Aspartate beta-hydroxylase, also known as ASPH, is a human gene.cite web | title = Entrez Gene: ASPH aspartate beta-hydroxylase| url =| accessdate = ]

section_title =
summary_text = This gene is thought to play an important role in calcium homeostasis. Alternative splicing of this gene results in five transcript variants which vary in protein translation, the coding of catalytic domains, and tissue expression. Variation among these transcripts impacts their functions which involve roles in the calcium storage and release process in the endoplasmic and sarcoplasmic reticulum as well as hydroxylation of aspartic acid and asparagine in epidermal growth factor-like domains of various proteins.cite web | title = Entrez Gene: ASPH aspartate beta-hydroxylase| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Hirota K, Semenza GL |title=Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases. |journal=Biochem. Biophys. Res. Commun. |volume=338 |issue= 1 |pages= 610–6 |year= 2005 |pmid= 16154531 |doi= 10.1016/j.bbrc.2005.08.193
*cite journal | author=Korioth F, Gieffers C, Frey J |title=Cloning and characterization of the human gene encoding aspartyl beta-hydroxylase. |journal=Gene |volume=150 |issue= 2 |pages= 395–9 |year= 1995 |pmid= 7821814 |doi=
*cite journal | author=Lavaissiere L, Jia S, Nishiyama M, "et al." |title=Overexpression of human aspartyl(asparaginyl)beta-hydroxylase in hepatocellular carcinoma and cholangiocarcinoma. |journal=J. Clin. Invest. |volume=98 |issue= 6 |pages= 1313–23 |year= 1996 |pmid= 8823296 |doi=
*cite journal | author=Zhang L, Kelley J, Schmeisser G, "et al." |title=Complex formation between junctin, triadin, calsequestrin, and the ryanodine receptor. Proteins of the cardiac junctional sarcoplasmic reticulum membrane. |journal=J. Biol. Chem. |volume=272 |issue= 37 |pages= 23389–97 |year= 1997 |pmid= 9287354 |doi=
*cite journal | author=Wetzel GT, Ding S, Chen F |title=Molecular cloning of junctin from human and developing rabbit heart. |journal=Mol. Genet. Metab. |volume=69 |issue= 3 |pages= 252–8 |year= 2000 |pmid= 10767180 |doi= 10.1006/mgme.2000.2966
*cite journal | author=Dinchuk JE, Henderson NL, Burn TC, "et al." |title=Aspartyl beta -hydroxylase (Asph) and an evolutionarily conserved isoform of Asph missing the catalytic domain share exons with junctin. |journal=J. Biol. Chem. |volume=275 |issue= 50 |pages= 39543–54 |year= 2001 |pmid= 10956665 |doi= 10.1074/jbc.M006753200
*cite journal | author=Lim KY, Hong CS, Kim DH |title=cDNA cloning and characterization of human cardiac junctin. |journal=Gene |volume=255 |issue= 1 |pages= 35–42 |year= 2000 |pmid= 10974562 |doi=
*cite journal | author=Treves S, Feriotto G, Moccagatta L, "et al." |title=Molecular cloning, expression, functional characterization, chromosomal localization, and gene structure of junctate, a novel integral calcium binding protein of sarco(endo)plasmic reticulum membrane. |journal=J. Biol. Chem. |volume=275 |issue= 50 |pages= 39555–68 |year= 2001 |pmid= 11007777 |doi= 10.1074/jbc.M005473200
*cite journal | author=Kirchhefer U, Neumann J, Baba HA, "et al." |title=Cardiac hypertrophy and impaired relaxation in transgenic mice overexpressing triadin 1. |journal=J. Biol. Chem. |volume=276 |issue= 6 |pages= 4142–9 |year= 2001 |pmid= 11069905 |doi= 10.1074/jbc.M006443200
*cite journal | author=Sepe PS, Lahousse SA, Gemelli B, "et al." |title=Role of the aspartyl-asparaginyl-beta-hydroxylase gene in neuroblastoma cell motility. |journal=Lab. Invest. |volume=82 |issue= 7 |pages= 881–91 |year= 2002 |pmid= 12118090 |doi=
*cite journal | author=Ho SP, Scully MS, Krauthauser CM, "et al." |title=Antisense oligonucleotides selectively regulate aspartyl beta-hydroxylase and its truncated protein isoform in vitro but distribute poorly into A549 tumors in vivo. |journal=J. Pharmacol. Exp. Ther. |volume=302 |issue= 2 |pages= 795–803 |year= 2002 |pmid= 12130746 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Maeda T, Sepe P, Lahousse S, "et al." |title=Antisense oligodeoxynucleotides directed against aspartyl (asparaginyl) beta-hydroxylase suppress migration of cholangiocarcinoma cells. |journal=J. Hepatol. |volume=38 |issue= 5 |pages= 615–22 |year= 2004 |pmid= 12713872 |doi=
*cite journal | author=Treves S, Franzini-Armstrong C, Moccagatta L, "et al." |title=Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion. |journal=J. Cell Biol. |volume=166 |issue= 4 |pages= 537–48 |year= 2004 |pmid= 15302852 |doi= 10.1083/jcb.200404079
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Xian ZH, Zhang SH, Cong WM, "et al." |title=Expression of aspartyl beta-hydroxylase and its clinicopathological significance in hepatocellular carcinoma. |journal=Mod. Pathol. |volume=19 |issue= 2 |pages= 280–6 |year= 2006 |pmid= 16341145 |doi= 10.1038/modpathol.3800530
*cite journal | author=de la Monte SM, Tamaki S, Cantarini MC, "et al." |title=Aspartyl-(asparaginyl)-beta-hydroxylase regulates hepatocellular carcinoma invasiveness. |journal=J. Hepatol. |volume=44 |issue= 5 |pages= 971–83 |year= 2006 |pmid= 16564107 |doi= 10.1016/j.jhep.2006.01.038
*cite journal | author=Feldmann G, Nattermann J, Nischalke HD, "et al." |title=Detection of human aspartyl (asparaginyl) beta-hydroxylase and homeobox B7 mRNA in brush cytology specimens from patients with bile duct cancer. |journal=Endoscopy |volume=38 |issue= 6 |pages= 604–9 |year= 2006 |pmid= 16673309 |doi= 10.1055/s-2006-925065
*cite journal | author=Gundogan F, Elwood G, Greco D, "et al." |title=Role of aspartyl-(asparaginyl) beta-hydroxylase in placental implantation: Relevance to early pregnancy loss. |journal=Hum. Pathol. |volume=38 |issue= 1 |pages= 50–9 |year= 2007 |pmid= 16949909 |doi= 10.1016/j.humpath.2006.06.005

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