MED24

Thyroid hormone receptor associated protein 4, also known as THRAP4, is a human gene.cite web | title = Entrez Gene: THRAP4 thyroid hormone receptor associated protein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9862| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: THRAP4 thyroid hormone receptor associated protein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9862| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gustafsson CM, Samuelsson T |title=Mediator--a universal complex in transcriptional regulation. |journal=Mol. Microbiol. |volume=41 |issue= 1 |pages= 1–8 |year= 2001 |pmid= 11454195 |doi=
*cite journal | author=Malik S, Roeder RG |title=Dynamic regulation of pol II transcription by the mammalian Mediator complex. |journal=Trends Biochem. Sci. |volume=30 |issue= 5 |pages= 256–63 |year= 2005 |pmid= 15896744 |doi= 10.1016/j.tibs.2005.03.009
*cite journal | author=Nagase T, Seki N, Tanaka A, "et al." |title=Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=2 |issue= 4 |pages= 167–74, 199–210 |year= 1996 |pmid= 8590280 |doi=
*cite journal | author=Fondell JD, Ge H, Roeder RG |title=Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 16 |pages= 8329–33 |year= 1996 |pmid= 8710870 |doi=
*cite journal | author=Rachez C, Suldan Z, Ward J, "et al." |title=A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system. |journal=Genes Dev. |volume=12 |issue= 12 |pages= 1787–800 |year= 1998 |pmid= 9637681 |doi=
*cite journal | author=Yuan CX, Ito M, Fondell JD, "et al." |title=The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 14 |pages= 7939–44 |year= 1998 |pmid= 9653119 |doi=
*cite journal | author=Gu W, Malik S, Ito M, "et al." |title=A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. |journal=Mol. Cell |volume=3 |issue= 1 |pages= 97–108 |year= 1999 |pmid= 10024883 |doi=
*cite journal | author=Ito M, Yuan CX, Malik S, "et al." |title=Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. |journal=Mol. Cell |volume=3 |issue= 3 |pages= 361–70 |year= 1999 |pmid= 10198638 |doi=
*cite journal | author=Rachez C, Lemon BD, Suldan Z, "et al." |title=Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. |journal=Nature |volume=398 |issue= 6730 |pages= 824–8 |year= 1999 |pmid= 10235266 |doi= 10.1038/19783
*cite journal | author=Näär AM, Beaurang PA, Zhou S, "et al." |title=Composite co-activator ARC mediates chromatin-directed transcriptional activation. |journal=Nature |volume=398 |issue= 6730 |pages= 828–32 |year= 1999 |pmid= 10235267 |doi= 10.1038/19789
*cite journal | author=Ryu S, Tjian R |title=Purification of transcription cofactor complex CRSP. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 13 |pages= 7137–42 |year= 1999 |pmid= 10377381 |doi=
*cite journal | author=Zhang J, Fondell JD |title=Identification of mouse TRAP100: a transcriptional coregulatory factor for thyroid hormone and vitamin D receptors. |journal=Mol. Endocrinol. |volume=13 |issue= 7 |pages= 1130–40 |year= 1999 |pmid= 10406464 |doi=
*cite journal | author=Taatjes DJ, Näär AM, Andel F, "et al." |title=Structure, function, and activator-induced conformations of the CRSP coactivator. |journal=Science |volume=295 |issue= 5557 |pages= 1058–62 |year= 2002 |pmid= 11834832 |doi= 10.1126/science.1065249
*cite journal | author=Surapureddi S, Yu S, Bu H, "et al." |title=Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 18 |pages= 11836–41 |year= 2002 |pmid= 12189208 |doi= 10.1073/pnas.182426699
*cite journal | author=Wang Q, Sharma D, Ren Y, Fondell JD |title=A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 42852–8 |year= 2003 |pmid= 12218053 |doi= 10.1074/jbc.M206061200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Sato S, Tomomori-Sato C, Banks CA, "et al." |title=A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex. |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 49671–4 |year= 2004 |pmid= 14576168 |doi= 10.1074/jbc.C300444200
*cite journal | author=Tomomori-Sato C, Sato S, Parmely TJ, "et al." |title=A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5846–51 |year= 2004 |pmid= 14638676 |doi= 10.1074/jbc.M312523200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285

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