RASSF5

Ras association (RalGDS/AF-6) domain family 5, also known as RASSF5, is a human gene.cite web | title = Entrez Gene: RASSF5 Ras association (RalGDS/AF-6) domain family 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83593| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: RASSF5 Ras association (RalGDS/AF-6) domain family 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83593| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Vavvas D, Li X, Avruch J, Zhang XF |title=Identification of Nore1 as a potential Ras effector. |journal=J. Biol. Chem. |volume=273 |issue= 10 |pages= 5439–42 |year= 1998 |pmid= 9488663 |doi=
*cite journal | author=Ortiz-Vega S, Khokhlatchev A, Nedwidek M, "et al." |title=The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1. |journal=Oncogene |volume=21 |issue= 9 |pages= 1381–90 |year= 2002 |pmid= 11857081 |doi= 10.1038/sj.onc.1205192
*cite journal | author=Khokhlatchev A, Rabizadeh S, Xavier R, "et al." |title=Identification of a novel Ras-regulated proapoptotic pathway. |journal=Curr. Biol. |volume=12 |issue= 4 |pages= 253–65 |year= 2002 |pmid= 11864565 |doi=
*cite journal | author=Tommasi S, Dammann R, Jin SG, "et al." |title=RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1. |journal=Oncogene |volume=21 |issue= 17 |pages= 2713–20 |year= 2002 |pmid= 11965544 |doi= 10.1038/sj.onc.1205365
*cite journal | author=Yao R, Wang Y, You M |title=Chromosome mapping and sequence variation of the murine Ras effector gene Nore1. |journal=Cytogenet. Cell Genet. |volume=95 |issue= 1-2 |pages= 126–8 |year= 2002 |pmid= 11978988 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Vos MD, Martinez A, Ellis CA, "et al." |title=The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung. |journal=J. Biol. Chem. |volume=278 |issue= 24 |pages= 21938–43 |year= 2003 |pmid= 12676952 |doi= 10.1074/jbc.M211019200
*cite journal | author=Katagiri K, Maeda A, Shimonaka M, Kinashi T |title=RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1. |journal=Nat. Immunol. |volume=4 |issue= 8 |pages= 741–8 |year= 2003 |pmid= 12845325 |doi= 10.1038/ni950
*cite journal | author=Chen J, Lui WO, Vos MD, "et al." |title=The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas. |journal=Cancer Cell |volume=4 |issue= 5 |pages= 405–13 |year= 2004 |pmid= 14667507 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Praskova M, Khoklatchev A, Ortiz-Vega S, Avruch J |title=Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras. |journal=Biochem. J. |volume=381 |issue= Pt 2 |pages= 453–62 |year= 2004 |pmid= 15109305 |doi= 10.1042/BJ20040025
*cite journal | author=Irimia M, Fraga MF, Sanchez-Cespedes M, Esteller M |title=CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer. |journal=Oncogene |volume=23 |issue= 53 |pages= 8695–9 |year= 2004 |pmid= 15378027 |doi= 10.1038/sj.onc.1207914
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Fujita H, Fukuhara S, Sakurai A, "et al." |title=Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes. |journal=J. Biol. Chem. |volume=280 |issue= 6 |pages= 5022–31 |year= 2005 |pmid= 15569673 |doi= 10.1074/jbc.M409701200
*cite journal | author=Nakamura N, Carney JA, Jin L, "et al." |title=RASSF1A and NORE1A methylation and BRAFV600E mutations in thyroid tumors. |journal=Lab. Invest. |volume=85 |issue= 9 |pages= 1065–75 |year= 2005 |pmid= 15980887 |doi= 10.1038/labinvest.3700306
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Foukakis T, Au AY, Wallin G, "et al." |title=The Ras effector NORE1A is suppressed in follicular thyroid carcinomas with a PAX8-PPARgamma fusion. |journal=J. Clin. Endocrinol. Metab. |volume=91 |issue= 3 |pages= 1143–9 |year= 2006 |pmid= 16352687 |doi= 10.1210/jc.2005-1372
*cite journal | author=Moshnikova A, Frye J, Shay JW, "et al." |title=The growth and tumor suppressor NORE1A is a cytoskeletal protein that suppresses growth by inhibition of the ERK pathway. |journal=J. Biol. Chem. |volume=281 |issue= 12 |pages= 8143–52 |year= 2006 |pmid= 16421102 |doi= 10.1074/jbc.M511837200
*cite journal | author=Macheiner D, Heller G, Kappel S, "et al." |title=NORE1B, a candidate tumor suppressor, is epigenetically silenced in human hepatocellular carcinoma. |journal=J. Hepatol. |volume=45 |issue= 1 |pages= 81–9 |year= 2006 |pmid= 16516329 |doi= 10.1016/j.jhep.2005.12.017
*cite journal | author=Ishiguro K, Avruch J, Landry A, "et al." |title=Nore1B regulates TCR signaling via Ras and Carma1. |journal=Cell. Signal. |volume=18 |issue= 10 |pages= 1647–54 |year= 2006 |pmid= 16520020 |doi= 10.1016/j.cellsig.2006.01.015

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