CKMT2

Creatine kinase, mitochondrial 2 (sarcomeric), also known as CKMT2, is a human gene.cite web | title = Entrez Gene: CKMT2 creatine kinase, mitochondrial 2 (sarcomeric)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1160| accessdate = ]

PBB_Summary
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summary_text = Mitochondrial creatine kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Sarcomeric mitochondrial creatine kinase has 80% homology with the coding exons of ubiquitous mitochondrial creatine kinase. This gene contains sequences homologous to several motifs that are shared among some nuclear genes encoding mitochondrial proteins and thus may be essential for the coordinated activation of these genes during mitochondrial biogenesis.cite web | title = Entrez Gene: CKMT2 creatine kinase, mitochondrial 2 (sarcomeric)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1160| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Payne RM, Strauss AW |title=Expression of the mitochondrial creatine kinase genes. |journal=Mol. Cell. Biochem. |volume=133-134 |issue= |pages= 235–43 |year= 1995 |pmid= 7808456 |doi=
*cite journal | author=Qin W, Khuchua Z, Cheng J, "et al." |title=Molecular characterization of the creatine kinases and some historical perspectives. |journal=Mol. Cell. Biochem. |volume=184 |issue= 1-2 |pages= 153–67 |year= 1998 |pmid= 9746319 |doi=
*cite journal | author=Klein SC, Haas RC, Perryman MB, "et al." |title=Regulatory element analysis and structural characterization of the human sarcomeric mitochondrial creatine kinase gene. |journal=J. Biol. Chem. |volume=266 |issue= 27 |pages= 18058–65 |year= 1991 |pmid= 1917943 |doi=
*cite journal | author=Haas RC, Strauss AW |title=Separate nuclear genes encode sarcomere-specific and ubiquitous human mitochondrial creatine kinase isoenzymes. |journal=J. Biol. Chem. |volume=265 |issue= 12 |pages= 6921–7 |year= 1990 |pmid= 2324105 |doi=
*cite journal | author=Haas RC, Korenfeld C, Zhang ZF, "et al." |title=Isolation and characterization of the gene and cDNA encoding human mitochondrial creatine kinase. |journal=J. Biol. Chem. |volume=264 |issue= 5 |pages= 2890–7 |year= 1989 |pmid= 2914937 |doi=
*cite journal | author=Richard I, Devaud C, Cherif D, "et al." |title=The gene for creatine kinase, mitochondrial 2 (sarcomeric; CKMT2), maps to chromosome 5q13.3. |journal=Genomics |volume=18 |issue= 1 |pages= 134–6 |year= 1994 |pmid= 8276398 |doi= 10.1006/geno.1993.1437
*cite journal | author=Qin W, Khuchua Z, Klein SC, Strauss AW |title=Elements regulating cardiomyocyte expression of the human sarcomeric mitochondrial creatine kinase gene in transgenic mice. |journal=J. Biol. Chem. |volume=272 |issue= 40 |pages= 25210–6 |year= 1997 |pmid= 9312135 |doi=
*cite journal | author=Qin W, Khuchua Z, Boero J, "et al." |title=Oxidative myocytes of heart and skeletal muscle express abundant sarcomeric mitochondrial creatine kinase. |journal=Histochem. J. |volume=31 |issue= 6 |pages= 357–65 |year= 1999 |pmid= 10462222 |doi=
*cite journal | author=Kanemitsu F, Mizushima J, Kageoka T, "et al." |title=Characterization of two types of mitochondrial creatine kinase isolated from normal human cardiac muscle and brain tissue. |journal=Electrophoresis |volume=21 |issue= 2 |pages= 266–70 |year= 2000 |pmid= 10674997 |doi= 10.1002/(SICI)1522-2683(20000101)21:2<266::AID-ELPS266>3.0.CO;2-9 |doilabel=10.1002/(SICI)1522-2683(20000101)21:2266::AID-ELPS2663.0.CO;2-9
*cite journal | author=Schlattner U, Wallimann T |title=Octamers of mitochondrial creatine kinase isoenzymes differ in stability and membrane binding. |journal=J. Biol. Chem. |volume=275 |issue= 23 |pages= 17314–20 |year= 2000 |pmid= 10748055 |doi= 10.1074/jbc.M001919200
*cite journal | author=Schlattner U, Wallimann T |title=A quantitative approach to membrane binding of human ubiquitous mitochondrial creatine kinase using surface plasmon resonance. |journal=J. Bioenerg. Biomembr. |volume=32 |issue= 1 |pages= 123–31 |year= 2002 |pmid= 11768757 |doi=
*cite journal | author=Schlattner U, Möckli N, Speer O, "et al." |title=Creatine kinase and creatine transporter in normal, wounded, and diseased skin. |journal=J. Invest. Dermatol. |volume=118 |issue= 3 |pages= 416–23 |year= 2002 |pmid= 11874479 |doi= 10.1046/j.0022-202x.2001.01697.x
*cite journal | author=Wendt S, Schlattner U, Wallimann T |title=Differential effects of peroxynitrite on human mitochondrial creatine kinase isoenzymes. Inactivation, octamer destabilization, and identification of involved residues. |journal=J. Biol. Chem. |volume=278 |issue= 2 |pages= 1125–30 |year= 2003 |pmid= 12401781 |doi= 10.1074/jbc.M208572200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Schlattner U, Gehring F, Vernoux N, "et al." |title=C-terminal lysines determine phospholipid interaction of sarcomeric mitochondrial creatine kinase. |journal=J. Biol. Chem. |volume=279 |issue= 23 |pages= 24334–42 |year= 2004 |pmid= 15044463 |doi= 10.1074/jbc.M314158200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Guerrero K, Wuyam B, Mezin P, "et al." |title=Functional coupling of adenine nucleotide translocase and mitochondrial creatine kinase is enhanced after exercise training in lung transplant skeletal muscle. |journal=Am. J. Physiol. Regul. Integr. Comp. Physiol. |volume=289 |issue= 4 |pages= R1144–54 |year= 2005 |pmid= 16020522 |doi= 10.1152/ajpregu.00229.2005

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