CA12

Carbonic anhydrase XII, also known as CA12, is a human gene.cite web | title = Entrez Gene: CA12 carbonic anhydrase XII| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=771| accessdate = ]

PBB_Summary
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summary_text = Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Two transcript variants encoding different isoforms have been identified for this gene.cite web | title = Entrez Gene: CA12 carbonic anhydrase XII| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=771| accessdate = ]

References

Further reading

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citations =
*cite journal | author=Sahin U, Türeci O, Schmitt H, "et al." |title=Human neoplasms elicit multiple specific immune responses in the autologous host. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 25 |pages= 11810–3 |year= 1996 |pmid= 8524854 |doi=
*cite journal | author=Türeci O, Sahin U, Vollmar E, "et al." |title=Human carbonic anhydrase XII: cDNA cloning, expression, and chromosomal localization of a carbonic anhydrase gene that is overexpressed in some renal cell cancers. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 13 |pages= 7608–13 |year= 1998 |pmid= 9636197 |doi=
*cite journal | author=Ivanov SV, Kuzmin I, Wei MH, "et al." |title=Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 21 |pages= 12596–601 |year= 1998 |pmid= 9770531 |doi=
*cite journal | author=Fujikawa-Adachi K, Nishimori I, Taguchi T, Onishi S |title=Human carbonic anhydrase XIV (CA14): cDNA cloning, mRNA expression, and mapping to chromosome 1. |journal=Genomics |volume=61 |issue= 1 |pages= 74–81 |year= 1999 |pmid= 10512682 |doi= 10.1006/geno.1999.5938
*cite journal | author=Karhumaa P, Parkkila S, Türeci O, "et al." |title=Identification of carbonic anhydrase XII as the membrane isozyme expressed in the normal human endometrial epithelium. |journal=Mol. Hum. Reprod. |volume=6 |issue= 1 |pages= 68–74 |year= 2000 |pmid= 10611263 |doi=
*cite journal | author=Kivelä A, Parkkila S, Saarnio J, "et al." |title=Expression of a novel transmembrane carbonic anhydrase isozyme XII in normal human gut and colorectal tumors. |journal=Am. J. Pathol. |volume=156 |issue= 2 |pages= 577–84 |year= 2000 |pmid= 10666387 |doi=
*cite journal | author=Kivelä AJ, Parkkila S, Saarnio J, "et al." |title=Expression of transmembrane carbonic anhydrase isoenzymes IX and XII in normal human pancreas and pancreatic tumours. |journal=Histochem. Cell Biol. |volume=114 |issue= 3 |pages= 197–204 |year= 2001 |pmid= 11083462 |doi=
*cite journal | author=Parkkila S, Parkkila AK, Saarnio J, "et al." |title=Expression of the membrane-associated carbonic anhydrase isozyme XII in the human kidney and renal tumors. |journal=J. Histochem. Cytochem. |volume=48 |issue= 12 |pages= 1601–8 |year= 2001 |pmid= 11101628 |doi=
*cite journal | author=Wykoff CC, Beasley N, Watson PH, "et al." |title=Expression of the hypoxia-inducible and tumor-associated carbonic anhydrases in ductal carcinoma in situ of the breast. |journal=Am. J. Pathol. |volume=158 |issue= 3 |pages= 1011–9 |year= 2001 |pmid= 11238049 |doi=
*cite journal | author=Karhumaa P, Kaunisto K, Parkkila S, "et al." |title=Expression of the transmembrane carbonic anhydrases, CA IX and CA XII, in the human male excurrent ducts. |journal=Mol. Hum. Reprod. |volume=7 |issue= 7 |pages= 611–6 |year= 2001 |pmid= 11420383 |doi=
*cite journal | author=Whittington DA, Waheed A, Ulmasov B, "et al." |title=Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 17 |pages= 9545–50 |year= 2001 |pmid= 11493685 |doi= 10.1073/pnas.161301298
*cite journal | author=Kivela AJ, Saarnio J, Karttunen TJ, "et al." |title=Differential expression of cytoplasmic carbonic anhydrases, CA I and II, and membrane-associated isozymes, CA IX and XII, in normal mucosa of large intestine and in colorectal tumors. |journal=Dig. Dis. Sci. |volume=46 |issue= 10 |pages= 2179–86 |year= 2001 |pmid= 11680594 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Liao SY, Ivanov S, Ivanova A, "et al." |title=Expression of cell surface transmembrane carbonic anhydrase genes CA9 and CA12 in the human eye: overexpression of CA12 (CAXII) in glaucoma. |journal=J. Med. Genet. |volume=40 |issue= 4 |pages= 257–61 |year= 2003 |pmid= 12676895 |doi=
*cite journal | author=Leppilampi M, Saarnio J, Karttunen TJ, "et al." |title=Carbonic anhydrase isozymes IX and XII in gastric tumors. |journal=World J. Gastroenterol. |volume=9 |issue= 7 |pages= 1398–403 |year= 2003 |pmid= 12854129 |doi=
*cite journal | author=Kyllönen MS, Parkkila S, Rajaniemi H, "et al." |title=Localization of carbonic anhydrase XII to the basolateral membrane of H+-secreting cells of mouse and rat kidney. |journal=J. Histochem. Cytochem. |volume=51 |issue= 9 |pages= 1217–24 |year= 2003 |pmid= 12923247 |doi=
*cite journal | author=Tarun AS, Bryant B, Zhai W, "et al." |title=Gene expression for carbonic anhydrase isoenzymes in human nasal mucosa. |journal=Chem. Senses |volume=28 |issue= 7 |pages= 621–9 |year= 2004 |pmid= 14578124 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kivela AJ, Parkkila S, Saarnio J, "et al." |title=Expression of von Hippel-Lindau tumor suppressor and tumor-associated carbonic anhydrases IX and XII in normal and neoplastic colorectal mucosa. |journal=World J. Gastroenterol. |volume=11 |issue= 17 |pages= 2616–25 |year= 2005 |pmid= 15849821 |doi=

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