MAL (gene)

Mal, T-cell differentiation protein, also known as MAL, is a human gene.cite web | title = Entrez Gene: MAL mal, T-cell differentiation protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4118| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3.cite web | title = Entrez Gene: MAL mal, T-cell differentiation protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4118| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Frank M |title=MAL, a proteolipid in glycosphingolipid enriched domains: functional implications in myelin and beyond. |journal=Prog. Neurobiol. |volume=60 |issue= 6 |pages= 531–44 |year= 2000 |pmid= 10739088 |doi=
*cite journal | author=Alonso MA, Barton DE, Francke U |title=Assignment of the T-cell differentiation gene MAL to human chromosome 2, region cen----q13. |journal=Immunogenetics |volume=27 |issue= 2 |pages= 91–5 |year= 1988 |pmid= 3257199 |doi=
*cite journal | author=Alonso MA, Weissman SM |title=cDNA cloning and sequence of MAL, a hydrophobic protein associated with human T-cell differentiation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 7 |pages= 1997–2001 |year= 1987 |pmid= 3494249 |doi=
*cite journal | author=Rancaño C, Rubio T, Alonso MA |title=Alternative splicing of human T-cell-specific MAL mRNA and its correlation with the exon/intron organization of the gene. |journal=Genomics |volume=21 |issue= 2 |pages= 447–50 |year= 1994 |pmid= 8088843 |doi= 10.1006/geno.1994.1294
*cite journal | author=Rancaño C, Rubio T, Correas I, Alonso MA |title=Genomic structure and subcellular localization of MAL, a human T-cell-specific proteolipid protein. |journal=J. Biol. Chem. |volume=269 |issue= 11 |pages= 8159–64 |year= 1994 |pmid= 8132541 |doi=
*cite journal | author=Millán J, Puertollano R, Fan L, "et al." |title=The MAL proteolipid is a component of the detergent-insoluble membrane subdomains of human T-lymphocytes. |journal=Biochem. J. |volume=321 ( Pt 1) |issue= |pages= 247–52 |year= 1997 |pmid= 9003426 |doi=
*cite journal | author=Millán J, Puertollano R, Fan L, Alonso MA |title=Caveolin and MAL, two protein components of internal detergent-insoluble membranes, are in distinct lipid microenvironments in MDCK cells. |journal=Biochem. Biophys. Res. Commun. |volume=233 |issue= 3 |pages= 707–12 |year= 1997 |pmid= 9168919 |doi= 10.1006/bbrc.1997.6530
*cite journal | author=Martín-Belmonte F, Kremer L, Albar JP, "et al." |title=Expression of the MAL gene in the thyroid: the MAL proteolipid, a component of glycolipid-enriched membranes, is apically distributed in thyroid follicles. |journal=Endocrinology |volume=139 |issue= 4 |pages= 2077–84 |year= 1998 |pmid= 9528996 |doi=
*cite journal | author=Köhler C, Håkansson A, Svanborg C, "et al." |title=Protease activation in apoptosis induced by MAL. |journal=Exp. Cell Res. |volume=249 |issue= 2 |pages= 260–8 |year= 1999 |pmid= 10366425 |doi= 10.1006/excr.1999.4472
*cite journal | author=Frank M, Schaeren-Wiemers N, Schneider R, Schwab ME |title=Developmental expression pattern of the myelin proteolipid MAL indicates different functions of MAL for immature Schwann cells and in a late step of CNS myelinogenesis. |journal=J. Neurochem. |volume=73 |issue= 2 |pages= 587–97 |year= 1999 |pmid= 10428054 |doi=
*cite journal | author=Puertollano R, Alonso MA |title=MAL, an integral element of the apical sorting machinery, is an itinerant protein that cycles between the trans-Golgi network and the plasma membrane. |journal=Mol. Biol. Cell |volume=10 |issue= 10 |pages= 3435–47 |year= 1999 |pmid= 10512878 |doi=
*cite journal | author=Erne B, Sansano S, Frank M, Schaeren-Wiemers N |title=Rafts in adult peripheral nerve myelin contain major structural myelin proteins and myelin and lymphocyte protein (MAL) and CD59 as specific markers. |journal=J. Neurochem. |volume=82 |issue= 3 |pages= 550–62 |year= 2002 |pmid= 12153479 |doi=
*cite journal | author=Copie-Bergman C, Plonquet A, Alonso MA, "et al." |title=MAL expression in lymphoid cells: further evidence for MAL as a distinct molecular marker of primary mediastinal large B-cell lymphomas. |journal=Mod. Pathol. |volume=15 |issue= 11 |pages= 1172–80 |year= 2003 |pmid= 12429796 |doi= 10.1097/01.MP.0000032534.81894.B3
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kazemi-Noureini S, Colonna-Romano S, Ziaee AA, "et al." |title=Differential gene expression between squamous cell carcinoma of esophageus and its normal epithelium; altered pattern of mal, akr1c2, and rab11a expression. |journal=World J. Gastroenterol. |volume=10 |issue= 12 |pages= 1716–21 |year= 2004 |pmid= 15188492 |doi=
*cite journal | author=Llorente A, de Marco MC, Alonso MA |title=Caveolin-1 and MAL are located on prostasomes secreted by the prostate cancer PC-3 cell line. |journal=J. Cell. Sci. |volume=117 |issue= Pt 22 |pages= 5343–51 |year= 2005 |pmid= 15466889 |doi= 10.1242/jcs.01420
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Dukhovny A, Goldstein Magal L, Hirschberg K |title=The MAL proteolipid restricts detergent-mediated membrane pore expansion and percolation. |journal=Mol. Membr. Biol. |volume=23 |issue= 3 |pages= 245–57 |year= 2006 |pmid= 16785208 |doi= 10.1080/09687860600601445
*cite journal | author=Mimori K, Nishida K, Nakamura Y, "et al." |title=Loss of MAL expression in precancerous lesions of the esophagus. |journal=Ann. Surg. Oncol. |volume=14 |issue= 5 |pages= 1670–7 |year= 2007 |pmid= 17151798 |doi= 10.1245/s10434-006-9064-2

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