SEC14L2

SEC14L2

SEC14-like 2 (S. cerevisiae), also known as SEC14L2, is a human gene.cite web | title = Entrez Gene: SEC14L2 SEC14-like 2 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23541| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway.cite web | title = Entrez Gene: SEC14L2 SEC14-like 2 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23541| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Caras IW, Friedlander EJ, Bloch K |title=Interactions of supernatant protein factor with components of the microsomal squalene epoxidase system. Binding of supernatant protein factor to anionic phospholipids. |journal=J. Biol. Chem. |volume=255 |issue= 8 |pages= 3575–80 |year= 1980 |pmid= 7364757 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Solheim JC, Harris MR, Kindle CS, Hansen TH |title=Prominence of beta 2-microglobulin, class I heavy chain conformation, and tapasin in the interactions of class I heavy chain with calreticulin and the transporter associated with antigen processing. |journal=J. Immunol. |volume=158 |issue= 5 |pages= 2236–41 |year= 1997 |pmid= 9036970 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=
*cite journal | author=Hirosawa M, Nagase T, Ishikawa K, "et al." |title=Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. |journal=DNA Res. |volume=6 |issue= 5 |pages= 329–36 |year= 2000 |pmid= 10574461 |doi=
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=Zimmer S, Stocker A, Sarbolouki MN, "et al." |title=A novel human tocopherol-associated protein: cloning, in vitro expression, and characterization. |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25672–80 |year= 2000 |pmid= 10829015 |doi= 10.1074/jbc.M000851200
*cite journal | author=Shibata N, Arita M, Misaki Y, "et al." |title=Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 5 |pages= 2244–9 |year= 2001 |pmid= 11226224 |doi= 10.1073/pnas.041620398
*cite journal | author=Hirosawa M, Nagase T, Murahashi Y, "et al." |title=Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. |journal=DNA Res. |volume=8 |issue= 1 |pages= 1–9 |year= 2001 |pmid= 11258795 |doi=
*cite journal | author=Yamauchi J, Iwamoto T, Kida S, "et al." |title=Tocopherol-associated protein is a ligand-dependent transcriptional activator. |journal=Biochem. Biophys. Res. Commun. |volume=285 |issue= 2 |pages= 295–9 |year= 2001 |pmid= 11444841 |doi= 10.1006/bbrc.2001.5162
*cite journal | author=Stocker A, Tomizaki T, Schulze-Briese C, Baumann U |title=Crystal structure of the human supernatant protein factor. |journal=Structure |volume=10 |issue= 11 |pages= 1533–40 |year= 2003 |pmid= 12429094 |doi=
*cite journal | author=Singh DK, Mokashi V, Elmore CL, Porter TD |title=Phosphorylation of supernatant protein factor enhances its ability to stimulate microsomal squalene monooxygenase. |journal=J. Biol. Chem. |volume=278 |issue= 8 |pages= 5646–51 |year= 2003 |pmid= 12454003 |doi= 10.1074/jbc.M211750200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kempná P, Zingg JM, Ricciarelli R, "et al." |title=Cloning of novel human SEC14p-like proteins: ligand binding and functional properties. |journal=Free Radic. Biol. Med. |volume=34 |issue= 11 |pages= 1458–72 |year= 2004 |pmid= 12757856 |doi=
*cite journal | author=Stocker A, Baumann U |title=Supernatant protein factor in complex with RRR-alpha-tocopherylquinone: a link between oxidized Vitamin E and cholesterol biosynthesis. |journal=J. Mol. Biol. |volume=332 |issue= 4 |pages= 759–65 |year= 2003 |pmid= 12972248 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Mokashi V, Singh DK, Porter TD |title=Rat supernatant protein factor-like protein stimulates squalene monooxygenase and is activated by protein kinase A. |journal=Biochem. Biophys. Res. Commun. |volume=316 |issue= 3 |pages= 688–92 |year= 2004 |pmid= 15033454 |doi= 10.1016/j.bbrc.2004.02.103
*cite journal | author=Collins JE, Wright CL, Edwards CA, "et al." |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84
*cite journal | author=Cheng J, Kapranov P, Drenkow J, "et al." |title=Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution. |journal=Science |volume=308 |issue= 5725 |pages= 1149–54 |year= 2005 |pmid= 15790807 |doi= 10.1126/science.1108625

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  • CRAL-TRIO domain — Pfam box Symbol = CRAL TRIO Name = width =200 caption = Alpha tocopherol transfer protein, closed state with ligand Pfam= PF00650 InterPro= IPR001251 SMART= Prosite = SCOP = 1aua TCDB = OPM family= 129 OPM protein= 1r5l PDB=PDB3|1aua :108 294… …   Wikipedia

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