SOST

SOST

Sclerostin, also known as SOST, is a human gene.cite web | title = Entrez Gene: SOST sclerosteosis| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50964| accessdate = ]

PBB_Summary
section_title =
summary_text = Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.cite web | title = Entrez Gene: SOST sclerosteosis| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50964| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Balemans W, Van Hul W |title=Human genetics of SOST. |journal=Journal of musculoskeletal & neuronal interactions |volume=6 |issue= 4 |pages= 355–6 |year= 2007 |pmid= 17185822 |doi=
*cite journal | author=Brunkow ME, Gardner JC, Van Ness J, "et al." |title=Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. |journal=Am. J. Hum. Genet. |volume=68 |issue= 3 |pages= 577–89 |year= 2001 |pmid= 11179006 |doi=
*cite journal | author=Balemans W, Ebeling M, Patel N, "et al." |title=Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST). |journal=Hum. Mol. Genet. |volume=10 |issue= 5 |pages= 537–43 |year= 2001 |pmid= 11181578 |doi=
*cite journal | author=Balemans W, Patel N, Ebeling M, "et al." |title=Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease. |journal=J. Med. Genet. |volume=39 |issue= 2 |pages= 91–7 |year= 2002 |pmid= 11836356 |doi=
*cite journal | author=Staehling-Hampton K, Proll S, Paeper BW, "et al." |title=A 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population. |journal=Am. J. Med. Genet. |volume=110 |issue= 2 |pages= 144–52 |year= 2002 |pmid= 12116252 |doi= 10.1002/ajmg.10401
*cite journal | author=Balemans W, Foernzler D, Parsons C, "et al." |title=Lack of association between the SOST gene and bone mineral density in perimenopausal women: analysis of five polymorphisms. |journal=Bone |volume=31 |issue= 4 |pages= 515–9 |year= 2003 |pmid= 12398949 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Winkler DG, Sutherland MK, Geoghegan JC, "et al." |title=Osteocyte control of bone formation via sclerostin, a novel BMP antagonist. |journal=EMBO J. |volume=22 |issue= 23 |pages= 6267–76 |year= 2004 |pmid= 14633986 |doi= 10.1093/emboj/cdg599
*cite journal | author=Sevetson B, Taylor S, Pan Y |title=Cbfa1/RUNX2 directs specific expression of the sclerosteosis gene (SOST). |journal=J. Biol. Chem. |volume=279 |issue= 14 |pages= 13849–58 |year= 2004 |pmid= 14739291 |doi= 10.1074/jbc.M306249200
*cite journal | author=van Bezooijen RL, Roelen BA, Visser A, "et al." |title=Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist. |journal=J. Exp. Med. |volume=199 |issue= 6 |pages= 805–14 |year= 2004 |pmid= 15024046 |doi= 10.1084/jem.20031454
*cite journal | author=Winkler DG, Yu C, Geoghegan JC, "et al." |title=Noggin and sclerostin bone morphogenetic protein antagonists form a mutually inhibitory complex. |journal=J. Biol. Chem. |volume=279 |issue= 35 |pages= 36293–8 |year= 2004 |pmid= 15199066 |doi= 10.1074/jbc.M400521200
*cite journal | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504
*cite journal | author=Sutherland MK, Geoghegan JC, Yu C, "et al." |title=Sclerostin promotes the apoptosis of human osteoblastic cells: a novel regulation of bone formation. |journal=Bone |volume=35 |issue= 4 |pages= 828–35 |year= 2005 |pmid= 15454089 |doi= 10.1016/j.bone.2004.05.023
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Uitterlinden AG, Arp PP, Paeper BW, "et al." |title=Polymorphisms in the sclerosteosis/van Buchem disease gene (SOST) region are associated with bone-mineral density in elderly whites. |journal=Am. J. Hum. Genet. |volume=75 |issue= 6 |pages= 1032–45 |year= 2005 |pmid= 15514891 |doi= 10.1086/426458
*cite journal | author=Winkler DG, Sutherland MS, Ojala E, "et al." |title=Sclerostin inhibition of Wnt-3a-induced C3H10T1/2 cell differentiation is indirect and mediated by bone morphogenetic proteins. |journal=J. Biol. Chem. |volume=280 |issue= 4 |pages= 2498–502 |year= 2005 |pmid= 15545262 |doi= 10.1074/jbc.M400524200
*cite journal | author=Poole KE, van Bezooijen RL, Loveridge N, "et al." |title=Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation. |journal=FASEB J. |volume=19 |issue= 13 |pages= 1842–4 |year= 2006 |pmid= 16123173 |doi= 10.1096/fj.05-4221fje
*cite journal | author=Gardner JC, van Bezooijen RL, Mervis B, "et al." |title=Bone mineral density in sclerosteosis; affected individuals and gene carriers. |journal=J. Clin. Endocrinol. Metab. |volume=90 |issue= 12 |pages= 6392–5 |year= 2006 |pmid= 16189254 |doi= 10.1210/jc.2005-1235
*cite journal | author=Ellies DL, Viviano B, McCarthy J, "et al." |title=Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity. |journal=J. Bone Miner. Res. |volume=21 |issue= 11 |pages= 1738–49 |year= 2007 |pmid= 17002572 |doi= 10.1359/jbmr.060810

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