- ME2
Malic enzyme 2, NAD(+)-dependent, mitochondrial, also known as ME2, is a human
gene .cite web | title = Entrez Gene: ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4200| accessdate = ]PBB_Summary
section_title =
summary_text = This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene.cite web | title = Entrez Gene: ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4200| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Siebert G, Ritter H, Kömpf J |title=Mitochondrial malic enzyme (E.C.1.1.1.40) in human leukocytes: formal genetics and population genetics. |journal=Hum. Genet. |volume=51 |issue= 3 |pages= 319–22 |year= 1980 |pmid= 511162 |doi=
*cite journal | author=Saha N, Jeremiah SJ, Povey S |title=Further data on mitochondrial malic enzyme in man. |journal=Hum. Hered. |volume=28 |issue= 6 |pages= 421–5 |year= 1978 |pmid= 680703 |doi=
*cite journal | author=Loeber G, Infante AA, Maurer-Fogy I, "et al." |title=Human NAD(+)-dependent mitochondrial malic enzyme. cDNA cloning, primary structure, and expression in Escherichia coli. |journal=J. Biol. Chem. |volume=266 |issue= 5 |pages= 3016–21 |year= 1991 |pmid= 1993674 |doi=
*cite journal | author=Taroni F, Gellera C, Di Donato S |title=Evidence for two distinct mitochondrial malic enzymes in human skeletal muscle: purification and properties of the NAD(P)+-dependent enzyme. |journal=Biochim. Biophys. Acta |volume=916 |issue= 3 |pages= 446–54 |year= 1988 |pmid= 3689803 |doi=
*cite journal | author=Bukato G, Kochan Z, Swierczyński J |title=Different regulatory properties of the cytosolic and mitochondrial forms of malic enzyme isolated from human brain. |journal=Int. J. Biochem. Cell Biol. |volume=27 |issue= 10 |pages= 1003–8 |year= 1996 |pmid= 7496989 |doi=
*cite journal | author=Bukato G, Kochan Z, Swierczyński J |title=Purification and properties of cytosolic and mitochondrial malic enzyme isolated from human brain. |journal=Int. J. Biochem. Cell Biol. |volume=27 |issue= 1 |pages= 47–54 |year= 1995 |pmid= 7757881 |doi=
*cite journal | author=Xu Y, Bhargava G, Wu H, "et al." |title=Crystal structure of human mitochondrial NAD(P)(+)-dependent malic enzyme: a new class of oxidative decarboxylases. |journal= |volume=7 |issue= 8 |pages= 877–889 |year= |pmid= 10467136 |doi=
*cite journal | author=Xu Y, Bhargava G, Wu H, "et al." |title=Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme: a new class of oxidative decarboxylases. |journal=Structure |volume=7 |issue= 8 |pages= R877–89 |year= 1999 |pmid= 10477256 |doi=
*cite journal | author=Yang Z, Floyd DL, Loeber G, Tong L |title=Structure of a closed form of human malic enzyme and implications for catalytic mechanism. |journal=Nat. Struct. Biol. |volume=7 |issue= 3 |pages= 251–7 |year= 2000 |pmid= 10700286 |doi= 10.1038/73378
*cite journal | author=Yang Z, Batra R, Floyd DL, "et al." |title=Potent and competitive inhibition of malic enzymes by lanthanide ions. |journal=Biochem. Biophys. Res. Commun. |volume=274 |issue= 2 |pages= 440–4 |year= 2000 |pmid= 10913357 |doi= 10.1006/bbrc.2000.3163
*cite journal | author=Butta N, González-Manchón C, Arias-Salgado EG, "et al." |title=Cloning and functional characterization of the 5' flanking region of the human mitochondrial malic enzyme gene. Regulatory role of Sp1 and AP-2. |journal=Eur. J. Biochem. |volume=268 |issue= 10 |pages= 3017–27 |year= 2001 |pmid= 11358520 |doi=
*cite journal | author=Yanaihara N, Kohno T, Takakura S, "et al." |title=Physical and transcriptional map of a 311-kb segment of chromosome 18q21, a candidate lung tumor suppressor locus. |journal=Genomics |volume=72 |issue= 2 |pages= 169–79 |year= 2001 |pmid= 11401430 |doi= 10.1006/geno.2000.6454
*cite journal | author=Yang Z, Lanks CW, Tong L |title=Molecular mechanism for the regulation of human mitochondrial NAD(P)+-dependent malic enzyme by ATP and fumarate. |journal=Structure |volume=10 |issue= 7 |pages= 951–60 |year= 2002 |pmid= 12121650 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gevaert K, Goethals M, Martens L, "et al." |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810
*cite journal | author=Tao X, Yang Z, Tong L |title=Crystal structures of substrate complexes of malic enzyme and insights into the catalytic mechanism. |journal=Structure |volume=11 |issue= 9 |pages= 1141–50 |year= 2004 |pmid= 12962632 |doi=
*cite journal | author=Navarro-Lérida I, Martínez Moreno M, Roncal F, "et al." |title=Proteomic identification of brain proteins that interact with dynein light chain LC8. |journal=Proteomics |volume=4 |issue= 2 |pages= 339–46 |year= 2004 |pmid= 14760703 |doi= 10.1002/pmic.200300528
*cite journal | author=Greenberg DA, Cayanis E, Strug L, "et al." |title=Malic enzyme 2 may underlie susceptibility to adolescent-onset idiopathic generalized epilepsy. |journal=Am. J. Hum. Genet. |volume=76 |issue= 1 |pages= 139–46 |year= 2005 |pmid= 15532013 |doi= 10.1086/426735
*cite journal | author=Hung HC, Chien YC, Hsieh JY, "et al." |title=Functional roles of ATP-binding residues in the catalytic site of human mitochondrial NAD(P)+-dependent malic enzyme. |journal=Biochemistry |volume=44 |issue= 38 |pages= 12737–45 |year= 2005 |pmid= 16171388 |doi= 10.1021/bi050510b
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406PBB_Controls
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