AFF1

AF4/FMR2 family, member 1, also known as AFF1, is a human gene.cite web | title = Entrez Gene: AFF1 AF4/FMR2 family, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4299| accessdate = ]

PBB_Summary
section_title =
summary_text = DISCONTINUED: The record for PBM1 has been withdrawn by HGNC.cite web | title = Entrez Gene: AFF1 AF4/FMR2 family, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4299| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gu Y, Nakamura T, Alder H, "et al." |title=The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene. |journal=Cell |volume=71 |issue= 4 |pages= 701–8 |year= 1992 |pmid= 1423625 |doi=
*cite journal | author=Domer PH, Fakharzadeh SS, Chen CS, "et al." |title=Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 16 |pages= 7884–8 |year= 1993 |pmid= 7689231 |doi=
*cite journal | author=Chen CS, Hilden JM, Frestedt J, "et al." |title=The chromosome 4q21 gene (AF-4/FEL) is widely expressed in normal tissues and shows breakpoint diversity in t(4;11)(q21;q23) acute leukemia. |journal=Blood |volume=82 |issue= 4 |pages= 1080–5 |year= 1993 |pmid= 8353274 |doi=
*cite journal | author=Morrissey J, Tkachuk DC, Milatovich A, "et al." |title=A serine/proline-rich protein is fused to HRX in t(4;11) acute leukemias. |journal=Blood |volume=81 |issue= 5 |pages= 1124–31 |year= 1993 |pmid= 8443374 |doi=
*cite journal | author=Nakamura T, Alder H, Gu Y, "et al." |title=Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 10 |pages= 4631–5 |year= 1993 |pmid= 8506309 |doi=
*cite journal | author=Frestedt JL, Hilden JM, Kersey JH |title=AF4/FEL, a gene involved in infant leukemia: sequence variations, gene structure, and possible homology with a genomic sequence on 5q31. |journal=DNA Cell Biol. |volume=15 |issue= 8 |pages= 669–78 |year= 1996 |pmid= 8769569 |doi=
*cite journal | author=Nilson I, Reichel M, Ennas MG, "et al." |title=Exon/intron structure of the human AF-4 gene, a member of the AF-4/LAF-4/FMR-2 gene family coding for a nuclear protein with structural alterations in acute leukaemia. |journal=Br. J. Haematol. |volume=98 |issue= 1 |pages= 157–69 |year= 1997 |pmid= 9233580 |doi=
*cite journal | author=Megonigal MD, Rappaport EF, Jones DH, "et al." |title=Panhandle PCR strategy to amplify MLL genomic breakpoints in treatment-related leukemias. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 21 |pages= 11583–8 |year= 1997 |pmid= 9326653 |doi=
*cite journal | author=Felix CA, Kim CS, Megonigal MD, "et al." |title=Panhandle polymerase chain reaction amplifies MLL genomic translocation breakpoint involving unknown partner gene. |journal=Blood |volume=90 |issue= 12 |pages= 4679–86 |year= 1997 |pmid= 9389682 |doi=
*cite journal | author=Isnard P, Depetris D, Mattei MG, "et al." |title=cDNA cloning, expression and chromosomal localization of the murine AF-4 gene involved in human leukemia. |journal=Mamm. Genome |volume=9 |issue= 12 |pages= 1065–8 |year= 1999 |pmid= 9880680 |doi=
*cite journal | author=Felix CA, Hosler MR, Slater DJ, "et al." |title=Duplicated regions of AF-4 intron 4 at t(4;11) translocation breakpoints. |journal=Mol. Diagn. |volume=4 |issue= 4 |pages= 269–83 |year= 2000 |pmid= 10671636 |doi= 10.154/MODI00400269
*cite journal | author=Reichel M, Gillert E, Breitenlohner I, "et al." |title=Rapid isolation of chromosomal breakpoints from patients with t(4;11) acute lymphoblastic leukemia: implications for basic and clinical research. |journal=Leukemia |volume=15 |issue= 2 |pages= 286–8 |year= 2001 |pmid= 11236948 |doi=
*cite journal | author=Raffini LJ, Slater DJ, Rappaport EF, "et al." |title=Panhandle and reverse-panhandle PCR enable cloning of der(11) and der(other) genomic breakpoint junctions of MLL translocations and identify complex translocation of MLL, AF-4, and CDK6. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 7 |pages= 4568–73 |year= 2002 |pmid= 11930009 |doi= 10.1073/pnas.062066799
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Bertrand FE, Spengeman JD, Shah N, LeBien TW |title=B-cell development in the presence of the MLL/AF4 oncoprotein proceeds in the absence of HOX A7 and HOX A9 expression. |journal=Leukemia |volume=17 |issue= 12 |pages= 2454–9 |year= 2004 |pmid= 14562113 |doi= 10.1038/sj.leu.2403178
*cite journal | author=Caslini C, Serna A, Rossi V, "et al." |title=Modulation of cell cycle by graded expression of MLL-AF4 fusion oncoprotein. |journal=Leukemia |volume=18 |issue= 6 |pages= 1064–71 |year= 2004 |pmid= 14990976 |doi= 10.1038/sj.leu.2403321
*cite journal | author=Bursen A, Moritz S, Gaussmann A, "et al." |title=Interaction of AF4 wild-type and AF4.MLL fusion protein with SIAH proteins: indication for t(4;11) pathobiology? |journal=Oncogene |volume=23 |issue= 37 |pages= 6237–49 |year= 2004 |pmid= 15221006 |doi= 10.1038/sj.onc.1207837
*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Xia ZB, Popovic R, Chen J, "et al." |title=The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 39 |pages= 14028–33 |year= 2005 |pmid= 16169901 |doi= 10.1073/pnas.0506464102

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