SF3B2

Splicing factor 3b, subunit 2, 145kDa, also known as SF3B2, is a human gene.cite web | title = Entrez Gene: SF3B2 splicing factor 3b, subunit 2, 145kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10992| accessdate = ]

PBB_Summary
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summary_text = This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus.cite web | title = Entrez Gene: SF3B2 splicing factor 3b, subunit 2, 145kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10992| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Agell N, Aligué R, Alemany V, "et al." |title=New nuclear functions for calmodulin. |journal=Cell Calcium |volume=23 |issue= 2-3 |pages= 115–21 |year= 1998 |pmid= 9601606 |doi=
*cite journal | author=Champion-Arnaud P, Reed R |title=The prespliceosome components SAP 49 and SAP 145 interact in a complex implicated in tethering U2 snRNP to the branch site. |journal=Genes Dev. |volume=8 |issue= 16 |pages= 1974–83 |year= 1994 |pmid= 7958871 |doi=
*cite journal | author=Gozani O, Feld R, Reed R |title=Evidence that sequence-independent binding of highly conserved U2 snRNP proteins upstream of the branch site is required for assembly of spliceosomal complex A. |journal=Genes Dev. |volume=10 |issue= 2 |pages= 233–43 |year= 1996 |pmid= 8566756 |doi=
*cite journal | author=Neubauer G, King A, Rappsilber J, "et al." |title=Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. |journal=Nat. Genet. |volume=20 |issue= 1 |pages= 46–50 |year= 1998 |pmid= 9731529 |doi= 10.1038/1700
*cite journal | author=Das BK, Xia L, Palandjian L, "et al." |title=Characterization of a protein complex containing spliceosomal proteins SAPs 49, 130, 145, and 155. |journal=Mol. Cell. Biol. |volume=19 |issue= 10 |pages= 6796–802 |year= 2000 |pmid= 10490618 |doi=
*cite journal | author=Das R, Zhou Z, Reed R |title=Functional association of U2 snRNP with the ATP-independent spliceosomal complex E. |journal=Mol. Cell |volume=5 |issue= 5 |pages= 779–87 |year= 2000 |pmid= 10882114 |doi=
*cite journal | author=Bryant HE, Wadd SE, Lamond AI, "et al." |title=Herpes simplex virus IE63 (ICP27) protein interacts with spliceosome-associated protein 145 and inhibits splicing prior to the first catalytic step. |journal=J. Virol. |volume=75 |issue= 9 |pages= 4376–85 |year= 2001 |pmid= 11287586 |doi= 10.1128/JVI.75.9.4376-4385.2001
*cite journal | author=Brand M, Moggs JG, Oulad-Abdelghani M, "et al." |title=UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation. |journal=EMBO J. |volume=20 |issue= 12 |pages= 3187–96 |year= 2001 |pmid= 11406595 |doi= 10.1093/emboj/20.12.3187
*cite journal | author=Will CL, Schneider C, MacMillan AM, "et al." |title=A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site. |journal=EMBO J. |volume=20 |issue= 16 |pages= 4536–46 |year= 2001 |pmid= 11500380 |doi= 10.1093/emboj/20.16.4536
*cite journal | author=Jurica MS, Licklider LJ, Gygi SR, "et al." |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426–39 |year= 2002 |pmid= 11991638 |doi=
*cite journal | author=Will CL, Urlaub H, Achsel T, "et al." |title=Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. |journal=EMBO J. |volume=21 |issue= 18 |pages= 4978–88 |year= 2002 |pmid= 12234937 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Warner DR, Roberts EA, Greene RM, Pisano MM |title=Identification of novel Smad binding proteins. |journal=Biochem. Biophys. Res. Commun. |volume=312 |issue= 4 |pages= 1185–90 |year= 2004 |pmid= 14651998 |doi=
*cite journal | author=Will CL, Schneider C, Hossbach M, "et al." |title=The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. |journal=RNA |volume=10 |issue= 6 |pages= 929–41 |year= 2004 |pmid= 15146077 |doi=
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Lin KT, Lu RM, Tarn WY |title=The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo. |journal=Mol. Cell. Biol. |volume=24 |issue= 20 |pages= 9176–85 |year= 2004 |pmid= 15456888 |doi= 10.1128/MCB.24.20.9176-9185.2004
*cite journal | author=Andersen JS, Lam YW, Leung AK, "et al." |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Ardon O, Zimmerman ES, Andersen JL, "et al." |title=Induction of G2 arrest and binding to cyclophilin A are independent phenotypes of human immunodeficiency virus type 1 Vpr. |journal=J. Virol. |volume=80 |issue= 8 |pages= 3694–700 |year= 2006 |pmid= 16571786 |doi= 10.1128/JVI.80.8.3694-3700.2006

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