HBZ

HBZ

Hemoglobin, zeta, also known as HBZ, is a human gene.cite web | title = Entrez Gene: HBZ hemoglobin, zeta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3050| accessdate = ]

PBB_Summary
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summary_text = Zeta-globin is an alpha-like hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult like. The zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 -alpha-1 - theta1 - 3'.cite web | title = Entrez Gene: HBZ hemoglobin, zeta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3050| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Higgs DR, Vickers MA, Wilkie AO, "et al." |title=A review of the molecular genetics of the human alpha-globin gene cluster. |journal=Blood |volume=73 |issue= 5 |pages= 1081–104 |year= 1989 |pmid= 2649166 |doi=
*cite journal | author=Giardina B, Messana I, Scatena R, Castagnola M |title=The multiple functions of hemoglobin. |journal=Crit. Rev. Biochem. Mol. Biol. |volume=30 |issue= 3 |pages= 165–96 |year= 1995 |pmid= 7555018 |doi=
*cite journal | author=Proudfoot NJ, Brownlee GG |title=3' non-coding region sequences in eukaryotic messenger RNA. |journal=Nature |volume=263 |issue= 5574 |pages= 211–4 |year= 1976 |pmid= 822353 |doi=
*cite journal | author=Fougerousse F, Meloni R, Roudaut C, Beckmann JS |title=Dinucleotide repeat polymorphism at the human hemoglobin alpha-1 pseudo-gene (HBAP1). |journal=Nucleic Acids Res. |volume=20 |issue= 5 |pages= 1165 |year= 1992 |pmid= 1549498 |doi=
*cite journal | author=Hess J, Perez-Stable C, Wu GJ, "et al." |title=End-to-end transcription of an Alu family repeat. A new type of polymerase-III-dependent terminator and its evolutionary implication. |journal=J. Mol. Biol. |volume=184 |issue= 1 |pages= 7–21 |year= 1985 |pmid= 2411938 |doi=
*cite journal | author=Marotta CA, Forget BG, Weissman SM, "et al." |title=Nucleotide sequences of human globin messenger RNA. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=71 |issue= 6 |pages= 2300–4 |year= 1974 |pmid= 4135409 |doi=
*cite journal | author=Perez-Stable C, Ayres TM, Shen CK |title=Distinctive sequence organization and functional programming of an Alu repeat promoter. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=81 |issue= 17 |pages= 5291–5 |year= 1984 |pmid= 6089189 |doi=
*cite journal | author=Clegg JB, Gagnon J |title=Structure of the zeta chain of human embryonic hemoglobin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=78 |issue= 10 |pages= 6076–80 |year= 1982 |pmid= 6171809 |doi=
*cite journal | author=Aschauer H, Schäfer W, Sanguansermsri T, Braunitzer G |title= [Human embryonic haemoglobins. Ac-Ser-Leu-Thr-is the N-terminal sequence of the zeta-chains (author's transl)] |journal=Hoppe-Seyler's Z. Physiol. Chem. |volume=362 |issue= 12 |pages= 1657–9 |year= 1982 |pmid= 6172357 |doi=
*cite journal | author=Aschauer H, Sanguansermsri T, Braunitzer G |title= [Human embryonic haemoglobins. The primary structure of the zeta chains (author's transl)] |journal=Hoppe-Seyler's Z. Physiol. Chem. |volume=362 |issue= 8 |pages= 1159–62 |year= 1982 |pmid= 6179844 |doi=
*cite journal | author=Proudfoot NJ, Gil A, Maniatis T |title=The structure of the human zeta-globin gene and a closely linked, nearly identical pseudogene. |journal=Cell |volume=31 |issue= 3 Pt 2 |pages= 553–63 |year= 1983 |pmid= 6297773 |doi=
*cite journal | author=Goodbourn SE, Higgs DR, Clegg JB, Weatherall DJ |title=Molecular basis of length polymorphism in the human zeta-globin gene complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=80 |issue= 16 |pages= 5022–6 |year= 1983 |pmid= 6308667 |doi=
*cite journal | author=Cohen-Solal MM, Authier B, deRiel JK, "et al." |title=Cloning and nucleotide sequence analysis of human embryonic zeta-globin cDNA. |journal=DNA |volume=1 |issue= 4 |pages= 355–63 |year= 1983 |pmid= 6963223 |doi=
*cite journal | author=Orkin SH, Michelson A |title=Partial deletion of the alpha-globin structural gene in human alpha-thalassaemia. |journal=Nature |volume=286 |issue= 5772 |pages= 538–40 |year= 1980 |pmid= 7402334 |doi=
*cite journal | author=Flint J, Thomas K, Micklem G, "et al." |title=The relationship between chromosome structure and function at a human telomeric region. |journal=Nat. Genet. |volume=15 |issue= 3 |pages= 252–7 |year= 1997 |pmid= 9054936 |doi= 10.1038/ng0397-252
*cite journal | author=Luo HY, Liang XL, Frye C, "et al." |title=Embryonic hemoglobins are expressed in definitive cells. |journal=Blood |volume=94 |issue= 1 |pages= 359–61 |year= 1999 |pmid= 10381533 |doi=
*cite journal | author=Daniels RJ, Peden JF, Lloyd C, "et al." |title=Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. |journal=Hum. Mol. Genet. |volume=10 |issue= 4 |pages= 339–52 |year= 2001 |pmid= 11157797 |doi=
*cite journal | author=Lau ET, Kwok YK, Chui DH, "et al." |title=Embryonic and fetal globins are expressed in adult erythroid progenitor cells and in erythroid cell cultures. |journal=Prenat. Diagn. |volume=21 |issue= 7 |pages= 529–39 |year= 2001 |pmid= 11494285 |doi= 10.1002/pd.81

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