GPLD1

Glycosylphosphatidylinositol specific phospholipase D1, also known as GPLD1, is a human gene.cite web | title = Entrez Gene: GPLD1 glycosylphosphatidylinositol specific phospholipase D1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2822| accessdate = ]

PBB_Summary
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summary_text = Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane.cite web | title = Entrez Gene: GPLD1 glycosylphosphatidylinositol specific phospholipase D1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2822| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hoener MC, Brodbeck U |title=Phosphatidylinositol-glycan-specific phospholipase D is an amphiphilic glycoprotein that in serum is associated with high-density lipoproteins. |journal=Eur. J. Biochem. |volume=206 |issue= 3 |pages= 747–57 |year= 1992 |pmid= 1606959 |doi=
*cite journal | author=Scallon BJ, Fung WJ, Tsang TC, "et al." |title=Primary structure and functional activity of a phosphatidylinositol-glycan-specific phospholipase D. |journal=Science |volume=252 |issue= 5004 |pages= 446–8 |year= 1991 |pmid= 2017684 |doi=
*cite journal | author=Metz CN, Brunner G, Choi-Muira NH, "et al." |title=Release of GPI-anchored membrane proteins by a cell-associated GPI-specific phospholipase D. |journal=EMBO J. |volume=13 |issue= 7 |pages= 1741–51 |year= 1994 |pmid= 7512501 |doi=
*cite journal | author=Jinnai H, Nakamura S |title=Characterization of phospholipase D activation by GM2 activator in a cell-free system. |journal=The Kobe journal of medical sciences |volume=45 |issue= 3-4 |pages= 181–90 |year= 2000 |pmid= 10752311 |doi=
*cite journal | author=Schofield JN, Rademacher TW |title=Structure and expression of the human glycosylphosphatidylinositol phospholipase D1 (GPLD1) gene. |journal=Biochim. Biophys. Acta |volume=1494 |issue= 1-2 |pages= 189–94 |year= 2000 |pmid= 11072085 |doi=
*cite journal | author=Deeg MA, Bierman EL, Cheung MC |title=GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex. |journal=J. Lipid Res. |volume=42 |issue= 3 |pages= 442–51 |year= 2001 |pmid= 11254757 |doi=
*cite journal | author=Tang J, Li W |title= [Methodological study on the assay of glycosylphosphatidylinositol-specific phospholipase D activity in serum] |journal=Hunan Yi Ke Da Xue Xue Bao |volume=24 |issue= 2 |pages= 119–22 |year= 2002 |pmid= 11938765 |doi=
*cite journal | author=Slomiany A, Nishikawa H, Slomiany BL |title=Screening and modulation of extracellular signals by mucous barrier. Serum glycosylphosphatidylinositol phospholipase D (GPI-PLD) releases protective mucous barrier from oral mucosa. |journal=J. Physiol. Pharmacol. |volume=53 |issue= 1 |pages= 21–38 |year= 2002 |pmid= 11939716 |doi=
*cite journal | author=Jaworek J, Bonio J, Leja-Szpa A, "et al." |title=Sensory nerves in central and peripheral control of pancreatic integrity by leptin and melatonin. |journal=J. Physiol. Pharmacol. |volume=53 |issue= 1 |pages= 51–74 |year= 2002 |pmid= 11939719 |doi=
*cite journal | author=Deeg MA, Bowen RF |title=Phosphorylation decreases trypsin activation and apolipoprotein al binding to glycosylphosphatidylinositol-specific phospholipase D. |journal=Biochem. Cell Biol. |volume=80 |issue= 2 |pages= 253–60 |year= 2002 |pmid= 11989719 |doi=
*cite journal | author=Xiaotong H, Hannocks MJ, Hampson I, Brunner G |title=GPI-specific phospholipase D mRNA expression in tumor cells of different malignancy. |journal=Clin. Exp. Metastasis |volume=19 |issue= 4 |pages= 291–9 |year= 2002 |pmid= 12090469 |doi=
*cite journal | author=Magnusson P, Sharp CA, Farley JR |title=Different distributions of human bone alkaline phosphatase isoforms in serum and bone tissue extracts. |journal=Clin. Chim. Acta |volume=325 |issue= 1-2 |pages= 59–70 |year= 2003 |pmid= 12367767 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Tang JH, Gu SL, Zhang XJ |title= [Preliminary study of the gene structure of human glycosylphosphatidylinositol specific phospholipase D] |journal=Hunan Yi Ke Da Xue Xue Bao |volume=26 |issue= 2 |pages= 95–7 |year= 2003 |pmid= 12536633 |doi=
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Kurtz TA, Fineberg NS, Considine RV, Deeg MA |title=Insulin resistance is associated with increased serum levels of glycosylphosphatidylinositol-specific phospholipase D. |journal=Metab. Clin. Exp. |volume=53 |issue= 2 |pages= 138–9 |year= 2004 |pmid= 14767861 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Lugli EB, Pouliot M, Portela Mdel P, "et al." |title=Characterization of primate trypanosome lytic factors. |journal=Mol. Biochem. Parasitol. |volume=138 |issue= 1 |pages= 9–20 |year= 2005 |pmid= 15500911 |doi= 10.1016/j.molbiopara.2004.07.004
*cite journal | author=Everett PB, Senogles SE |title=D3 dopamine receptor activates phospholipase D through a pertussis toxin-insensitive pathway. |journal=Neurosci. Lett. |volume=371 |issue= 1 |pages= 34–9 |year= 2005 |pmid= 15500962 |doi= 10.1016/j.neulet.2004.08.033
*cite journal | author=Mead KI, Zheng Y, Manzotti CN, "et al." |title=Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells. |journal=J. Immunol. |volume=174 |issue= 8 |pages= 4803–11 |year= 2005 |pmid= 15814706 |doi=

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