ECT2

ECT2

Epithelial cell transforming sequence 2 oncogene, also known as ECT2, is a human gene.cite web | title = Entrez Gene: ECT2 epithelial cell transforming sequence 2 oncogene| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1894| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis.cite web | title = Entrez Gene: ECT2 epithelial cell transforming sequence 2 oncogene| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1894| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Takai S, Long JE, Yamada K, Miki T |title=Chromosomal localization of the human ECT2 proto-oncogene to 3q26.1-->q26.2 by somatic cell analysis and fluorescence in situ hybridization. |journal=Genomics |volume=27 |issue= 1 |pages= 220–2 |year= 1995 |pmid= 7665179 |doi= 10.1006/geno.1995.1033
*cite journal | author=Miki T, Smith CL, Long JE, "et al." |title=Oncogene ect2 is related to regulators of small GTP-binding proteins. |journal=Nature |volume=362 |issue= 6419 |pages= 462–5 |year= 1993 |pmid= 8464478 |doi= 10.1038/362462a0
*cite journal | author=Hillier LD, Lennon G, Becker M, "et al." |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=
*cite journal | author=Tatsumoto T, Xie X, Blumenthal R, "et al." |title=Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis. |journal=J. Cell Biol. |volume=147 |issue= 5 |pages= 921–8 |year= 1999 |pmid= 10579713 |doi=
*cite journal | author=Kimura K, Tsuji T, Takada Y, "et al." |title=Accumulation of GTP-bound RhoA during cytokinesis and a critical role of ECT2 in this accumulation. |journal=J. Biol. Chem. |volume=275 |issue= 23 |pages= 17233–6 |year= 2000 |pmid= 10837491 |doi= 10.1074/jbc.C000212200
*cite journal | author=Wennerberg K, Ellerbroek SM, Liu RY, "et al." |title=RhoG signals in parallel with Rac1 and Cdc42. |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47810–7 |year= 2003 |pmid= 12376551 |doi= 10.1074/jbc.M203816200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Matsuda A, Suzuki Y, Honda G, "et al." |title=Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. |journal=Oncogene |volume=22 |issue= 21 |pages= 3307–18 |year= 2003 |pmid= 12761501 |doi= 10.1038/sj.onc.1206406
*cite journal | author=Saito S, Tatsumoto T, Lorenzi MV, "et al." |title=Rho exchange factor ECT2 is induced by growth factors and regulates cytokinesis through the N-terminal cell cycle regulator-related domains. |journal=J. Cell. Biochem. |volume=90 |issue= 4 |pages= 819–36 |year= 2004 |pmid= 14587037 |doi= 10.1002/jcb.10688
*cite journal | author=Hara T, Ishida H, Raziuddin R, "et al." |title=Novel kelch-like protein, KLEIP, is involved in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. |journal=Mol. Biol. Cell |volume=15 |issue= 3 |pages= 1172–84 |year= 2004 |pmid= 14668487 |doi= 10.1091/mbc.E03-07-0531
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Liu XF, Ishida H, Raziuddin R, Miki T |title=Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity. |journal=Mol. Cell. Biol. |volume=24 |issue= 15 |pages= 6665–75 |year= 2004 |pmid= 15254234 |doi= 10.1128/MCB.24.15.6665-6675.2004
*cite journal | author=Kim JE, Billadeau DD, Chen J |title=The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis. |journal=J. Biol. Chem. |volume=280 |issue= 7 |pages= 5733–9 |year= 2005 |pmid= 15545273 |doi= 10.1074/jbc.M409298200
*cite journal | author=Oceguera-Yanez F, Kimura K, Yasuda S, "et al." |title=Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis. |journal=J. Cell Biol. |volume=168 |issue= 2 |pages= 221–32 |year= 2005 |pmid= 15642749 |doi= 10.1083/jcb.200408085
*cite journal | author=Yüce O, Piekny A, Glotzer M |title=An ECT2-centralspindlin complex regulates the localization and function of RhoA. |journal=J. Cell Biol. |volume=170 |issue= 4 |pages= 571–82 |year= 2007 |pmid= 16103226 |doi= 10.1083/jcb.200501097
*cite journal | author=Niiya F, Xie X, Lee KS, "et al." |title=Inhibition of cyclin-dependent kinase 1 induces cytokinesis without chromosome segregation in an ECT2 and MgcRacGAP-dependent manner. |journal=J. Biol. Chem. |volume=280 |issue= 43 |pages= 36502–9 |year= 2006 |pmid= 16118207 |doi= 10.1074/jbc.M508007200
*cite journal | author=Zhao WM, Fang G |title=MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 37 |pages= 13158–63 |year= 2005 |pmid= 16129829 |doi= 10.1073/pnas.0504145102
*cite journal | author=Hara T, Abe M, Inoue H, "et al." |title=Cytokinesis regulator ECT2 changes its conformation through phosphorylation at Thr-341 in G2/M phase. |journal=Oncogene |volume=25 |issue= 4 |pages= 566–78 |year= 2006 |pmid= 16170345 |doi= 10.1038/sj.onc.1209078
*cite journal | author=Niiya F, Tatsumoto T, Lee KS, Miki T |title=Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA. |journal=Oncogene |volume=25 |issue= 6 |pages= 827–37 |year= 2006 |pmid= 16247472 |doi= 10.1038/sj.onc.1209124
*cite journal | author=Nishimura Y, Yonemura S |title=Centralspindlin regulates ECT2 and RhoA accumulation at the equatorial cortex during cytokinesis. |journal=J. Cell. Sci. |volume=119 |issue= Pt 1 |pages= 104–14 |year= 2006 |pmid= 16352658 |doi= 10.1242/jcs.02737

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