LGALS9

Lectin, galactoside-binding, soluble, 9 (galectin 9), also known as LGALS9, is a human gene.cite web | title = Entrez Gene: LGALS9 lectin, galactoside-binding, soluble, 9 (galectin 9)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3965| accessdate = ]

PBB_Summary
section_title =
summary_text = The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. This galectin is strongly overexpressed in Hodgkin's disease tissue and it might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its consistently associated immunodeficiency. The protein has N- and C- terminal carbohydrate-binding domains connected by a link peptide. Multiple alternatively spliced transcript variants have been found for this gene.cite web | title = Entrez Gene: LGALS9 lectin, galactoside-binding, soluble, 9 (galectin 9)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3965| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hirashima M, Kashio Y, Nishi N, "et al." |title=Galectin-9 in physiological and pathological conditions. |journal=Glycoconj. J. |volume=19 |issue= 7-9 |pages= 593–600 |year= 2004 |pmid= 14758084 |doi= 10.1023/B:GLYC.0000014090.63206.2f
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Türeci O, Schmitt H, Fadle N, "et al." |title=Molecular definition of a novel human galectin which is immunogenic in patients with Hodgkin's disease. |journal=J. Biol. Chem. |volume=272 |issue= 10 |pages= 6416–22 |year= 1997 |pmid= 9045665 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Matsumoto R, Matsumoto H, Seki M, "et al." |title=Human ecalectin, a variant of human galectin-9, is a novel eosinophil chemoattractant produced by T lymphocytes. |journal=J. Biol. Chem. |volume=273 |issue= 27 |pages= 16976–84 |year= 1998 |pmid= 9642261 |doi=
*cite journal | author=Matsumoto R, Hirashima M, Kita H, Gleich GJ |title=Biological activities of ecalectin: a novel eosinophil-activating factor. |journal=J. Immunol. |volume=168 |issue= 4 |pages= 1961–7 |year= 2002 |pmid= 11823532 |doi=
*cite journal | author=Kageshita T, Kashio Y, Yamauchi A, "et al." |title=Possible role of galectin-9 in cell aggregation and apoptosis of human melanoma cell lines and its clinical significance. |journal=Int. J. Cancer |volume=99 |issue= 6 |pages= 809–16 |year= 2002 |pmid= 12115481 |doi= 10.1002/ijc.10436
*cite journal | author=Imaizumi T, Kumagai M, Sasaki N, "et al." |title=Interferon-gamma stimulates the expression of galectin-9 in cultured human endothelial cells. |journal=J. Leukoc. Biol. |volume=72 |issue= 3 |pages= 486–91 |year= 2002 |pmid= 12223516 |doi=
*cite journal | author=Asakura H, Kashio Y, Nakamura K, "et al." |title=Selective eosinophil adhesion to fibroblast via IFN-gamma-induced galectin-9. |journal=J. Immunol. |volume=169 |issue= 10 |pages= 5912–8 |year= 2003 |pmid= 12421975 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kashio Y, Nakamura K, Abedin MJ, "et al." |title=Galectin-9 induces apoptosis through the calcium-calpain-caspase-1 pathway. |journal=J. Immunol. |volume=170 |issue= 7 |pages= 3631–6 |year= 2003 |pmid= 12646627 |doi=
*cite journal | author=Abedin MJ, Kashio Y, Seki M, "et al." |title=Potential roles of galectins in myeloid differentiation into three different lineages. |journal=J. Leukoc. Biol. |volume=73 |issue= 5 |pages= 650–6 |year= 2003 |pmid= 12714580 |doi=
*cite journal | author=Matsuda A, Suzuki Y, Honda G, "et al." |title=Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. |journal=Oncogene |volume=22 |issue= 21 |pages= 3307–18 |year= 2003 |pmid= 12761501 |doi= 10.1038/sj.onc.1206406
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Irie A, Yamauchi A, Kontani K, "et al." |title=Galectin-9 as a prognostic factor with antimetastatic potential in breast cancer. |journal=Clin. Cancer Res. |volume=11 |issue= 8 |pages= 2962–8 |year= 2005 |pmid= 15837748 |doi= 10.1158/1078-0432.CCR-04-0861
*cite journal | author=Kasamatsu A, Uzawa K, Nakashima D, "et al." |title=Galectin-9 as a regulator of cellular adhesion in human oral squamous cell carcinoma cell lines. |journal=Int. J. Mol. Med. |volume=16 |issue= 2 |pages= 269–73 |year= 2005 |pmid= 16012760 |doi=
*cite journal | author=Dai SY, Nakagawa R, Itoh A, "et al." |title=Galectin-9 induces maturation of human monocyte-derived dendritic cells. |journal=J. Immunol. |volume=175 |issue= 5 |pages= 2974–81 |year= 2005 |pmid= 16116184 |doi=
*cite journal | author=Zhu C, Anderson AC, Schubart A, "et al." |title=The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. |journal=Nat. Immunol. |volume=6 |issue= 12 |pages= 1245–52 |year= 2006 |pmid= 16286920 |doi= 10.1038/ni1271
*cite journal | author=van de Weyer PS, Muehlfeit M, Klose C, "et al." |title=A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9. |journal=Biochem. Biophys. Res. Commun. |volume=351 |issue= 2 |pages= 571–6 |year= 2007 |pmid= 17069754 |doi= 10.1016/j.bbrc.2006.10.079

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