- MED4
"MED4" also known as "mediator complex subunit 4" is a human
gene .cite web | title = Entrez Gene: MED4 mediator of RNA polymerase II transcription, subunit 4 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29079| accessdate = ] cite journal | author = Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Näär AM, Erdjument-Bromage H, Tempst P, Freedman LP | title = Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex | journal = Nature | volume = 398 | issue = 6730 | pages = 824–8 | year = 1999 | month = April | pmid = 10235266 | doi = 10.1038/19783 | url = | issn = ] cite journal | author = Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z | title = Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells | journal = Genome research | volume = 10 | issue = 10 | pages = 1546–60 | year = 2000 | month = October | pmid = 11042152 | pmc = 310934 | doi = 10.1101/gr.140200 | url = | issn = ]Function
The
protein encoded by this gene is a component of thevitamin D receptor -interacting protein (DRIP) complex which functions as anuclear receptor coactivator. The DRIP complex is capable of activating nuclear receptors in a ligand-dependent manner.References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Conaway JW, Florens L, Sato S, "et al." |title=The mammalian Mediator complex. |journal=FEBS Lett. |volume=579 |issue= 4 |pages= 904–8 |year= 2005 |pmid= 15680972 |doi= 10.1016/j.febslet.2004.11.031
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Ito M, Yuan CX, Malik S, "et al." |title=Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. |journal=Mol. Cell |volume=3 |issue= 3 |pages= 361–70 |year= 1999 |pmid= 10198638 |doi=
*cite journal | author=Rachez C, Lemon BD, Suldan Z, "et al." |title=Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. |journal=Nature |volume=398 |issue= 6730 |pages= 824–8 |year= 1999 |pmid= 10235266 |doi= 10.1038/19783
*cite journal | author=Näär AM, Beaurang PA, Zhou S, "et al." |title=Composite co-activator ARC mediates chromatin-directed transcriptional activation. |journal=Nature |volume=398 |issue= 6730 |pages= 828–32 |year= 1999 |pmid= 10235267 |doi= 10.1038/19789
*cite journal | author=Malik S, Gu W, Wu W, "et al." |title=The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs. |journal=Mol. Cell |volume=5 |issue= 4 |pages= 753–60 |year= 2000 |pmid= 10882111 |doi=
*cite journal | author=Zhang QH, Ye M, Wu XY, "et al." |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=PBB_Controls
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