RNF216

TRIAD3 protein, also known as TRIAD3, is a human gene.cite web | title = Entrez Gene: TRIAD3 TRIAD3 protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54476| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known.cite web | title = Entrez Gene: TRIAD3 TRIAD3 protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54476| accessdate = ]

ee also

* RING finger domain

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lake JA, Carr J, Feng F, "et al." |title=The role of Vif during HIV-1 infection: interaction with novel host cellular factors. |journal=J. Clin. Virol. |volume=26 |issue= 2 |pages= 143–52 |year= 2003 |pmid= 12600646 |doi=
*cite journal | author=Matoba R, Okubo K, Hori N, "et al." |title=The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression. |journal=Gene |volume=146 |issue= 2 |pages= 199–207 |year= 1994 |pmid= 8076819 |doi=
*cite journal | author=van der Reijden BA, Erpelinck-Verschueren CA, Löwenberg B, Jansen JH |title=TRIADs: a new class of proteins with a novel cysteine-rich signature. |journal=Protein Sci. |volume=8 |issue= 7 |pages= 1557–61 |year= 1999 |pmid= 10422847 |doi=
*cite journal | author=Wang X, Stollar BD |title=Immunoglobulin VH gene expression in human aging. |journal=Clin. Immunol. |volume=93 |issue= 2 |pages= 132–42 |year= 1999 |pmid= 10527689 |doi= 10.1006/clim.1999.4781
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Simpson JC, Wellenreuther R, Poustka A, "et al." |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058
*cite journal | author=Chen D, Li X, Zhai Z, Shu HB |title=A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15985–91 |year= 2002 |pmid= 11854271 |doi= 10.1074/jbc.M108675200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hillier LW, Fulton RS, Fulton LA, "et al." |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Chuang TH, Ulevitch RJ |title=Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors. |journal=Nat. Immunol. |volume=5 |issue= 5 |pages= 495–502 |year= 2004 |pmid= 15107846 |doi= 10.1038/ni1066
*cite journal | author=Feng F, Davis A, Lake JA, "et al." |title=Ring finger protein ZIN interacts with human immunodeficiency virus type 1 Vif. |journal=J. Virol. |volume=78 |issue= 19 |pages= 10574–81 |year= 2004 |pmid= 15367624 |doi= 10.1128/JVI.78.19.10574-10581.2004
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Wiemann S, Arlt D, Huber W, "et al." |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704
*cite journal | author=Oh JH, Yang JO, Hahn Y, "et al." |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2
*cite journal | author=Mehrle A, Rosenfelder H, Schupp I, "et al." |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139
*cite journal | author=Fearns C, Pan Q, Mathison JC, Chuang TH |title=Triad3A regulates ubiquitination and proteasomal degradation of RIP1 following disruption of Hsp90 binding. |journal=J. Biol. Chem. |volume=281 |issue= 45 |pages= 34592–600 |year= 2006 |pmid= 16968706 |doi= 10.1074/jbc.M604019200

External links

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