ECT2

ECT2

Epithelial cell transforming sequence 2 oncogene, also known as ECT2, is a human gene.cite web | title = Entrez Gene: ECT2 epithelial cell transforming sequence 2 oncogene| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1894| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis.cite web | title = Entrez Gene: ECT2 epithelial cell transforming sequence 2 oncogene| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1894| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Takai S, Long JE, Yamada K, Miki T |title=Chromosomal localization of the human ECT2 proto-oncogene to 3q26.1-->q26.2 by somatic cell analysis and fluorescence in situ hybridization. |journal=Genomics |volume=27 |issue= 1 |pages= 220–2 |year= 1995 |pmid= 7665179 |doi= 10.1006/geno.1995.1033
*cite journal | author=Miki T, Smith CL, Long JE, "et al." |title=Oncogene ect2 is related to regulators of small GTP-binding proteins. |journal=Nature |volume=362 |issue= 6419 |pages= 462–5 |year= 1993 |pmid= 8464478 |doi= 10.1038/362462a0
*cite journal | author=Hillier LD, Lennon G, Becker M, "et al." |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=
*cite journal | author=Tatsumoto T, Xie X, Blumenthal R, "et al." |title=Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis. |journal=J. Cell Biol. |volume=147 |issue= 5 |pages= 921–8 |year= 1999 |pmid= 10579713 |doi=
*cite journal | author=Kimura K, Tsuji T, Takada Y, "et al." |title=Accumulation of GTP-bound RhoA during cytokinesis and a critical role of ECT2 in this accumulation. |journal=J. Biol. Chem. |volume=275 |issue= 23 |pages= 17233–6 |year= 2000 |pmid= 10837491 |doi= 10.1074/jbc.C000212200
*cite journal | author=Wennerberg K, Ellerbroek SM, Liu RY, "et al." |title=RhoG signals in parallel with Rac1 and Cdc42. |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47810–7 |year= 2003 |pmid= 12376551 |doi= 10.1074/jbc.M203816200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Matsuda A, Suzuki Y, Honda G, "et al." |title=Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. |journal=Oncogene |volume=22 |issue= 21 |pages= 3307–18 |year= 2003 |pmid= 12761501 |doi= 10.1038/sj.onc.1206406
*cite journal | author=Saito S, Tatsumoto T, Lorenzi MV, "et al." |title=Rho exchange factor ECT2 is induced by growth factors and regulates cytokinesis through the N-terminal cell cycle regulator-related domains. |journal=J. Cell. Biochem. |volume=90 |issue= 4 |pages= 819–36 |year= 2004 |pmid= 14587037 |doi= 10.1002/jcb.10688
*cite journal | author=Hara T, Ishida H, Raziuddin R, "et al." |title=Novel kelch-like protein, KLEIP, is involved in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. |journal=Mol. Biol. Cell |volume=15 |issue= 3 |pages= 1172–84 |year= 2004 |pmid= 14668487 |doi= 10.1091/mbc.E03-07-0531
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Liu XF, Ishida H, Raziuddin R, Miki T |title=Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity. |journal=Mol. Cell. Biol. |volume=24 |issue= 15 |pages= 6665–75 |year= 2004 |pmid= 15254234 |doi= 10.1128/MCB.24.15.6665-6675.2004
*cite journal | author=Kim JE, Billadeau DD, Chen J |title=The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis. |journal=J. Biol. Chem. |volume=280 |issue= 7 |pages= 5733–9 |year= 2005 |pmid= 15545273 |doi= 10.1074/jbc.M409298200
*cite journal | author=Oceguera-Yanez F, Kimura K, Yasuda S, "et al." |title=Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis. |journal=J. Cell Biol. |volume=168 |issue= 2 |pages= 221–32 |year= 2005 |pmid= 15642749 |doi= 10.1083/jcb.200408085
*cite journal | author=Yüce O, Piekny A, Glotzer M |title=An ECT2-centralspindlin complex regulates the localization and function of RhoA. |journal=J. Cell Biol. |volume=170 |issue= 4 |pages= 571–82 |year= 2007 |pmid= 16103226 |doi= 10.1083/jcb.200501097
*cite journal | author=Niiya F, Xie X, Lee KS, "et al." |title=Inhibition of cyclin-dependent kinase 1 induces cytokinesis without chromosome segregation in an ECT2 and MgcRacGAP-dependent manner. |journal=J. Biol. Chem. |volume=280 |issue= 43 |pages= 36502–9 |year= 2006 |pmid= 16118207 |doi= 10.1074/jbc.M508007200
*cite journal | author=Zhao WM, Fang G |title=MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 37 |pages= 13158–63 |year= 2005 |pmid= 16129829 |doi= 10.1073/pnas.0504145102
*cite journal | author=Hara T, Abe M, Inoue H, "et al." |title=Cytokinesis regulator ECT2 changes its conformation through phosphorylation at Thr-341 in G2/M phase. |journal=Oncogene |volume=25 |issue= 4 |pages= 566–78 |year= 2006 |pmid= 16170345 |doi= 10.1038/sj.onc.1209078
*cite journal | author=Niiya F, Tatsumoto T, Lee KS, Miki T |title=Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA. |journal=Oncogene |volume=25 |issue= 6 |pages= 827–37 |year= 2006 |pmid= 16247472 |doi= 10.1038/sj.onc.1209124
*cite journal | author=Nishimura Y, Yonemura S |title=Centralspindlin regulates ECT2 and RhoA accumulation at the equatorial cortex during cytokinesis. |journal=J. Cell. Sci. |volume=119 |issue= Pt 1 |pages= 104–14 |year= 2006 |pmid= 16352658 |doi= 10.1242/jcs.02737

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Нужно сделать НИР?

Look at other dictionaries:

  • PARD6A — Par 6 partitioning defective 6 homolog alpha (C. elegans) PDB rendering based on 1wmh …   Wikipedia

  • RhoG — (Ras homology Growth related) (or ARGH) is a small ( 21 kDa) monomeric GTP binding protein (G protein), and is an important component of many intracellular signalling pathways. It is a member of the Rac subfamily of the Rho family of small G… …   Wikipedia

  • Cytokinesis — A cell that has almost completed cytokinesis. An arrow points to a centrosome that can still be seen …   Wikipedia

  • Keratin 4 — Identifiers Symbols KRT4; CK 4; CK4; CYK4; FLJ31692; K4 External IDs OMIM …   Wikipedia

  • RhoGEF domain — Structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein.[1] Identifiers Symbol …   Wikipedia

  • PARD3 — Par 3 partitioning defective 3 homolog (C. elegans) Identifiers Symbols PARD3; ASIP; Baz; Bazooka; FLJ21015; PAR3; PAR3alpha; PARD3A; SE2 5L16; SE2 5LT1; SE2 5T2 External IDs …   Wikipedia

  • Citocinesis — esquema de citocinesis …   Wikipedia Español

  • Dbl family — (= Dbl, Dbs, Brx, Lfc, Lsc, Ect2, DRhoGEF2, Vav) Family of proteins containing DH domains and with guanine nucleotide exchange factor activity for rho family of small G proteins …   Dictionary of molecular biology

  • DH domain — (= Dbl homology domain) Domain of around 250 amino acids found in Dbl, Vav and a family of other Dbl family proteins (Lfc, Lsc, Ect2, Dbs, Brx). DH domains are invariably located immediately N terminal to PH domain and the membrane localization… …   Dictionary of molecular biology

  • sos — Guanine nucleotide releasing factor (155kD), the mammalian homologue of son of sevenless. The proline rich region of sos binds to the SH3 domain of GRB2. Has homology with CDC 25, the yeast GTP releasing factor for ras. A family of related… …   Dictionary of molecular biology

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”