FGF18

Fibroblast growth factor 18, also known as FGF18, is a human gene.cite web | title = Entrez Gene: FGF18 fibroblast growth factor 18| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8817| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures.cite web | title = Entrez Gene: FGF18 fibroblast growth factor 18| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8817| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Haque T, Nakada S, Hamdy RC |title=A review of FGF18: Its expression, signaling pathways and possible functions during embryogenesis and post-natal development. |journal=Histol. Histopathol. |volume=22 |issue= 1 |pages= 97–105 |year= 2007 |pmid= 17128416 |doi=
*cite journal | author=Ohbayashi N, Hoshikawa M, Kimura S, "et al." |title=Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18. |journal=J. Biol. Chem. |volume=273 |issue= 29 |pages= 18161–4 |year= 1998 |pmid= 9660775 |doi=
*cite journal | author=Hu MC, Qiu WR, Wang YP, "et al." |title=FGF-18, a novel member of the fibroblast growth factor family, stimulates hepatic and intestinal proliferation. |journal=Mol. Cell. Biol. |volume=18 |issue= 10 |pages= 6063–74 |year= 1998 |pmid= 9742123 |doi=
*cite journal | author=Hu MC, Wang YP, Qiu WR |title=Human fibroblast growth factor-18 stimulates fibroblast cell proliferation and is mapped to chromosome 14p11. |journal=Oncogene |volume=18 |issue= 16 |pages= 2635–42 |year= 1999 |pmid= 10353607 |doi= 10.1038/sj.onc.1202616
*cite journal | author=Xu J, Liu Z, Ornitz DM |title=Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures. |journal=Development |volume=127 |issue= 9 |pages= 1833–43 |year= 2000 |pmid= 10751172 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Whitmore TE, Maurer MF, Sexson S, "et al." |title=Assignment of fibroblast growth factor 18 (FGF18) to human chromosome 5q34 by use of radiation hybrid mapping and fluorescence in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=90 |issue= 3-4 |pages= 231–3 |year= 2001 |pmid= 11124520 |doi=
*cite journal | author=Simpson JC, Wellenreuther R, Poustka A, "et al." |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Popovici C, Conchonaud F, Birnbaum D, Roubin R |title=Functional phylogeny relates LET-756 to fibroblast growth factor 9. |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 40146–52 |year= 2004 |pmid= 15199049 |doi= 10.1074/jbc.M405795200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Wiemann S, Arlt D, Huber W, "et al." |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704
*cite journal | author=Cormier S, Leroy C, Delezoide AL, Silve C |title=Expression of fibroblast growth factors 18 and 23 during human embryonic and fetal development. |journal=Gene Expr. Patterns |volume=5 |issue= 4 |pages= 569–73 |year= 2005 |pmid= 15749088 |doi= 10.1016/j.modgep.2004.10.008
*cite journal | author=Antoine M, Wirz W, Tag CG, "et al." |title=Expression pattern of fibroblast growth factors (FGFs), their receptors and antagonists in primary endothelial cells and vascular smooth muscle cells. |journal=Growth Factors |volume=23 |issue= 2 |pages= 87–95 |year= 2005 |pmid= 16019430 |doi= 10.1080/08977190500096004
*cite journal | author=Mehrle A, Rosenfelder H, Schupp I, "et al." |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139
*cite journal | author=Antoine M, Wirz W, Tag CG, "et al." |title=Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation. |journal=Biochem. Biophys. Res. Commun. |volume=346 |issue= 1 |pages= 224–33 |year= 2006 |pmid= 16756958 |doi= 10.1016/j.bbrc.2006.05.105
*cite journal | author=Riley BM, Mansilla MA, Ma J, "et al." |title=Impaired FGF signaling contributes to cleft lip and palate. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 11 |pages= 4512–7 |year= 2007 |pmid= 17360555 |doi= 10.1073/pnas.0607956104

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