AKAP12

A kinase (PRKA) anchor protein (gravin) 12, also known as AKAP12, is a human gene.cite web | title = Entrez Gene: AKAP12 A kinase (PRKA) anchor protein (gravin) 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9590| accessdate = ]

PBB_Summary
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summary_text = The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms.cite web | title = Entrez Gene: AKAP12 A kinase (PRKA) anchor protein (gravin) 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9590| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lester LB, Scott JD |title=Anchoring and scaffold proteins for kinases and phosphatases. |journal=Recent Prog. Horm. Res. |volume=52 |issue= |pages= 409–29; discussion 429–30 |year= 1997 |pmid= 9238861 |doi=
*cite journal | author=Michel JJ, Scott JD |title=AKAP mediated signal transduction. |journal=Annu. Rev. Pharmacol. Toxicol. |volume=42 |issue= |pages= 235–57 |year= 2002 |pmid= 11807172 |doi= 10.1146/annurev.pharmtox.42.083101.135801
*cite journal | author=Yildirim M, Paydas S, Tanriverdi K, "et al." |title=Gravin gene expression in acute leukaemias: clinical importance and review of the literature. |journal=Leuk. Lymphoma |volume=48 |issue= 6 |pages= 1167–72 |year= 2007 |pmid= 17577780 |doi= 10.1080/10428190701377055
*cite journal | author=Gordon T, Grove B, Loftus JC, "et al." |title=Molecular cloning and preliminary characterization of a novel cytoplasmic antigen recognized by myasthenia gravis sera. |journal=J. Clin. Invest. |volume=90 |issue= 3 |pages= 992–9 |year= 1992 |pmid= 1522245 |doi=
*cite journal | author=Nauert JB, Klauck TM, Langeberg LK, Scott JD |title=Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein. |journal=Curr. Biol. |volume=7 |issue= 1 |pages= 52–62 |year= 1997 |pmid= 9000000 |doi=
*cite journal | author=Sato N, Kokame K, Shimokado K, "et al." |title=Changes of gene expression by lysophosphatidylcholine in vascular endothelial cells: 12 up-regulated distinct genes including 5 cell growth-related, 3 thrombosis-related, and 4 others. |journal=J. Biochem. |volume=123 |issue= 6 |pages= 1119–26 |year= 1998 |pmid= 9604001 |doi=
*cite journal | author=Shih M, Lin F, Scott JD, "et al." |title=Dynamic complexes of beta2-adrenergic receptors with protein kinases and phosphatases and the role of gravin. |journal=J. Biol. Chem. |volume=274 |issue= 3 |pages= 1588–95 |year= 1999 |pmid= 9880537 |doi=
*cite journal | author=Lin F, Wang H, Malbon CC |title=Gravin-mediated formation of signaling complexes in beta 2-adrenergic receptor desensitization and resensitization. |journal=J. Biol. Chem. |volume=275 |issue= 25 |pages= 19025–34 |year= 2000 |pmid= 10858453 |doi=
*cite journal | author=Fan G, Shumay E, Wang H, Malbon CC |title=The scaffold protein gravin (cAMP-dependent protein kinase-anchoring protein 250) binds the beta 2-adrenergic receptor via the receptor cytoplasmic Arg-329 to Leu-413 domain and provides a mobile scaffold during desensitization. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 24005–14 |year= 2001 |pmid= 11309381 |doi= 10.1074/jbc.M011199200
*cite journal | author=Grove BD, Bruchey AK |title=Intracellular distribution of gravin, a PKA and PKC binding protein, in vascular endothelial cells. |journal=J. Vasc. Res. |volume=38 |issue= 2 |pages= 163–75 |year= 2001 |pmid= 11316952 |doi=
*cite journal | author=Sasaki H, Kunimatsu M, Fujii Y, "et al." |title=Autoantibody to gravin is expressed more strongly in younger and nonthymomatous patients with myasthenia gravis. |journal=Surg. Today |volume=31 |issue= 11 |pages= 1036–7 |year= 2002 |pmid= 11766078 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Piontek J, Brandt R |title=Differential and regulated binding of cAMP-dependent protein kinase and protein kinase C isoenzymes to gravin in human model neurons: Evidence that gravin provides a dynamic platform for the localization for kinases during neuronal development. |journal=J. Biol. Chem. |volume=278 |issue= 40 |pages= 38970–9 |year= 2003 |pmid= 12857743 |doi= 10.1074/jbc.M306749200
*cite journal | author=Tao J, Wang HY, Malbon CC |title=Protein kinase A regulates AKAP250 (gravin) scaffold binding to the beta2-adrenergic receptor. |journal=EMBO J. |volume=22 |issue= 24 |pages= 6419–29 |year= 2004 |pmid= 14657015 |doi= 10.1093/emboj/cdg628
*cite journal | author=Choi MC, Jong HS, Kim TY, "et al." |title=AKAP12/Gravin is inactivated by epigenetic mechanism in human gastric carcinoma and shows growth suppressor activity. |journal=Oncogene |volume=23 |issue= 42 |pages= 7095–103 |year= 2004 |pmid= 15258566 |doi= 10.1038/sj.onc.1207932
*cite journal | author=Ballif BA, Villén J, Beausoleil SA, "et al." |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell Proteomics |volume=3 |issue= 11 |pages= 1093–101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200
*cite journal | author=Streb JW, Miano JM |title=AKAP12alpha, an atypical serum response factor-dependent target gene. |journal=J. Biol. Chem. |volume=280 |issue= 6 |pages= 4125–34 |year= 2005 |pmid= 15590635 |doi= 10.1074/jbc.M412466200
*cite journal | author=Streb JW, Miano JM |title=Cross-species sequence analysis reveals multiple charged residue-rich domains that regulate nuclear/cytoplasmic partitioning and membrane localization of a kinase anchoring protein 12 (SSeCKS/Gravin). |journal=J. Biol. Chem. |volume=280 |issue= 30 |pages= 28007–14 |year= 2005 |pmid= 15923193 |doi= 10.1074/jbc.M414017200

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