AKR1A1

Aldo-keto reductase family 1, member A1 (aldehyde reductase), also known as AKR1A1, is a human gene.cite web | title = Entrez Gene: AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10327| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Alternative splicing of this gene results in two transcript variants encoding the same protein.cite web | title = Entrez Gene: AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10327| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. |journal=J. Infect. |volume=24 |issue= 3 |pages= 317–20 |year= 1992 |pmid= 1602151 |doi=
*cite journal | author=Tanimoto T, Ohta M, Tanaka A, "et al." |title=Purification and characterization of human testis aldose and aldehyde reductase. |journal=Int. J. Biochem. |volume=23 |issue= 4 |pages= 421–8 |year= 1991 |pmid= 1901806 |doi=
*cite journal | author=Vander Jagt DL, Hunsaker LA, Robinson B, "et al." |title=Aldehyde and aldose reductases from human placenta. Heterogeneous expression of multiple enzyme forms. |journal=J. Biol. Chem. |volume=265 |issue= 19 |pages= 10912–8 |year= 1990 |pmid= 2113526 |doi=
*cite journal | author=Bohren KM, Bullock B, Wermuth B, Gabbay KH |title=The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases. |journal=J. Biol. Chem. |volume=264 |issue= 16 |pages= 9547–51 |year= 1989 |pmid= 2498333 |doi=
*cite journal | author=Wermuth B, Omar A, Forster A, "et al." |title=Primary structure of aldehyde reductase from human liver. |journal=Prog. Clin. Biol. Res. |volume=232 |issue= |pages= 297–307 |year= 1987 |pmid= 3615425 |doi=
*cite journal | author=Barski OA, Gabbay KH, Grimshaw CE, Bohren KM |title=Mechanism of human aldehyde reductase: characterization of the active site pocket. |journal=Biochemistry |volume=34 |issue= 35 |pages= 11264–75 |year= 1995 |pmid= 7669785 |doi=
*cite journal | author=Takahashi M, Lu YB, Myint T, "et al." |title=In vivo glycation of aldehyde reductase, a major 3-deoxyglucosone reducing enzyme: identification of glycation sites. |journal=Biochemistry |volume=34 |issue= 4 |pages= 1433–8 |year= 1995 |pmid= 7827091 |doi=
*cite journal | author=Robinson B, Hunsaker LA, Stangebye LA, Vander Jagt DL |title=Aldose and aldehyde reductases from human kidney cortex and medulla. |journal=Biochim. Biophys. Acta |volume=1203 |issue= 2 |pages= 260–6 |year= 1994 |pmid= 8268209 |doi=
*cite journal | author=Sato S, Lin LR, Reddy VN, Kador PF |title=Aldose reductase in human retinal pigment epithelial cells. |journal=Exp. Eye Res. |volume=57 |issue= 2 |pages= 235–41 |year= 1993 |pmid= 8405190 |doi= 10.1006/exer.1993.1119
*cite journal | author=Udovikova EA, Wojtczak L |title=Mitochondrial aldehyde reductase: identification and characterization in rat liver and kidney cortex. |journal=Int. J. Biochem. Cell Biol. |volume=30 |issue= 5 |pages= 597–608 |year= 1998 |pmid= 9693960 |doi=
*cite journal | author=Fujii J, Hamaoka R, Matsumoto A, "et al." |title=The structural organization of the human aldehyde reductase gene, AKR1A1, and mapping to chromosome 1p33-->p32. |journal=Cytogenet. Cell Genet. |volume=84 |issue= 3-4 |pages= 230–2 |year= 1999 |pmid= 10393438 |doi=
*cite journal | author=Barski OA, Gabbay KH, Bohren KM |title=Characterization of the human aldehyde reductase gene and promoter. |journal=Genomics |volume=60 |issue= 2 |pages= 188–98 |year= 1999 |pmid= 10486210 |doi= 10.1006/geno.1999.5915
*cite journal | author=O'connor T, Ireland LS, Harrison DJ, Hayes JD |title=Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members. |journal=Biochem. J. |volume=343 Pt 2 |issue= |pages= 487–504 |year= 1999 |pmid= 10510318 |doi=
*cite journal | author=Picklo MJ, Olson SJ, Markesbery WR, Montine TJ |title=Expression and activities of aldo-keto oxidoreductases in Alzheimer disease. |journal=J. Neuropathol. Exp. Neurol. |volume=60 |issue= 7 |pages= 686–95 |year= 2001 |pmid= 11444797 |doi=
*cite journal | author=Laclau M, Lu F, MacDonald MJ |title=Enzymes in pancreatic islets that use NADP(H) as a cofactor including evidence for a plasma membrane aldehyde reductase. |journal=Mol. Cell. Biochem. |volume=225 |issue= 1- |pages= 151–60 |year= 2002 |pmid= 11716357 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004
*cite journal | author=El-Kabbani O, Green NC, Lin G, "et al." |title=Structures of human and porcine aldehyde reductase: an enzyme implicated in diabetic complications. |journal=Acta Crystallogr. D Biol. Crystallogr. |volume=50 |issue= Pt 6 |pages= 859–68 |year= 2005 |pmid= 15299353 |doi= 10.1107/S0907444994005275
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Bohren KM, Brownlee JM, Milne AC, "et al." |title=The structure of Apo R268A human aldose reductase: hinges and latches that control the kinetic mechanism. |journal=Biochim. Biophys. Acta |volume=1748 |issue= 2 |pages= 201–12 |year= 2005 |pmid= 15769597 |doi= 10.1016/j.bbapap.2005.01.006

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes