FGF5

Fibroblast growth factor 5, also known as FGF5, is a human gene.cite web | title = Entrez Gene: FGF5 fibroblast growth factor 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2250| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified.cite web | title = Entrez Gene: FGF5 fibroblast growth factor 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2250| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Li K, Stewart DJ, Ward HJ |title=Technology evaluation: gene therapy (FGF-5), Vical. |journal=Curr. Opin. Mol. Ther. |volume=1 |issue= 2 |pages= 260–5 |year= 2001 |pmid= 11715949 |doi=
*cite journal | author=Werner S, Roth WK, Bates B, "et al." |title=Fibroblast growth factor 5 proto-oncogene is expressed in normal human fibroblasts and induced by serum growth factors. |journal=Oncogene |volume=6 |issue= 11 |pages= 2137–44 |year= 1991 |pmid= 1658709 |doi=
*cite journal | author=Haub O, Drucker B, Goldfarb M |title=Expression of the murine fibroblast growth factor 5 gene in the adult central nervous system. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 20 |pages= 8022–6 |year= 1990 |pmid= 1700424 |doi=
*cite journal | author=Bates B, Hardin J, Zhan X, "et al." |title=Biosynthesis of human fibroblast growth factor-5. |journal=Mol. Cell. Biol. |volume=11 |issue= 4 |pages= 1840–5 |year= 1991 |pmid= 2005884 |doi=
*cite journal | author=Nguyen C, Roux D, Mattei MG, "et al." |title=The FGF-related oncogenes hst and int.2, and the bcl.1 locus are contained within one megabase in band q13 of chromosome 11, while the fgf.5 oncogene maps to 4q21. |journal=Oncogene |volume=3 |issue= 6 |pages= 703–8 |year= 1994 |pmid= 2577873 |doi=
*cite journal | author=Zhan X, Bates B, Hu XG, Goldfarb M |title=The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors. |journal=Mol. Cell. Biol. |volume=8 |issue= 8 |pages= 3487–95 |year= 1989 |pmid= 3211147 |doi=
*cite journal | author=Hébert JM, Rosenquist T, Götz J, Martin GR |title=FGF5 as a regulator of the hair growth cycle: evidence from targeted and spontaneous mutations. |journal=Cell |volume=78 |issue= 6 |pages= 1017–25 |year= 1994 |pmid= 7923352 |doi=
*cite journal | author=Li JJ, Huang YQ, Moscatelli D, "et al." |title=Expression of fibroblast growth factors and their receptors in acquired immunodeficiency syndrome-associated Kaposi sarcoma tissue and derived cells. |journal=Cancer |volume=72 |issue= 7 |pages= 2253–9 |year= 1993 |pmid= 8374885 |doi=
*cite journal | author=Clements DA, Wang JK, Dionne CA, Goldfarb M |title=Activation of fibroblast growth factor (FGF) receptors by recombinant human FGF-5. |journal=Oncogene |volume=8 |issue= 5 |pages= 1311–6 |year= 1993 |pmid= 8386828 |doi=
*cite journal | author=Ornitz DM, Xu J, Colvin JS, "et al." |title=Receptor specificity of the fibroblast growth factor family. |journal=J. Biol. Chem. |volume=271 |issue= 25 |pages= 15292–7 |year= 1996 |pmid= 8663044 |doi=
*cite journal | author=Kitaoka T, Morse LS, Schneeberger S, "et al." |title=Expression of FGF5 in choroidal neovascular membranes associated with ARMD. |journal=Curr. Eye Res. |volume=16 |issue= 4 |pages= 396–9 |year= 1997 |pmid= 9134330 |doi=
*cite journal | author=Schneeberger SA, Hjelmeland LM, Tucker RP, Morse LS |title=Vascular endothelial growth factor and fibroblast growth factor 5 are colocalized in vascular and avascular epiretinal membranes. |journal=Am. J. Ophthalmol. |volume=124 |issue= 4 |pages= 447–54 |year= 1997 |pmid= 9323936 |doi=
*cite journal | author=Kornmann M, Ishiwata T, Beger HG, Korc M |title=Fibroblast growth factor-5 stimulates mitogenic signaling and is overexpressed in human pancreatic cancer: evidence for autocrine and paracrine actions. |journal=Oncogene |volume=15 |issue= 12 |pages= 1417–24 |year= 1997 |pmid= 9333017 |doi= 10.1038/sj.onc.1201307
*cite journal | author=Ozawa K, Suzuki S, Asada M, "et al." |title=An alternatively spliced fibroblast growth factor (FGF)-5 mRNA is abundant in brain and translates into a partial agonist/antagonist for FGF-5 neurotrophic activity. |journal=J. Biol. Chem. |volume=273 |issue= 44 |pages= 29262–71 |year= 1998 |pmid= 9786939 |doi=
*cite journal | author=de Vries CJ, van Achterberg TA, Horrevoets AJ, "et al." |title=Differential display identification of 40 genes with altered expression in activated human smooth muscle cells. Local expression in atherosclerotic lesions of smags, smooth muscle activation-specific genes. |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 23939–47 |year= 2000 |pmid= 10823842 |doi= 10.1074/jbc.M910099199
*cite journal | author=Hanada K, Perry-Lalley DM, Ohnmacht GA, "et al." |title=Identification of fibroblast growth factor-5 as an overexpressed antigen in multiple human adenocarcinomas. |journal=Cancer Res. |volume=61 |issue= 14 |pages= 5511–6 |year= 2001 |pmid= 11454700 |doi=
*cite journal | author=Kornmann M, Lopez ME, Beger HG, Korc M |title=Expression of the IIIc variant of FGF receptor-1 confers mitogenic responsiveness to heparin and FGF-5 in TAKA-1 pancreatic ductal cells. |journal=Int. J. Pancreatol. |volume=29 |issue= 2 |pages= 85–92 |year= 2002 |pmid= 11876253 |doi=
*cite journal | author=Sieuwerts AM, Martens JW, Dorssers LC, "et al." |title=Differential effects of fibroblast growth factors on expression of genes of the plasminogen activator and insulin-like growth factor systems by human breast fibroblasts. |journal=Thromb. Haemost. |volume=87 |issue= 4 |pages= 674–83 |year= 2003 |pmid= 12008951 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

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