ARHGEF12

Rho guanine nucleotide exchange factor (GEF) 12, also known as ARHGEF12, is a human gene.cite web | title = Entrez Gene: ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23365| accessdate = ]

PBB_Summary
section_title =
summary_text = Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein is observed to form myeloid/lymphoid fusion partner in acute myeloid leukemia.cite web | title = Entrez Gene: ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23365| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nagase T, Ishikawa K, Nakajima D, "et al." |title=Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=4 |issue= 2 |pages= 141–50 |year= 1997 |pmid= 9205841 |doi=
*cite journal | author=Kourlas PJ, Strout MP, Becknell B, "et al." |title=Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 5 |pages= 2145–50 |year= 2000 |pmid= 10681437 |doi= 10.1073/pnas.040569197
*cite journal | author=Fukuhara S, Chikumi H, Gutkind JS |title=Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho. |journal=FEBS Lett. |volume=485 |issue= 2-3 |pages= 183–8 |year= 2000 |pmid= 11094164 |doi=
*cite journal | author=Reuther GW, Lambert QT, Booden MA, "et al." |title=Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA. |journal=J. Biol. Chem. |volume=276 |issue= 29 |pages= 27145–51 |year= 2001 |pmid= 11373293 |doi= 10.1074/jbc.M103565200
*cite journal | author=Taya S, Inagaki N, Sengiku H, "et al." |title=Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF. |journal=J. Cell Biol. |volume=155 |issue= 5 |pages= 809–20 |year= 2002 |pmid= 11724822 |doi= 10.1083/jcb.200106139
*cite journal | author=Chikumi H, Fukuhara S, Gutkind JS |title=Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase. |journal=J. Biol. Chem. |volume=277 |issue= 14 |pages= 12463–73 |year= 2002 |pmid= 11799111 |doi= 10.1074/jbc.M108504200
*cite journal | author=Perrot V, Vazquez-Prado J, Gutkind JS |title=Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 43115–20 |year= 2003 |pmid= 12183458 |doi= 10.1074/jbc.M206005200
*cite journal | author=Aurandt J, Vikis HG, Gutkind JS, "et al." |title=The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 19 |pages= 12085–90 |year= 2002 |pmid= 12196628 |doi= 10.1073/pnas.142433199
*cite journal | author=Hirotani M, Ohoka Y, Yamamoto T, "et al." |title=Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors. |journal=Biochem. Biophys. Res. Commun. |volume=297 |issue= 1 |pages= 32–7 |year= 2002 |pmid= 12220504 |doi=
*cite journal | author=Driessens MH, Olivo C, Nagata K, "et al." |title=B plexins activate Rho through PDZ-RhoGEF. |journal=FEBS Lett. |volume=529 |issue= 2-3 |pages= 168–72 |year= 2002 |pmid= 12372594 |doi=
*cite journal | author=Wennerberg K, Ellerbroek SM, Liu RY, "et al." |title=RhoG signals in parallel with Rac1 and Cdc42. |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47810–7 |year= 2003 |pmid= 12376551 |doi= 10.1074/jbc.M203816200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Suzuki N, Nakamura S, Mano H, Kozasa T |title=Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 2 |pages= 733–8 |year= 2003 |pmid= 12515866 |doi= 10.1073/pnas.0234057100
*cite journal | author=Chikumi H, Barac A, Behbahani B, "et al." |title=Homo- and hetero-oligomerization of PDZ-RhoGEF, LARG and p115RhoGEF by their C-terminal region regulates their in vivo Rho GEF activity and transforming potential. |journal=Oncogene |volume=23 |issue= 1 |pages= 233–40 |year= 2004 |pmid= 14712228 |doi= 10.1038/sj.onc.1207012
*cite journal | author=Wang Q, Liu M, Kozasa T, "et al." |title=Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells. |journal=J. Biol. Chem. |volume=279 |issue= 28 |pages= 28831–4 |year= 2004 |pmid= 15143072 |doi= 10.1074/jbc.C400105200
*cite journal | author=Kristelly R, Gao G, Tesmer JJ |title=Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor. |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 47352–62 |year= 2004 |pmid= 15331592 |doi= 10.1074/jbc.M406056200
*cite journal | author=Ballif BA, Villén J, Beausoleil SA, "et al." |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell Proteomics |volume=3 |issue= 11 |pages= 1093–101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200
*cite journal | author=Okuhira K, Fitzgerald ML, Sarracino DA, "et al." |title=Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux. |journal=J. Biol. Chem. |volume=280 |issue= 47 |pages= 39653–64 |year= 2006 |pmid= 16192269 |doi= 10.1074/jbc.M510187200
*cite journal | author=Goto M, Muramatsu H, Mihara H, "et al." |title=Crystal structures of Delta1-piperideine-2-carboxylate/Delta1-pyrroline-2-carboxylate reductase belonging to a new family of NAD(P)H-dependent oxidoreductases: conformational change, substrate recognition, and stereochemistry of the reaction. |journal=J. Biol. Chem. |volume=280 |issue= 49 |pages= 40875–84 |year= 2006 |pmid= 16192274 |doi= 10.1074/jbc.M507399200
*cite journal | author=Bourguignon LY, Gilad E, Brightman A, "et al." |title=Hyaluronan-CD44 interaction with leukemia-associated RhoGEF and epidermal growth factor receptor promotes Rho/Ras co-activation, phospholipase C epsilon-Ca2+ signaling, and cytoskeleton modification in head and neck squamous cell carcinoma cells. |journal=J. Biol. Chem. |volume=281 |issue= 20 |pages= 14026–40 |year= 2006 |pmid= 16565089 |doi= 10.1074/jbc.M507734200

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