CNTN2

Contactin 2 (axonal), also known as CNTN2, is a human gene.cite web | title = Entrez Gene: CNTN2 contactin 2 (axonal)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6900| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. It may also be involved in glial tumorigenesis and may provide a potential target for therapeutic intervention.cite web | title = Entrez Gene: CNTN2 contactin 2 (axonal)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6900| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Walsh FS, Doherty P |title=Glycosylphosphatidylinositol anchored recognition molecules that function in axonal fasciculation, growth and guidance in the nervous system. |journal=Cell Biol. Int. Rep. |volume=15 |issue= 11 |pages= 1151–66 |year= 1992 |pmid= 1838307 |doi=
*cite journal | author=Kuhn TB, Stoeckli ET, Condrau MA, "et al." |title=Neurite outgrowth on immobilized axonin-1 is mediated by a heterophilic interaction with L1(G4). |journal=J. Cell Biol. |volume=115 |issue= 4 |pages= 1113–26 |year= 1991 |pmid= 1720120 |doi=
*cite journal | author=Dodd J, Morton SB, Karagogeos D, "et al." |title=Spatial regulation of axonal glycoprotein expression on subsets of embryonic spinal neurons. |journal=Neuron |volume=1 |issue= 2 |pages= 105–16 |year= 1990 |pmid= 3272160 |doi=
*cite journal | author=Kenwrick S, Leversha M, Rooke L, "et al." |title=Localization of the human TAX-1 gene to 1q32.1: a region implicated in microcephaly and Van der Woude syndrome. |journal=Hum. Mol. Genet. |volume=2 |issue= 9 |pages= 1461–2 |year= 1993 |pmid= 8242070 |doi=
*cite journal | author=Tsiotra PC, Karagogeos D, Theodorakis K, "et al." |title=Isolation of the cDNA and chromosomal localization of the gene (TAX1) encoding the human axonal glycoprotein TAG-1. |journal=Genomics |volume=18 |issue= 3 |pages= 562–7 |year= 1994 |pmid= 8307567 |doi=
*cite journal | author=Rader C, Stoeckli ET, Ziegler U, "et al." |title=Cell-cell adhesion by homophilic interaction of the neuronal recognition molecule axonin-1. |journal=Eur. J. Biochem. |volume=215 |issue= 1 |pages= 133–41 |year= 1993 |pmid= 8344273 |doi=
*cite journal | author=Hasler TH, Rader C, Stoeckli ET, "et al." |title=cDNA cloning, structural features, and eucaryotic expression of human TAG-1/axonin-1. |journal=Eur. J. Biochem. |volume=211 |issue= 1-2 |pages= 329–39 |year= 1993 |pmid= 8425542 |doi=
*cite journal | author=Kozlov SV, Giger RJ, Hasler T, "et al." |title=The human TAX1 gene encoding the axon-associated cell adhesion molecule TAG-1/axonin-1: genomic structure and basic promoter. |journal=Genomics |volume=30 |issue= 2 |pages= 141–8 |year= 1996 |pmid= 8586412 |doi= 10.1006/geno.1995.9892
*cite journal | author=Yoshihara Y, Kawasaki M, Tamada A, "et al." |title=Overlapping and differential expression of BIG-2, BIG-1, TAG-1, and F3: four members of an axon-associated cell adhesion molecule subgroup of the immunoglobulin superfamily. |journal=J. Neurobiol. |volume=28 |issue= 1 |pages= 51–69 |year= 1996 |pmid= 8586965 |doi= 10.1002/neu.480280106
*cite journal | author=Milev P, Maurel P, Häring M, "et al." |title=TAG-1/axonin-1 is a high-affinity ligand of neurocan, phosphacan/protein-tyrosine phosphatase-zeta/beta, and N-CAM. |journal=J. Biol. Chem. |volume=271 |issue= 26 |pages= 15716–23 |year= 1996 |pmid= 8663515 |doi=
*cite journal | author=Pise-Masison CA, Dittmer J, Clemens KE, Brady JN |title=Physical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-Y. |journal=Mol. Cell. Biol. |volume=17 |issue= 3 |pages= 1236–43 |year= 1997 |pmid= 9032250 |doi=
*cite journal | author=Williams H, Schachner M, Wang B, Kenwrick S |title=Radiation hybrid mapping of the genes for tenascin-R (TNR), phosducin (PDC), laminin C1 (LAMC1), and TAX in 1q25-q32. |journal=Genomics |volume=46 |issue= 1 |pages= 165–6 |year= 1998 |pmid= 9403076 |doi= 10.1006/geno.1997.4994
*cite journal | author=Malhotra JD, Tsiotra P, Karagogeos D, Hortsch M |title=Cis-activation of L1-mediated ankyrin recruitment by TAG-1 homophilic cell adhesion. |journal=J. Biol. Chem. |volume=273 |issue= 50 |pages= 33354–9 |year= 1999 |pmid= 9837910 |doi=
*cite journal | author=Freigang J, Proba K, Leder L, "et al." |title=The crystal structure of the ligand binding module of axonin-1/TAG-1 suggests a zipper mechanism for neural cell adhesion. |journal=Cell |volume=101 |issue= 4 |pages= 425–33 |year= 2000 |pmid= 10830169 |doi=
*cite journal | author=Rickman DS, Tyagi R, Zhu XX, "et al." |title=The gene for the axonal cell adhesion molecule TAX-1 is amplified and aberrantly expressed in malignant gliomas. |journal=Cancer Res. |volume=61 |issue= 5 |pages= 2162–8 |year= 2001 |pmid= 11280781 |doi=
*cite journal | author=Pavlou O, Theodorakis K, Falk J, "et al." |title=Analysis of interactions of the adhesion molecule TAG-1 and its domains with other immunoglobulin superfamily members. |journal=Mol. Cell. Neurosci. |volume=20 |issue= 3 |pages= 367–81 |year= 2002 |pmid= 12139915 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Traka M, Goutebroze L, Denisenko N, "et al." |title=Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers. |journal=J. Cell Biol. |volume=162 |issue= 6 |pages= 1161–72 |year= 2003 |pmid= 12975355 |doi= 10.1083/jcb.200305078
*cite journal | author=Nagaraja GM, Kandpal RP |title=Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins. |journal=Biochem. Biophys. Res. Commun. |volume=313 |issue= 3 |pages= 654–65 |year= 2004 |pmid= 14697242 |doi=

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