BCCIP

BRCA2 and CDKN1A interacting protein, also known as BCCIP, is a human gene.cite web | title = Entrez Gene: BCCIP BRCA2 and CDKN1A interacting protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56647| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. Several transcript variants encoding different isoforms have been described for this gene.cite web | title = Entrez Gene: BCCIP BRCA2 and CDKN1A interacting protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56647| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Coleman RA, Rao P, Fogelsong RJ, Bardes ES |title=2-Bromopalmitoyl-CoA and 2-bromopalmitate: promiscuous inhibitors of membrane-bound enzymes. |journal=Biochim. Biophys. Acta |volume=1125 |issue= 2 |pages= 203–9 |year= 1992 |pmid= 1571364 |doi=
*cite journal | author=Ono T, Kitaura H, Ugai H, "et al." |title=TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase. |journal=J. Biol. Chem. |volume=275 |issue= 40 |pages= 31145–54 |year= 2000 |pmid= 10878006 |doi= 10.1074/jbc.M003031200
*cite journal | author=Liu J, Yuan Y, Huan J, Shen Z |title=Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2. |journal=Oncogene |volume=20 |issue= 3 |pages= 336–45 |year= 2001 |pmid= 11313963 |doi= 10.1038/sj.onc.1204098
*cite journal | author=Machackova E, Damborsky J, Valik D, Foretova L |title=Novel germline BRCA1 and BRCA2 mutations in breast and breast/ovarian cancer families from the Czech Republic. |journal=Hum. Mutat. |volume=18 |issue= 6 |pages= 545 |year= 2002 |pmid= 11748848 |doi= 10.1002/humu.1232
*cite journal | author=Armakolas A, Ladopoulou A, Konstantopoulou I, "et al." |title=BRCA2 gene mutations in Greek patients with familial breast cancer. |journal=Hum. Mutat. |volume=19 |issue= 1 |pages= 81–2 |year= 2002 |pmid= 11754111 |doi= 10.1002/humu.9003
*cite journal | author=Robson M, Scheuer L, Nafa K, "et al." |title=Unique de novo mutation of BRCA2 in a woman with early onset breast cancer. |journal=J. Med. Genet. |volume=39 |issue= 2 |pages= 126–8 |year= 2002 |pmid= 11836363 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Meng X, Liu J, Shen Z |title=Genomic structure of the human BCCIP gene and its expression in cancer. |journal=Gene |volume=302 |issue= 1-2 |pages= 139–46 |year= 2003 |pmid= 12527204 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Meng X, Liu J, Shen Z |title=Inhibition of G1 to S cell cycle progression by BCCIP beta. |journal=Cell Cycle |volume=3 |issue= 3 |pages= 343–8 |year= 2004 |pmid= 14726710 |doi=
*cite journal | author=Deloukas P, Earthrowl ME, Grafham DV, "et al." |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462
*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Meng X, Lu H, Shen Z |title=BCCIP functions through p53 to regulate the expression of p21Waf1/Cip1. |journal=Cell Cycle |volume=3 |issue= 11 |pages= 1457–62 |year= 2007 |pmid= 15539944 |doi=
*cite journal | author=Lu H, Guo X, Meng X, "et al." |title=The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair. |journal=Mol. Cell. Biol. |volume=25 |issue= 5 |pages= 1949–57 |year= 2005 |pmid= 15713648 |doi= 10.1128/MCB.25.5.1949-1957.2005
*cite journal | author=Stelzl U, Worm U, Lalowski M, "et al." |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=Meng X, Yue J, Liu Z, Shen Z |title=Abrogation of the transactivation activity of p53 by BCCIP down-regulation. |journal=J. Biol. Chem. |volume=282 |issue= 3 |pages= 1570–6 |year= 2007 |pmid= 17135243 |doi= 10.1074/jbc.M607520200
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134

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