STIL

STIL

SCL/TAL1 interrupting locus, also known as STIL, is a human gene.cite web | title = Entrez Gene: STIL SCL/TAL1 interrupting locus| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6491| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: STIL SCL/TAL1 interrupting locus| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6491| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Aplan PD, Lombardi DP, Reaman GH, "et al." |title=Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia. |journal=Blood |volume=79 |issue= 5 |pages= 1327–33 |year= 1992 |pmid= 1311214 |doi=
*cite journal | author=Aplan PD, Lombardi DP, Kirsch IR |title=Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia. |journal=Mol. Cell. Biol. |volume=11 |issue= 11 |pages= 5462–9 |year= 1991 |pmid= 1922059 |doi=
*cite journal | author=Jonsson OG, Kitchens RL, Baer RJ, "et al." |title=Rearrangements of the tal-1 locus as clonal markers for T cell acute lymphoblastic leukemia. |journal=J. Clin. Invest. |volume=87 |issue= 6 |pages= 2029–35 |year= 1991 |pmid= 2040693 |doi=
*cite journal | author=Brown L, Cheng JT, Chen Q, "et al." |title=Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia. |journal=EMBO J. |volume=9 |issue= 10 |pages= 3343–51 |year= 1990 |pmid= 2209547 |doi=
*cite journal | author=Aplan PD, Lombardi DP, Ginsberg AM, "et al." |title=Disruption of the human SCL locus by "illegitimate" V-(D)-J recombinase activity. |journal=Science |volume=250 |issue= 4986 |pages= 1426–9 |year= 1991 |pmid= 2255914 |doi=
*cite journal | author=Kikuchi A, Hayashi Y, Kobayashi S, "et al." |title=Clinical significance of TAL1 gene alteration in childhood T-cell acute lymphoblastic leukemia and lymphoma. |journal=Leukemia |volume=7 |issue= 7 |pages= 933–8 |year= 1993 |pmid= 8321044 |doi=
*cite journal | author=Collazo-Garcia N, Scherer P, Aplan PD |title=Cloning and characterization of a murine SIL gene. |journal=Genomics |volume=30 |issue= 3 |pages= 506–13 |year= 1997 |pmid= 8825637 |doi= 10.1006/geno.1995.1271
*cite journal | author=Izraeli S, Colaizzo-Anas T, Bertness VL, "et al." |title=Expression of the SIL gene is correlated with growth induction and cellular proliferation. |journal=Cell Growth Differ. |volume=8 |issue= 11 |pages= 1171–9 |year= 1997 |pmid= 9372240 |doi=
*cite journal | author=Göttgens B, Barton LM, Gilbert JG, "et al." |title=Analysis of vertebrate SCL loci identifies conserved enhancers. |journal=Nat. Biotechnol. |volume=18 |issue= 2 |pages= 181–6 |year= 2000 |pmid= 10657125 |doi= 10.1038/72635
*cite journal | author=Raghavan SC, Kirsch IR, Lieber MR |title=Analysis of the V(D)J recombination efficiency at lymphoid chromosomal translocation breakpoints. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 29126–33 |year= 2001 |pmid= 11390401 |doi= 10.1074/jbc.M103797200
*cite journal | author=Carlotti E, Pettenella F, Amaru R, "et al." |title=Molecular characterization of a new recombination of the SIL/TAL-1 locus in a child with T-cell acute lymphoblastic leukaemia. |journal=Br. J. Haematol. |volume=118 |issue= 4 |pages= 1011–8 |year= 2002 |pmid= 12199779 |doi=
*cite journal | author=Karkera JD, Izraeli S, Roessler E, "et al." |title=The genomic structure, chromosomal localization, and analysis of SIL as a candidate gene for holoprosencephaly. |journal=Cytogenet. Genome Res. |volume=97 |issue= 1-2 |pages= 62–7 |year= 2003 |pmid= 12438740 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Colaizzo-Anas T, Aplan PD |title=Cloning and characterization of the SIL promoter. |journal=Biochim. Biophys. Acta |volume=1625 |issue= 2 |pages= 207–13 |year= 2003 |pmid= 12531481 |doi=
*cite journal | author=Curry JD, Smith MT |title=Measurement of SIL-TAL1 fusion gene transcripts associated with human T-cell lymphocytic leukemia by real-time reverse transcriptase-PCR. |journal=Leuk. Res. |volume=27 |issue= 7 |pages= 575–82 |year= 2003 |pmid= 12681356 |doi=
*cite journal | author=Cavé H, Suciu S, Preudhomme C, "et al." |title=Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951. |journal=Blood |volume=103 |issue= 2 |pages= 442–50 |year= 2004 |pmid= 14504110 |doi= 10.1182/blood-2003-05-1495
*cite journal | author=Erez A, Perelman M, Hewitt SM, "et al." |title=Sil overexpression in lung cancer characterizes tumors with increased mitotic activity. |journal=Oncogene |volume=23 |issue= 31 |pages= 5371–7 |year= 2004 |pmid= 15107824 |doi= 10.1038/sj.onc.1207685
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Campaner S, Kaldis P, Izraeli S, Kirsch IR |title=Sil phosphorylation in a Pin1 binding domain affects the duration of the spindle checkpoint. |journal=Mol. Cell. Biol. |volume=25 |issue= 15 |pages= 6660–72 |year= 2005 |pmid= 16024801 |doi= 10.1128/MCB.25.15.6660-6672.2005
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406

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