ARHGEF2

Rho/rac guanine nucleotide exchange factor (GEF) 2, also known as ARHGEF2, is a human gene.cite web | title = Entrez Gene: ARHGEF2 rho/rac guanine nucleotide exchange factor (GEF) 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9181| accessdate = ]

PBB_Summary
section_title =
summary_text = Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals.cite web | title = Entrez Gene: ARHGEF2 rho/rac guanine nucleotide exchange factor (GEF) 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9181| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ehrhardt A, Ehrhardt GR, Guo X, Schrader JW |title=Ras and relatives--job sharing and networking keep an old family together. |journal=Exp. Hematol. |volume=30 |issue= 10 |pages= 1089–106 |year= 2002 |pmid= 12384139 |doi=
*cite journal | author=Reddy AB, Chatterjee A, Rothblum LI, "et al." |title=Isolation and characterization of complementary DNA to proliferating cell nucleolar antigen P40. |journal=Cancer Res. |volume=49 |issue= 7 |pages= 1763–7 |year= 1989 |pmid= 2466560 |doi=
*cite journal | author=Ishikawa K, Nagase T, Suyama M, "et al." |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 3 |pages= 169–76 |year= 1998 |pmid= 9734811 |doi=
*cite journal | author=Ren Y, Li R, Zheng Y, Busch H |title=Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases. |journal=J. Biol. Chem. |volume=273 |issue= 52 |pages= 34954–60 |year= 1999 |pmid= 9857026 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Gao Y, Xing J, Streuli M, "et al." |title=Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors. |journal=J. Biol. Chem. |volume=276 |issue= 50 |pages= 47530–41 |year= 2002 |pmid= 11595749 |doi= 10.1074/jbc.M108865200
*cite journal | author=Krendel M, Zenke FT, Bokoch GM |title=Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton. |journal=Nat. Cell Biol. |volume=4 |issue= 4 |pages= 294–301 |year= 2002 |pmid= 11912491 |doi= 10.1038/ncb773
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Brajenovic M, Joberty G, Küster B, "et al." |title=Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. |journal=J. Biol. Chem. |volume=279 |issue= 13 |pages= 12804–11 |year= 2004 |pmid= 14676191 |doi= 10.1074/jbc.M312171200
*cite journal | author=Bouwmeester T, Bauch A, Ruffner H, "et al." |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086
*cite journal | author=Zenke FT, Krendel M, DerMardirossian C, "et al." |title=p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor. |journal=J. Biol. Chem. |volume=279 |issue= 18 |pages= 18392–400 |year= 2004 |pmid= 14970201 |doi= 10.1074/jbc.M400084200
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Jin J, Smith FD, Stark C, "et al." |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051
*cite journal | author=Wiemann S, Arlt D, Huber W, "et al." |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704
*cite journal | author=Callow MG, Zozulya S, Gishizky ML, "et al." |title=PAK4 mediates morphological changes through the regulation of GEF-H1. |journal=J. Cell. Sci. |volume=118 |issue= Pt 9 |pages= 1861–72 |year= 2005 |pmid= 15827085 |doi= 10.1242/jcs.02313
*cite journal | author=Aijaz S, D'Atri F, Citi S, "et al." |title=Binding of GEF-H1 to the tight junction-associated adaptor cingulin results in inhibition of Rho signaling and G1/S phase transition. |journal=Dev. Cell |volume=8 |issue= 5 |pages= 777–86 |year= 2005 |pmid= 15866167 |doi= 10.1016/j.devcel.2005.03.003
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Mehrle A, Rosenfelder H, Schupp I, "et al." |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139

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