MTCP1

Mature T-cell proliferation 1, also known as MTCP1, is a human gene.cite web | title = Entrez Gene: MTCP1 mature T-cell proliferation 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4515| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene was identified by involvement in some t(X;14) translocations associated with mature T-cell proliferations. The gene has two ORFs that encode two different proteins. The upstream ORF encodes a 13kDa protein that is a member of the TCL1 family; this protein may be involved in leukemogenesis. The downstream ORF encodes an 8kDa protein that localizes to mitochondria. Alternative splicing results in multiple transcript variants.cite web | title = Entrez Gene: MTCP1 mature T-cell proliferation 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4515| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kenwrick S, Levinson B, Taylor S, "et al." |title=Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene. |journal=Hum. Mol. Genet. |volume=1 |issue= 3 |pages= 179–86 |year= 1993 |pmid= 1303175 |doi=
*cite journal | author=Madani A, Soulier J, Schmid M, "et al." |title=The 8 kD product of the putative oncogene MTCP-1 is a mitochondrial protein. |journal=Oncogene |volume=10 |issue= 11 |pages= 2259–62 |year= 1995 |pmid= 7784073 |doi=
*cite journal | author=Soulier J, Madani A, Cacheux V, "et al." |title=The MTCP-1/c6.1B gene encodes for a cytoplasmic 8 kD protein overexpressed in T cell leukemia bearing a t(X;14) translocation. |journal=Oncogene |volume=9 |issue= 12 |pages= 3565–70 |year= 1994 |pmid= 7970717 |doi=
*cite journal | author=Thick J, Mak YF, Metcalfe J, "et al." |title=A gene on chromosome Xq28 associated with T-cell prolymphocytic leukemia in two patients with ataxia telangiectasia. |journal=Leukemia |volume=8 |issue= 4 |pages= 564–73 |year= 1994 |pmid= 8152252 |doi=
*cite journal | author=Fisch P, Forster A, Sherrington PD, "et al." |title=The chromosomal translocation t(X;14)(q28;q11) in T-cell pro-lymphocytic leukaemia breaks within one gene and activates another. |journal=Oncogene |volume=8 |issue= 12 |pages= 3271–6 |year= 1993 |pmid= 8247530 |doi=
*cite journal | author=Stern MH, Soulier J, Rosenzwajg M, "et al." |title=MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha/delta locus in mature T cell proliferations. |journal=Oncogene |volume=8 |issue= 9 |pages= 2475–83 |year= 1993 |pmid= 8361760 |doi=
*cite journal | author=Madani A, Choukroun V, Soulier J, "et al." |title=Expression of p13MTCP1 is restricted to mature T-cell proliferations with t(X;14) translocations. |journal=Blood |volume=87 |issue= 5 |pages= 1923–7 |year= 1996 |pmid= 8634440 |doi=
*cite journal | author=Gritti C, Choukroun V, Soulier J, "et al." |title=Alternative origin of p13MTCP1-encoding transcripts in mature T-cell proliferations with t(X;14) translocations. |journal=Oncogene |volume=15 |issue= 11 |pages= 1329–35 |year= 1997 |pmid= 9315101 |doi= 10.1038/sj.onc.1201303
*cite journal | author=Barthe P, Yang YS, Chiche L, "et al." |title=Solution structure of human p8MTCP1, a cysteine-rich protein encoded by the MTCP1 oncogene, reveals a new alpha-helical assembly motif. |journal=J. Mol. Biol. |volume=274 |issue= 5 |pages= 801–15 |year= 1998 |pmid= 9405159 |doi= 10.1006/jmbi.1997.1438
*cite journal | author=Du Bois GC, Song SP, Kulikovskaya I, "et al." |title=Purification and characterization of recombinant forms of TCL-1 and MTCP-1 proteins. |journal=Protein Expr. Purif. |volume=12 |issue= 2 |pages= 215–25 |year= 1998 |pmid= 9518463 |doi= 10.1006/prep.1997.0822
*cite journal | author=Fu ZQ, Du Bois GC, Song SP, "et al." |title=Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 7 |pages= 3413–8 |year= 1998 |pmid= 9520380 |doi=
*cite journal | author=Yang YS, Guignard L, Padilla A, "et al." |title=Solution structure of the recombinant human oncoprotein p13MTCP1. |journal=J. Biomol. NMR |volume=11 |issue= 3 |pages= 337–54 |year= 1998 |pmid= 9691281 |doi=
*cite journal | author=Guignard L, Padilla A, Mispelter J, "et al." |title=Backbone dynamics and solution structure refinement of the 15N-labeled human oncogenic protein p13MTCP1: comparison with X-ray data. |journal=J. Biomol. NMR |volume=17 |issue= 3 |pages= 215–30 |year= 2000 |pmid= 10959629 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Laine J, Künstle G, Obata T, Noguchi M |title=Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. |journal=J. Biol. Chem. |volume=277 |issue= 5 |pages= 3743–51 |year= 2002 |pmid= 11707444 |doi= 10.1074/jbc.M107069200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Wiemann S, Arlt D, Huber W, "et al." |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Mehrle A, Rosenfelder H, Schupp I, "et al." |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139

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