PLIN

PLIN

Perilipin, also known as PLIN, is a human gene.cite web | title = Entrez Gene: PLIN perilipin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5346| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene coats lipid storage droplets in adipocytes, thereby protecting them until they can be broken down by hormone-sensitive lipase. The encoded protein is the major cAMP-dependent protein kinase substrate in adipocytes and, when unphosphorylated, may play a role in the inhibition of lipolysis.cite web | title = Entrez Gene: PLIN perilipin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5346| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Tai ES, Ordovas JM |title=The role of perilipin in human obesity and insulin resistance. |journal=Curr. Opin. Lipidol. |volume=18 |issue= 2 |pages= 152–6 |year= 2007 |pmid= 17353663 |doi= 10.1097/MOL.0b013e328086aeab
*cite journal | author=Nishiu J, Tanaka T, Nakamura Y |title=Isolation and chromosomal mapping of the human homolog of perilipin (PLIN), a rat adipose tissue-specific gene, by differential display method. |journal=Genomics |volume=48 |issue= 2 |pages= 254–7 |year= 1998 |pmid= 9521880 |doi= 10.1006/geno.1997.5179
*cite journal | author=Souza SC, Muliro KV, Liscum L, "et al." |title=Modulation of hormone-sensitive lipase and protein kinase A-mediated lipolysis by perilipin A in an adenoviral reconstituted system. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8267–72 |year= 2002 |pmid= 11751901 |doi= 10.1074/jbc.M108329200
*cite journal | author=Hagström-Toft E, Qvisth V, Nennesmo I, "et al." |title=Marked heterogeneity of human skeletal muscle lipolysis at rest. |journal=Diabetes |volume=51 |issue= 12 |pages= 3376–83 |year= 2002 |pmid= 12453889 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Mottagui-Tabar S, Rydén M, Löfgren P, "et al." |title=Evidence for an important role of perilipin in the regulation of human adipocyte lipolysis. |journal=Diabetologia |volume=46 |issue= 6 |pages= 789–97 |year= 2004 |pmid= 12802495 |doi= 10.1007/s00125-003-1112-x
*cite journal | author=Wang Y, Sullivan S, Trujillo M, "et al." |title=Perilipin expression in human adipose tissues: effects of severe obesity, gender, and depot. |journal=Obes. Res. |volume=11 |issue= 8 |pages= 930–6 |year= 2004 |pmid= 12917496 |doi=
*cite journal | author=Zhang HH, Souza SC, Muliro KV, "et al." |title=Lipase-selective functional domains of perilipin A differentially regulate constitutive and protein kinase A-stimulated lipolysis. |journal=J. Biol. Chem. |volume=278 |issue= 51 |pages= 51535–42 |year= 2004 |pmid= 14527948 |doi= 10.1074/jbc.M309591200
*cite journal | author=Kern PA, Di Gregorio G, Lu T, "et al." |title=Perilipin expression in human adipose tissue is elevated with obesity. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 3 |pages= 1352–8 |year= 2004 |pmid= 15001633 |doi=
*cite journal | author=Arvidsson E, Blomqvist L, Rydén M |title=Depot-specific differences in perilipin mRNA but not protein expression in obesity. |journal=J. Intern. Med. |volume=255 |issue= 5 |pages= 595–601 |year= 2004 |pmid= 15078502 |doi= 10.1111/j.1365-2796.2004.01314.x
*cite journal | author=Dalen KT, Schoonjans K, Ulven SM, "et al." |title=Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gamma. |journal=Diabetes |volume=53 |issue= 5 |pages= 1243–52 |year= 2004 |pmid= 15111493 |doi=
*cite journal | author=Qi L, Corella D, Sorlí JV, "et al." |title=Genetic variation at the perilipin (PLIN) locus is associated with obesity-related phenotypes in White women. |journal=Clin. Genet. |volume=66 |issue= 4 |pages= 299–310 |year= 2005 |pmid= 15355432 |doi= 10.1111/j.1399-0004.2004.00309.x
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Yan W, Chen S, Huang J, "et al." |title=Polymorphisms in PLIN and hypertension combined with obesity and lipid profiles in Han Chinese. |journal=Obes. Res. |volume=12 |issue= 11 |pages= 1733–7 |year= 2005 |pmid= 15601966 |doi=
*cite journal | author=Qi L, Shen H, Larson I, "et al." |title=Gender-specific association of a perilipin gene haplotype with obesity risk in a white population. |journal=Obes. Res. |volume=12 |issue= 11 |pages= 1758–65 |year= 2005 |pmid= 15601970 |doi=
*cite journal | author=Qi L, Tai ES, Tan CE, "et al." |title=Intragenic linkage disequilibrium structure of the human perilipin gene (PLIN) and haplotype association with increased obesity risk in a multiethnic Asian population. |journal=J. Mol. Med. |volume=83 |issue= 6 |pages= 448–56 |year= 2005 |pmid= 15770500 |doi= 10.1007/s00109-004-0630-4
*cite journal | author=Forcheron F, Legedz L, Chinetti G, "et al." |title=Genes of cholesterol metabolism in human atheroma: overexpression of perilipin and genes promoting cholesterol storage and repression of ABCA1 expression. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=25 |issue= 8 |pages= 1711–7 |year= 2005 |pmid= 15961705 |doi= 10.1161/01.ATV.0000174123.19103.52
*cite journal | author=Corella D, Qi L, Sorlí JV, "et al." |title=Obese subjects carrying the 11482G>A polymorphism at the perilipin locus are resistant to weight loss after dietary energy restriction. |journal=J. Clin. Endocrinol. Metab. |volume=90 |issue= 9 |pages= 5121–6 |year= 2005 |pmid= 15985482 |doi= 10.1210/jc.2005-0576
*cite journal | author=Moore HP, Silver RB, Mottillo EP, "et al." |title=Perilipin targets a novel pool of lipid droplets for lipolytic attack by hormone-sensitive lipase. |journal=J. Biol. Chem. |volume=280 |issue= 52 |pages= 43109–20 |year= 2006 |pmid= 16243839 |doi= 10.1074/jbc.M506336200
*cite journal | author=Shimizu M, Akter MH, Emi Y, "et al." |title=Peroxisome proliferator-activated receptor subtypes differentially cooperate with other transcription factors in selective transactivation of the perilipin/PEX11 alpha gene pair. |journal=J. Biochem. |volume=139 |issue= 3 |pages= 563–73 |year= 2007 |pmid= 16567422 |doi= 10.1093/jb/mvj053

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  • plin — plin, a mí, plin expr. no importar, ser indiferente. ❙ «...porque, la verdad, todo eso a mi: ¡plin!» A. Zamora Vicente, Desorganización. ❙ ▄▀ ❙ «Puedes comprar ese coche si quieres. A mí, plin.» …   Diccionario del Argot "El Sohez"

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  • plin — ► locución Significa que no tiene importancia o que no importa lo más mínimo en la expresión ¡a mí, plin!: ■ si no vienes, ¡a mí, plin!, pero luego asume las consecuencias. * * * plin A mí, plin (inf.). Expresión utilizada para denotar… …   Enciclopedia Universal

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