SPAG9

Sperm associated antigen 9, also known as SPAG9, is a human gene.cite web | title = Entrez Gene: SPAG9 sperm associated antigen 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9043| accessdate = ]

PBB_Summary
section_title =
summary_text = Extracellular signals are transduced into cells through mitogen-activated protein kinases. The structural organization of these kinases into specific signaling domains is facilitated by scaffolding proteins involved in closely tethering different kinases so that successive phosphorylation events can occur. The protein encoded by this gene is a scaffolding protein that brings together mitogen-activated protein kinases and their transcription factor targets for the activation of specific signaling pathways. This gene which is abundantly expressed in testicular haploid germ cells encodes a protein that is recognized by sperm-agglutinating antibodies and implicated in infertility.cite web | title = Entrez Gene: SPAG9 sperm associated antigen 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9043| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ichijo H |title=From receptors to stress-activated MAP kinases. |journal=Oncogene |volume=18 |issue= 45 |pages= 6087–93 |year= 1999 |pmid= 10557099 |doi= 10.1038/sj.onc.1203129
*cite journal | author=Nakajima D, Okazaki N, Yamakawa H, "et al." |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=
*cite journal | author=Shankar S, Mohapatra B, Suri A |title=Cloning of a novel human testis mRNA specifically expressed in testicular haploid germ cells, having unique palindromic sequences and encoding a leucine zipper dimerization motif. |journal=Biochem. Biophys. Res. Commun. |volume=243 |issue= 2 |pages= 561–5 |year= 1998 |pmid= 9480848 |doi= 10.1006/bbrc.1997.7943
*cite journal | author=Nagase T, Ishikawa K, Miyajima N, "et al." |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 1 |pages= 31–9 |year= 1998 |pmid= 9628581 |doi=
*cite journal | author=Lee CM, Onésime D, Reddy CD, "et al." |title=JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 22 |pages= 14189–94 |year= 2002 |pmid= 12391307 |doi= 10.1073/pnas.232310199
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Yasuoka H, Ihn H, Medsger TA, "et al." |title=A novel protein highly expressed in testis is overexpressed in systemic sclerosis fibroblasts and targeted by autoantibodies. |journal=J. Immunol. |volume=171 |issue= 12 |pages= 6883–90 |year= 2004 |pmid= 14662895 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Bouwmeester T, Bauch A, Ruffner H, "et al." |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086
*cite journal | author=Brill LM, Salomon AR, Ficarro SB, "et al." |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763–72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Jagadish N, Rana R, Selvi R, "et al." |title=Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein. |journal=Biochem. J. |volume=389 |issue= Pt 1 |pages= 73–82 |year= 2005 |pmid= 15693750 |doi= 10.1042/BJ20041577
*cite journal | author=Jagadish N, Rana R, Mishra D, "et al." |title=Sperm associated antigen 9 (SPAG9): a new member of c-Jun NH2 -terminal kinase (JNK) interacting protein exclusively expressed in testis. |journal=The Keio journal of medicine |volume=54 |issue= 2 |pages= 66–71 |year= 2005 |pmid= 16077255 |doi=
*cite journal | author=Guinn BA, Bland EA, Lodi U, "et al." |title=Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia. |journal=Biochem. Biophys. Res. Commun. |volume=335 |issue= 4 |pages= 1293–304 |year= 2005 |pmid= 16112646 |doi= 10.1016/j.bbrc.2005.08.024
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Rana R, Jagadish N, Garg M, "et al." |title=Small interference RNA-mediated knockdown of sperm associated antigen 9 having structural homology with c-Jun N-terminal kinase-interacting protein. |journal=Biochem. Biophys. Res. Commun. |volume=340 |issue= 1 |pages= 158–64 |year= 2006 |pmid= 16356479 |doi= 10.1016/j.bbrc.2005.11.168
*cite journal | author=Rana R, Jagadish N, Garg M, "et al." |title=Immunogenicity study of recombinant human sperm-associated antigen 9 in bonnet macaque (Macaca radiata). |journal=Hum. Reprod. |volume=21 |issue= 11 |pages= 2894–900 |year= 2007 |pmid= 16959808 |doi= 10.1093/humrep/del068

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