SUPT16H

Suppressor of Ty 16 homolog (S. cerevisiae), also known as SUPT16H, is a human gene.cite web | title = Entrez Gene: SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11198| accessdate = ]

PBB_Summary
section_title =
summary_text = Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit, the latter of which is the protein encoded by this gene.cite web | title = Entrez Gene: SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11198| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Orphanides G, LeRoy G, Chang CH, "et al." |title=FACT, a factor that facilitates transcript elongation through nucleosomes. |journal=Cell |volume=92 |issue= 1 |pages= 105–16 |year= 1998 |pmid= 9489704 |doi=
*cite journal | author=LeRoy G, Orphanides G, Lane WS, Reinberg D |title=Requirement of RSF and FACT for transcription of chromatin templates in vitro. |journal=Science |volume=282 |issue= 5395 |pages= 1900–4 |year= 1998 |pmid= 9836642 |doi=
*cite journal | author=Orphanides G, Wu WH, Lane WS, "et al." |title=The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins. |journal=Nature |volume=400 |issue= 6741 |pages= 284–8 |year= 1999 |pmid= 10421373 |doi= 10.1038/22350
*cite journal | author=Kang SW, Kuzuhara T, Horikoshi M |title=Functional interaction of general transcription initiation factor TFIIE with general chromatin factor SPT16/CDC68. |journal=Genes Cells |volume=5 |issue= 4 |pages= 251–63 |year= 2000 |pmid= 10792464 |doi=
*cite journal | author=Wada T, Orphanides G, Hasegawa J, "et al." |title=FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH. |journal=Mol. Cell |volume=5 |issue= 6 |pages= 1067–72 |year= 2000 |pmid= 10912001 |doi=
*cite journal | author=Keller DM, Zeng X, Wang Y, "et al." |title=A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. |journal=Mol. Cell |volume=7 |issue= 2 |pages= 283–92 |year= 2001 |pmid= 11239457 |doi=
*cite journal | author=Keller DM, Lu H |title=p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 50206–13 |year= 2003 |pmid= 12393879 |doi= 10.1074/jbc.M209820200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kitagawa H, Fujiki R, Yoshimura K, "et al." |title=The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome. |journal=Cell |volume=113 |issue= 7 |pages= 905–17 |year= 2003 |pmid= 12837248 |doi=
*cite journal | author=Belotserkovskaya R, Oh S, Bondarenko VA, "et al." |title=FACT facilitates transcription-dependent nucleosome alteration. |journal=Science |volume=301 |issue= 5636 |pages= 1090–3 |year= 2003 |pmid= 12934006 |doi= 10.1126/science.1085703
*cite journal | author=Li J, Hawkins IC, Harvey CD, "et al." |title=Regulation of alternative splicing by SRrp86 and its interacting proteins. |journal=Mol. Cell. Biol. |volume=23 |issue= 21 |pages= 7437–47 |year= 2003 |pmid= 14559993 |doi=
*cite journal | author=Tan BC, Lee SC |title=Nek9, a novel FACT-associated protein, modulates interphase progression. |journal=J. Biol. Chem. |volume=279 |issue= 10 |pages= 9321–30 |year= 2004 |pmid= 14660563 |doi= 10.1074/jbc.M311477200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Fryer CJ, White JB, Jones KA |title=Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. |journal=Mol. Cell |volume=16 |issue= 4 |pages= 509–20 |year= 2005 |pmid= 15546612 |doi= 10.1016/j.molcel.2004.10.014
*cite journal | author=Kouskouti A, Talianidis I |title=Histone modifications defining active genes persist after transcriptional and mitotic inactivation. |journal=EMBO J. |volume=24 |issue= 2 |pages= 347–57 |year= 2005 |pmid= 15616580 |doi= 10.1038/sj.emboj.7600516
*cite journal | author=Huang JY, Chen WH, Chang YL, "et al." |title=Modulation of nucleosome-binding activity of FACT by poly(ADP-ribosyl)ation. |journal=Nucleic Acids Res. |volume=34 |issue= 8 |pages= 2398–407 |year= 2006 |pmid= 16682447 |doi= 10.1093/nar/gkl241
*cite journal | author=Pavri R, Zhu B, Li G, "et al." |title=Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. |journal=Cell |volume=125 |issue= 4 |pages= 703–17 |year= 2006 |pmid= 16713563 |doi= 10.1016/j.cell.2006.04.029
*cite journal | author=Tan BC, Chien CT, Hirose S, Lee SC |title=Functional cooperation between FACT and MCM helicase facilitates initiation of chromatin DNA replication. |journal=EMBO J. |volume=25 |issue= 17 |pages= 3975–85 |year= 2006 |pmid= 16902406 |doi= 10.1038/sj.emboj.7601271
*cite journal | author=Biswas D, Dutta-Biswas R, Mitra D, "et al." |title=Opposing roles for Set2 and yFACT in regulating TBP binding at promoters. |journal=EMBO J. |volume=25 |issue= 19 |pages= 4479–89 |year= 2006 |pmid= 16977311 |doi= 10.1038/sj.emboj.7601333

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