BRF1 (gene)

BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae), also known as BRF1, is a human gene.cite web | title = Entrez Gene: BRF1 BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2972| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Three alternatively spliced variants encoding three different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified. A transcript encoding a fourth isoform has not yet been completely characterized.cite web | title = Entrez Gene: BRF1 BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2972| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wang Z, Roeder RG |title=Structure and function of a human transcription factor TFIIIB subunit that is evolutionarily conserved and contains both TFIIB- and high-mobility-group protein 2-related domains. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 15 |pages= 7026–30 |year= 1995 |pmid= 7624363 |doi=
*cite journal | author=Mital R, Kobayashi R, Hernandez N |title=RNA polymerase III transcription from the human U6 and adenovirus type 2 VAI promoters has different requirements for human BRF, a subunit of human TFIIIB. |journal=Mol. Cell. Biol. |volume=16 |issue= 12 |pages= 7031–42 |year= 1997 |pmid= 8943358 |doi=
*cite journal | author=Chesnokov I, Chu WM, Botchan MR, Schmid CW |title=p53 inhibits RNA polymerase III-directed transcription in a promoter-dependent manner. |journal=Mol. Cell. Biol. |volume=16 |issue= 12 |pages= 7084–8 |year= 1997 |pmid= 8943363 |doi=
*cite journal | author=Chu WM, Wang Z, Roeder RG, Schmid CW |title=RNA polymerase III transcription repressed by Rb through its interactions with TFIIIB and TFIIIC2. |journal=J. Biol. Chem. |volume=272 |issue= 23 |pages= 14755–61 |year= 1997 |pmid= 9169441 |doi=
*cite journal | author=Wang Z, Roeder RG |title=Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation. |journal=Genes Dev. |volume=11 |issue= 10 |pages= 1315–26 |year= 1997 |pmid= 9171375 |doi=
*cite journal | author=Sutcliffe JE, Cairns CA, McLees A, "et al." |title=RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130. |journal=Mol. Cell. Biol. |volume=19 |issue= 6 |pages= 4255–61 |year= 1999 |pmid= 10330166 |doi=
*cite journal | author=Hsieh YJ, Wang Z, Kovelman R, Roeder RG |title=Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III. |journal=Mol. Cell. Biol. |volume=19 |issue= 7 |pages= 4944–52 |year= 1999 |pmid= 10373544 |doi=
*cite journal | author=Hsieh YJ, Kundu TK, Wang Z, "et al." |title=The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity. |journal=Mol. Cell. Biol. |volume=19 |issue= 11 |pages= 7697–704 |year= 1999 |pmid= 10523658 |doi=
*cite journal | author=McCulloch V, Hardin P, Peng W, "et al." |title=Alternatively spliced hBRF variants function at different RNA polymerase III promoters. |journal=EMBO J. |volume=19 |issue= 15 |pages= 4134–43 |year= 2000 |pmid= 10921893 |doi= 10.1093/emboj/19.15.4134
*cite journal | author=Johnston IM, Allison SJ, Morton JP, "et al." |title=CK2 forms a stable complex with TFIIIB and activates RNA polymerase III transcription in human cells. |journal=Mol. Cell. Biol. |volume=22 |issue= 11 |pages= 3757–68 |year= 2002 |pmid= 11997511 |doi=
*cite journal | author=Cabart P, Murphy S |title=Assembly of human small nuclear RNA gene-specific transcription factor IIIB complex de novo on and off promoter. |journal=J. Biol. Chem. |volume=277 |issue= 30 |pages= 26831–8 |year= 2002 |pmid= 12016223 |doi= 10.1074/jbc.M203119200
*cite journal | author=Willis IM |title=A universal nomenclature for subunits of the RNA polymerase III transcription initiation factor TFIIIB. |journal=Genes Dev. |volume=16 |issue= 11 |pages= 1337–8 |year= 2002 |pmid= 12066800 |doi=
*cite journal | author=Stoecklin G, Colombi M, Raineri I, "et al." |title=Functional cloning of BRF1, a regulator of ARE-dependent mRNA turnover. |journal=EMBO J. |volume=21 |issue= 17 |pages= 4709–18 |year= 2002 |pmid= 12198173 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Weser S, Riemann J, Seifart KH, Meissner W |title=Assembly and isolation of intermediate steps of transcription complexes formed on the human 5S rRNA gene. |journal=Nucleic Acids Res. |volume=31 |issue= 9 |pages= 2408–16 |year= 2003 |pmid= 12711686 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Schmidlin M, Lu M, Leuenberger SA, "et al." |title=The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B. |journal=EMBO J. |volume=23 |issue= 24 |pages= 4760–9 |year= 2005 |pmid= 15538381 |doi= 10.1038/sj.emboj.7600477
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Lim J, Hao T, Shaw C, "et al." |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes