GNRH2

Gonadotropin-releasing hormone 2, also known as GNRH2, is a human gene.cite web | title = Entrez Gene: GNRH2 gonadotropin-releasing hormone 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2797| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a preproprotein that is cleaved to form a secreted 10 aa peptide hormone. The secreted decapeptide regulates reproduction in females by stimulating the secretion of both luteinizing- and follicle-stimulating hormones. Three transcript variants that encode unique proproteins but the same peptide hormone have been found for this gene.cite web | title = Entrez Gene: GNRH2 gonadotropin-releasing hormone 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2797| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Neill JD |title=GnRH and GnRH receptor genes in the human genome. |journal=Endocrinology |volume=143 |issue= 3 |pages= 737–43 |year= 2002 |pmid= 11861490 |doi=
*cite journal | author=Leung PC, Cheng CK, Zhu XM |title=Multi-factorial role of GnRH-I and GnRH-II in the human ovary. |journal=Mol. Cell. Endocrinol. |volume=202 |issue= 1-2 |pages= 145–53 |year= 2004 |pmid= 12770744 |doi=
*cite journal | author=Limonta P, Moretti RM, Marelli MM, Motta M |title=The biology of gonadotropin hormone-releasing hormone: role in the control of tumor growth and progression in humans. |journal=Frontiers in neuroendocrinology |volume=24 |issue= 4 |pages= 279–95 |year= 2004 |pmid= 14726258 |doi=
*cite journal | author=Bloch B, Gaillard RC, Culler MD, Negro-Vilar A |title=Immunohistochemical detection of proluteinizing hormone-releasing hormone peptides in neurons in the human hypothalamus. |journal=J. Clin. Endocrinol. Metab. |volume=74 |issue= 1 |pages= 135–8 |year= 1992 |pmid= 1727812 |doi=
*cite journal | author=White RB, Eisen JA, Kasten TL, Fernald RD |title=Second gene for gonadotropin-releasing hormone in humans. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 1 |pages= 305–9 |year= 1998 |pmid= 9419371 |doi=
*cite journal | author=Chen A, Laskar-Levy O, Ben-Aroya N, Koch Y |title=Transcriptional regulation of the human GnRH II gene is mediated by a putative cAMP response element. |journal=Endocrinology |volume=142 |issue= 8 |pages= 3483–92 |year= 2001 |pmid= 11459794 |doi=
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Gründker C, Günthert AR, Millar RP, Emons G |title=Expression of gonadotropin-releasing hormone II (GnRH-II) receptor in human endometrial and ovarian cancer cells and effects of GnRH-II on tumor cell proliferation. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 3 |pages= 1427–30 |year= 2002 |pmid= 11889221 |doi=
*cite journal | author=Chen A, Zi K, Laskar-Levy O, Koch Y |title=The transcription of the hGnRH-I and hGnRH-II genes in human neuronal cells is differentially regulated by estrogen. |journal=J. Mol. Neurosci. |volume=18 |issue= 1-2 |pages= 67–76 |year= 2002 |pmid= 11931351 |doi=
*cite journal | author=Chen A, Ganor Y, Rahimipour S, "et al." |title=The neuropeptides GnRH-II and GnRH-I are produced by human T cells and trigger laminin receptor gene expression, adhesion, chemotaxis and homing to specific organs. |journal=Nat. Med. |volume=8 |issue= 12 |pages= 1421–6 |year= 2003 |pmid= 12447356 |doi= 10.1038/nm801
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Cheng CK, Hoo RL, Chow BK, Leung PC |title=Functional cooperation between multiple regulatory elements in the untranslated exon 1 stimulates the basal transcription of the human GnRH-II gene. |journal=Mol. Endocrinol. |volume=17 |issue= 7 |pages= 1175–91 |year= 2004 |pmid= 12663744 |doi= 10.1210/me.2002-0418
*cite journal | author=Islami D, Bischof P, Chardonnens D |title=Possible interactions between leptin, gonadotrophin-releasing hormone (GnRH-I and II) and human chorionic gonadotrophin (hCG). |journal=Eur. J. Obstet. Gynecol. Reprod. Biol. |volume=110 |issue= 2 |pages= 169–75 |year= 2004 |pmid= 12969578 |doi=
*cite journal | author=Chou CS, Beristain AG, MacCalman CD, Leung PC |title=Cellular localization of gonadotropin-releasing hormone (GnRH) I and GnRH II in first-trimester human placenta and decidua. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 3 |pages= 1459–66 |year= 2004 |pmid= 15001648 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=An BS, Choi JH, Choi KC, Leung PC |title=Differential role of progesterone receptor isoforms in the transcriptional regulation of human gonadotropin-releasing hormone I (GnRH I) receptor, GnRH I, and GnRH II. |journal=J. Clin. Endocrinol. Metab. |volume=90 |issue= 2 |pages= 1106–13 |year= 2005 |pmid= 15562029 |doi= 10.1210/jc.2004-0318
*cite journal | author=Tanriverdi F, Gonzalez-Martinez D, Silveira LF, "et al." |title=Expression of gonadotropin-releasing hormone type-I (GnRH-I) and type-II (GnRH-II) in human peripheral blood mononuclear cells (PMBCs) and regulation of B-lymphoblastoid cell proliferation by GnRH-I and GnRH-II. |journal=Exp. Clin. Endocrinol. Diabetes |volume=112 |issue= 10 |pages= 587–94 |year= 2005 |pmid= 15578334 |doi= 10.1055/s-2004-830404

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