=
*cite journal | author=Zauli G, Previati M, Caramelli E, "et al." |title=Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line. |journal=Eur. J. Immunol. |volume=25 |issue= 9 |pages= 2695–700 |year= 1995 |pmid= 7589147 |doi=
*cite journal | author=Ghosh S, Pawelczyk T, Lowenstein JM |title=Phospholipase C isoforms delta 1 and delta 3 from human fibroblasts. High-yield expression in Escherichia coli, simple purification, and properties. |journal=Protein Expr. Purif. |volume=9 |issue= 2 |pages= 262–78 |year= 1997 |pmid= 9056492 |doi=
*cite journal | author=Chen P, Mayne M, Power C, Nath A |title=The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases. |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22385–8 |year= 1997 |pmid= 9278385 |doi=
*cite journal | author=Pawełczyk T, Matecki A |title=Expression, purification and kinetic properties of human recombinant phospholipase C delta 3. |journal=Acta Biochim. Pol. |volume=44 |issue= 2 |pages= 221–9 |year= 1998 |pmid= 9360711 |doi=
*cite journal | author=Mayne M, Bratanich AC, Chen P, "et al." |title=HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease. |journal=Neuroimmunomodulation |volume=5 |issue= 3-4 |pages= 184–92 |year= 1998 |pmid= 9730685 |doi=
*cite journal | author=Pawelczyk T, Matecki A |title=Localization of phospholipase C delta3 in the cell and regulation of its activity by phospholipids and calcium. |journal=Eur. J. Biochem. |volume=257 |issue= 1 |pages= 169–77 |year= 1998 |pmid= 9799116 |doi=
*cite journal | author=Pawelczyk T, Matecki A |title=Phospholipase C-delta3 binds with high specificity to phosphatidylinositol 4,5-bisphosphate and phosphatidic acid in bilayer membranes. |journal=Eur. J. Biochem. |volume=262 |issue= 2 |pages= 291–8 |year= 1999 |pmid= 10336610 |doi=
*cite journal | author=Haughey NJ, Holden CP, Nath A, Geiger JD |title=Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat. |journal=J. Neurochem. |volume=73 |issue= 4 |pages= 1363–74 |year= 1999 |pmid= 10501179 |doi=
*cite journal | author=Kim H, Suh PG, Ryu SH, Park SH |title=Assignment of the human PLC delta3 gene (PLCD3) to human chromosome band 17q21 by fluorescence in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=87 |issue= 3-4 |pages= 209–10 |year= 2000 |pmid= 10702670 |doi=
*cite journal | author=Mayne M, Holden CP, Nath A, Geiger JD |title=Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages. |journal=J. Immunol. |volume=164 |issue= 12 |pages= 6538–42 |year= 2000 |pmid= 10843712 |doi=
*cite journal | author=Lin FG, Cheng HF, Lee IF, "et al." |title=Downregulation of phospholipase C delta3 by cAMP and calcium. |journal=Biochem. Biophys. Res. Commun. |volume=286 |issue= 2 |pages= 274–80 |year= 2001 |pmid= 11500033 |doi= 10.1006/bbrc.2001.5371
*cite journal | author=Ananthanarayanan B, Das S, Rhee SG, "et al." |title=Membrane targeting of C2 domains of phospholipase C-delta isoforms. |journal=J. Biol. Chem. |volume=277 |issue= 5 |pages= 3568–75 |year= 2002 |pmid= 11706040 |doi= 10.1074/jbc.M109705200
*cite journal | author=Nagase T, Kikuno R, Ohara O |title=Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. |journal=DNA Res. |volume=8 |issue= 6 |pages= 319–27 |year= 2002 |pmid= 11853319 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Bennasser Y, Badou A, Tkaczuk J, Bahraoui E |title=Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha. |journal=Virology |volume=303 |issue= 1 |pages= 174–80 |year= 2003 |pmid= 12482669 |doi=
*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406

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