RPLP2

Ribosomal protein, large, P2, also known as RPLP2, is a human gene.cite web | title = Entrez Gene: RPLP2 ribosomal protein, large, P2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6181| accessdate = ]

PBB_Summary
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summary_text = Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P1. The P2 protein can interact with P0 and P1 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.cite web | title = Entrez Gene: RPLP2 ribosomal protein, large, P2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6181| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wool IG, Chan YL, Glück A |title=Structure and evolution of mammalian ribosomal proteins. |journal=Biochem. Cell Biol. |volume=73 |issue= 11-12 |pages= 933–47 |year= 1996 |pmid= 8722009 |doi=
*cite journal | author=Hochstrasser DF, Frutiger S, Paquet N, "et al." |title=Human liver protein
journal=Electrophoresis |volume=13 |issue= 12 |pages= 992–1001 |year= 1993 |pmid= 1286669 |doi=
*cite journal | author=Sharp MG, Adams SM, Elvin P, "et al." |title=A sequence previously identified as metastasis-related encodes an acidic ribosomal phosphoprotein, P2. |journal=Br. J. Cancer |volume=61 |issue= 1 |pages= 83–8 |year= 1990 |pmid= 2153399 |doi=
*cite journal | author=Rich BE, Steitz JA |title=Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly. |journal=Mol. Cell. Biol. |volume=7 |issue= 11 |pages= 4065–74 |year= 1988 |pmid= 3323886 |doi=
*cite journal | author=Kato S, Sekine S, Oh SW, "et al." |title=Construction of a human full-length cDNA bank. |journal=Gene |volume=150 |issue= 2 |pages= 243–50 |year= 1995 |pmid= 7821789 |doi=
*cite journal | author=Matoba R, Okubo K, Hori N, "et al." |title=The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression. |journal=Gene |volume=146 |issue= 2 |pages= 199–207 |year= 1994 |pmid= 8076819 |doi=
*cite journal | author=Scanlan MJ, Gordan JD, Williamson B, "et al." |title=Antigens recognized by autologous antibody in patients with renal-cell carcinoma. |journal=Int. J. Cancer |volume=83 |issue= 4 |pages= 456–64 |year= 1999 |pmid= 10508479 |doi=
*cite journal | author=Tchórzewski M, Boldyreff B, Issinger O, Grankowski N |title=Analysis of the protein-protein interactions between the human acidic ribosomal P-proteins: evaluation by the two hybrid system. |journal=Int. J. Biochem. Cell Biol. |volume=32 |issue= 7 |pages= 737–46 |year= |pmid= 10856704 |doi=
*cite journal | author=Uechi T, Tanaka T, Kenmochi N |title=A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders. |journal=Genomics |volume=72 |issue= 3 |pages= 223–30 |year= 2001 |pmid= 11401437 |doi= 10.1006/geno.2000.6470
*cite journal | author=Yoshihama M, Uechi T, Asakawa S, "et al." |title=The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. |journal=Genome Res. |volume=12 |issue= 3 |pages= 379–90 |year= 2002 |pmid= 11875025 |doi= 10.1101/gr.214202
*cite journal | author=Freeman JL, Gonzalo P, Pitcher JA, "et al." |title=Beta 2-adrenergic receptor stimulated, G protein-coupled receptor kinase 2 mediated, phosphorylation of ribosomal protein P2. |journal=Biochemistry |volume=41 |issue= 42 |pages= 12850–7 |year= 2002 |pmid= 12379128 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Tchórzewski M, Krokowski D, Rzeski W, "et al." |title=The subcellular distribution of the human ribosomal "stalk" components: P1, P2 and P0 proteins. |journal=Int. J. Biochem. Cell Biol. |volume=35 |issue= 2 |pages= 203–11 |year= 2003 |pmid= 12479870 |doi=
*cite journal | author=Shu H, Chen S, Bi Q, "et al." |title=Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line. |journal=Mol. Cell Proteomics |volume=3 |issue= 3 |pages= 279–86 |year= 2004 |pmid= 14729942 |doi= 10.1074/mcp.D300003-MCP200
*cite journal | author=Gardner-Thorpe J, Ito H, Ashley SW, Whang EE |title=Ribosomal protein P2: a potential molecular target for antisense therapy of human malignancies. |journal=Anticancer Res. |volume=23 |issue= 6C |pages= 4549–60 |year= 2004 |pmid= 14981896 |doi=
*cite journal | author=Giorgianni F, Beranova-Giorgianni S, Desiderio DM |title=Identification and characterization of phosphorylated proteins in the human pituitary. |journal=Proteomics |volume=4 |issue= 3 |pages= 587–98 |year= 2004 |pmid= 14997482 |doi= 10.1002/pmic.200300584
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Andersen JS, Lam YW, Leung AK, "et al." |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207

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