JAM3

Junctional adhesion molecule 3, also known as JAM3, is a human gene.cite web | title = Entrez Gene: JAM3 junctional adhesion molecule 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83700| accessdate = ]

PBB_Summary
section_title =
summary_text = Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family.cite web | title = Entrez Gene: JAM3 junctional adhesion molecule 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83700| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Muller WA |title=Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response. |journal=Trends Immunol. |volume=24 |issue= 6 |pages= 327–34 |year= 2003 |pmid= 12810109 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Arrate MP, Rodriguez JM, Tran TM, "et al." |title=Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptor. |journal=J. Biol. Chem. |volume=276 |issue= 49 |pages= 45826–32 |year= 2002 |pmid= 11590146 |doi= 10.1074/jbc.M105972200
*cite journal | author=Aurrand-Lions M, Johnson-Leger C, Wong C, "et al." |title=Heterogeneity of endothelial junctions is reflected by differential expression and specific subcellular localization of the three JAM family members. |journal=Blood |volume=98 |issue= 13 |pages= 3699–707 |year= 2002 |pmid= 11739175 |doi=
*cite journal | author=Liang TW, Chiu HH, Gurney A, "et al." |title=Vascular endothelial-junctional adhesion molecule (VE-JAM)/JAM 2 interacts with T, NK, and dendritic cells through JAM 3. |journal=J. Immunol. |volume=168 |issue= 4 |pages= 1618–26 |year= 2002 |pmid= 11823489 |doi=
*cite journal | author=Phillips HM, Renforth GL, Spalluto C, "et al." |title=Narrowing the critical region within 11q24-qter for hypoplastic left heart and identification of a candidate gene, JAM3, expressed during cardiogenesis. |journal=Genomics |volume=79 |issue= 4 |pages= 475–8 |year= 2002 |pmid= 11944976 |doi= 10.1006/geno.2002.6742
*cite journal | author=Cunningham SA, Rodriguez JM, Arrate MP, "et al." |title=JAM2 interacts with alpha4beta1. Facilitation by JAM3. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 27589–92 |year= 2002 |pmid= 12070135 |doi= 10.1074/jbc.C200331200
*cite journal | author=Santoso S, Sachs UJ, Kroll H, "et al." |title=The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1. |journal=J. Exp. Med. |volume=196 |issue= 5 |pages= 679–91 |year= 2002 |pmid= 12208882 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ebnet K, Aurrand-Lions M, Kuhn A, "et al." |title=The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity. |journal=J. Cell. Sci. |volume=116 |issue= Pt 19 |pages= 3879–91 |year= 2004 |pmid= 12953056 |doi= 10.1242/jcs.00704
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Zen K, Babbin BA, Liu Y, "et al." |title=JAM-C is a component of desmosomes and a ligand for CD11b/CD18-mediated neutrophil transepithelial migration. |journal=Mol. Biol. Cell |volume=15 |issue= 8 |pages= 3926–37 |year= 2005 |pmid= 15194813 |doi= 10.1091/mbc.E04-04-0317
*cite journal | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504
*cite journal | author=Chavakis T, Keiper T, Matz-Westphal R, "et al." |title=The junctional adhesion molecule-C promotes neutrophil transendothelial migration in vitro and in vivo. |journal=J. Biol. Chem. |volume=279 |issue= 53 |pages= 55602–8 |year= 2005 |pmid= 15485832 |doi= 10.1074/jbc.M404676200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Aurrand-Lions M, Lamagna C, Dangerfield JP, "et al." |title=Junctional adhesion molecule-C regulates the early influx of leukocytes into tissues during inflammation. |journal=J. Immunol. |volume=174 |issue= 10 |pages= 6406–15 |year= 2005 |pmid= 15879142 |doi=
*cite journal | author=Santoso S, Orlova VV, Song K, "et al." |title=The homophilic binding of junctional adhesion molecule-C mediates tumor cell-endothelial cell interactions. |journal=J. Biol. Chem. |volume=280 |issue= 43 |pages= 36326–33 |year= 2006 |pmid= 16118203 |doi= 10.1074/jbc.M505059200

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